Results 21 to 30 of about 17,022 (157)

Aging and topical pilocarpine concentrations effects on pupil size and tear flow rate

Journal of Optometry, 2010
Purpose: This is to evaluate the effects of age and different concentrations of pilocarpine on tear flow rate and pupil size. Methods: The tear flow rates and pupil sizes of eighty-one volunteers were measured with Schimer's strips and a meter rule gauge,
Michael O. Emina
doaj   +1 more source

Administration of pilocarpine by microneedle patch as a novel method for cystic fibrosis sweat testing

Bioengineering & Translational Medicine, 2021
The sweat test is the gold standard for the diagnosis of cystic fibrosis (CF). The test utilizes iontophoresis to administer pilocarpine to the skin to induce sweating for measurement of chloride concentration in sweat.
Song Li, Kelsey Hart, Natalie Norton, Clare A. Ryan, Lokesh Guglani, Mark R. Prausnitz   +5 more
doaj   +1 more source

Excitatory synaptic transmission in hippocampal area CA1 is enhanced then reduced as chronic epilepsy progresses

Neurobiology of Disease, 2021
This study examines changes in synaptic transmission with progression of the chronic epileptic state. Male Sprague-Dawley rats (P40–45) were injected with either saline or pilocarpine.
Benjamin Owen, Edyta Bichler, Morris Benveniste   +2 more
doaj   +1 more source

Pilocarpine induces the residual secretion of salivary fluid in perfused submandibular glands of rats.

PLoS ONE, 2019
Pilocarpine is an M3 muscarinic agonist that is widely used for the treatment of xerostomia caused by various diseases and medical conditions. Pilocarpine induced the secretion of salivary fluid in perfused submandibular glands of rats.
Takanori Narita, Bing Qi, Masataka Murakami, Hiroshi Sugiya   +3 more
doaj   +1 more source

Effect of pilocarpine mouthwash on salivary flow

Brazilian Journal of Medical and Biological Research, 2002
Pilocarpine is a cholinergic agonist that increases salivary flow and has been used to treat xerostomia. Oral intake is the most frequent route of administration.
R. Bernardi, C. Perin, F.L. Becker, G.Z. Ramos, G.Z. Gheno, L.R. Lopes, M. Pires, H.M.T. Barros   +7 more
doaj   +1 more source

The effects of a varying doses of pilocarpine and lithium induced status epilepticus, and treatment with BPC-157

Liječnički vjesnik, 2023
Peptadecapeptide BPC -157 has been reported to have a large spectrum of in vivo activities, from anti-ulcer to central action on the brain dopaminergic system, in addition to the aforementioned, BPC-157 might counteract standard convulsant induced ...
Helen Marie Chiddenton, Sara Burić, Vlasta Vuković   +2 more
doaj   +1 more source

Antagonism of peripheral inflammation reduces the severity of status epilepticus

Neurobiology of Disease, 2009
Status epilepticus (SE) is one of the most serious manifestations of epilepsy. Systemic inflammation and damage of blood-brain barrier (BBB) are etiologic cofactors in the pathogenesis of pilocarpine SE while acute osmotic disruption of the BBB is ...
Nicola Marchi, Qingyuan Fan, Chaitali Ghosh, Vincent Fazio, Francesca Bertolini, Giulia Betto, Ayush Batra, Erin Carlton, Imad Najm, Tiziana Granata, Damir Janigro   +10 more
doaj   +1 more source

Pilocarpine-induced seizures associate with modifications of LSD1/CoREST/HDAC1/2 epigenetic complex and repressive chromatin in mice hippocampus

Biochemistry and Biophysics Reports, 2021
Epilepsy is a neurological disorder of genetic or environmental origin characterized by recurrent spontaneous seizures. A rodent model of temporal lobe epilepsy is induced by a single administration of pilocarpine, a non-selective cholinergic muscarinic ...
Verónica Noches, Carlos Rivera, Marcela P. González, Gianluca Merello, Montserrat Olivares-Costa, María Estela Andrés   +5 more
doaj   +1 more source

Sub-Convulsing Dose Administration of Pilocarpine Reduces Glycemia, Increases Anxiety-Like Behavior and Decelerates Cortical Spreading Depression in Rats Suckled on Various Litter Sizes

Frontiers in Neuroscience, 2018
Epilepsy and malnutrition constitute two worldwide health problems affecting behavior and brain function. The cholinergic agonist pilocarpine (300–380 mg/kg; single administration) reproduces the human type of temporal lobe epilepsy in rats.
Elian da Silva Francisco, Rubem Carlos Araújo Guedes   +1 more
doaj   +1 more source

Effect of eugenol on lithium-pilocarpine model of epilepsy: behavioral, histological, and molecular changes [PDF]

Iranian Journal of Basic Medical Sciences, 2017
Objective(s): Epilepsy establishment gives rise to biochemical and morphological changes in the hippocampus. Oxidative stress, morphological changes, and mossy fiber sprouting (MFS) in the hippocampus underpin the epilepsy establishment.
Sara Joushi, Mahmoud Elahdadi Salmani
doaj   +1 more source