Results 121 to 130 of about 39,152 (265)
Effect of Verapamil, Cinnarizine and Memantine on Maximal Electroshock, Picrotoxin, and Pilocarpine-Induced Seizure Models in Albino Mice [PDF]
, 2015 Ahmed A. Abdelsameea
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Astrocytic Igfbp2 Promotes Spontaneous Seizures in a Mouse Model of Mesial Temporal Lobe Epilepsy
Glia, Volume 74, Issue 1, January 2026.Igfbp2 is upregulated in hippocampal astrocytes of MTLE model mice. Igfbp2 enhances dentate granule cell excitability. Astrocytic Igfbp2 deletion reduces spontaneous seizures. ABSTRACT Mesial temporal lobe epilepsy (MTLE) is a common, frequently drug‐resistant epilepsy characterized by seizures arising from the hippocampus.
Shinichi Kinoshita +4 more
wiley +1 more source
Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy [PDF]
, 2022 Safwan K. Hyder +2 more
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Mass spectrometry in ocular drug research
Mass Spectrometry Reviews, Volume 45, Issue 1, Page 37-68, January/February 2026.Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo +6 more
wiley +1 more source
Vitreofoveal traction associated with the use of pilocarpine to reverse mydriasis [PDF]
, 2007 John D Walker, M M Alvarez
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Journal of Neurochemistry, Volume 170, Issue 1, January 2026.Approximately 30% of epilepsy patients do not respond to current medications. In addition, the pharmaceutical industry is reducing its interest in de novo drug discovery for epilepsy. Drug repurposing offers a promising alternative. This study investigated memantine, an Alzheimer's drug, in a zebrafish model of seizures.
Kamila Cagliari Zenki +9 more
wiley +1 more source
Journal of Oral Pathology &Medicine, Volume 55, Issue 1, Page 120-132, January 2026.ABSTRACT Background The antineoplastic drugs used in anticancer treatment regimens can induce changes in normal tissues, including salivary glands. This study evaluated the effects of clarified açaí and photobiomodulation (PBM) on the oxidative biochemistry and microstructure of the parotid glands of rats with oral mucositis. Methods Male rats (n = 54)
Wallacy Watson Pereira Melo +15 more
wiley +1 more source
PLoS ONEBackgroundIntractable xerostomia is defined as the subjective perception of dry mouth and persistent salivary gland hypofunction. Pilocarpine is an approved salivary sialagogue that is frequently prescribed for the treatment of intractable xerostomia ...
Su Il Kim +5 more
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Future Journal of Pharmaceutical SciencesBackground Pilocarpine HCl is a non-selective muscarinic receptor agonist that is prescribed for the treatment of glaucoma. The use of pilocarpine conventional eye drops is associated with several side effects, such as loss of visual acuity, and the need
Tamara Ahmad Alotaibi +3 more
doaj +1 more source