Results 91 to 100 of about 285,872 (230)

Granular flow down a rough inclined plane: transition between thin and thick piles

, 2002
The rheology of granular particles in an inclined plane geometry is studied using molecular dynamics simulations. The flow--no-flow boundary is determined for piles of varying heights over a range of inclination angles $\theta$.
Aguirre M. A., Aguirre M. A., Ahn H., Ancey C., Ancey C., Andreotti B., Aradian A., Aranson I. S., Bagnold R. A., Bocquet L., Cundall P. A., Daerr A., Daerr A., Ertaş D., Gary S. Grest, Hanes D. M., James W. Landry, Lemieux P.-A., Leonardo E. Silbert, Louge M. Y., Mehta A., Mills P., Nerone N., Pouliquen O., Pöschel T., Sadjadpour M., Silbert L. E., Silbert L. E., Silbert L. E., Silbert L. E., Silva M. D., Walton O. R., Zheng X. M., Zhou Y. C.   +33 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Transfer Length of Strands in Prestressed Concrete Piles [PDF]

, 2002
A top bar effect has been identified in prestressed concrete piles. The effect that this top bar effect has on the development of the prestressing strand is investigated. Strand transfer length is found to be proportional to the observed end slip.
Harries, Kent A., Petrou, Michael F., Wan, Baolin   +2 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Assessing the applicability of thermal response testing to energy piles

, 2014
Deep foundations are increasingly being used, not just to carry structural loads, but also to act as heat exchangers as part of a ground source heat pump system.
Brettmann, T., Loveridge, F.A., Olgun, C.G., Powrie, W.   +3 more
core  

Response of pile-guided floats subjected to dynamic loading [PDF]

, 2013
Pile-guided floats can be a desirable alternative to stationary berthing structures. Both floats and guide piles are subjected to time varying (dynamic) forces such as wind-generated waves and impacts from vessels.
Quan, Zhili, 权致力
core  

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source