Effect of oxidative stress on ABC transporters: contribution to epilepsy pharmacoresistance [PDF]
, 2017 Epilepsy is a neurological disorder affecting around 1%-2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression
Grewal, G. K. +5 more
core +2 more sources
Antagonism of peripheral inflammation reduces the severity of status epilepticus
Neurobiology of Disease, 2009 Status epilepticus (SE) is one of the most serious manifestations of epilepsy. Systemic inflammation and damage of blood-brain barrier (BBB) are etiologic cofactors in the pathogenesis of pilocarpine SE while acute osmotic disruption of the BBB is ...
Nicola Marchi +10 more
doaj +1 more source
Biochemistry and Biophysics Reports, 2021 Epilepsy is a neurological disorder of genetic or environmental origin characterized by recurrent spontaneous seizures. A rodent model of temporal lobe epilepsy is induced by a single administration of pilocarpine, a non-selective cholinergic muscarinic ...
Verónica Noches +5 more
doaj +1 more source
RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents. [PDF]
, 2014 Partial agonists are used clinically to avoid overstimulation of receptor-mediated signalling, as they produce a submaximal response even at 100% receptor occupancy.
Chen, I-Shan +3 more
core +2 more sources
Sialendoscopic management of autoimmune sialadenitis: a review of literature [PDF]
, 2017 Autoimmune diseases of major salivary glands include Sjögren's syndrome and a complex of disorders classified as immunoglobulin G4-related diseases.
DE VINCENTIIS, Marco +6 more
core +2 more sources
Frontiers in Neuroscience, 2018 Epilepsy and malnutrition constitute two worldwide health problems affecting behavior and brain function. The cholinergic agonist pilocarpine (300–380 mg/kg; single administration) reproduces the human type of temporal lobe epilepsy in rats.
Elian da Silva Francisco +1 more
doaj +1 more source
Effect of eugenol on lithium-pilocarpine model of epilepsy: behavioral, histological, and molecular changes [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Epilepsy establishment gives rise to biochemical and morphological changes in the hippocampus. Oxidative stress, morphological changes, and mossy fiber sprouting (MFS) in the hippocampus underpin the epilepsy establishment.
Sara Joushi, Mahmoud Elahdadi Salmani
doaj +1 more source
Modulation of adult-born neurons in the inflamed hippocampus. [PDF]
, 2013 Throughout life new neurons are continuously added to the hippocampal circuitry involved with spatial learning and memory. These new cells originate from neural precursors in the subgranular zone of the dentate gyrus, migrate into the granule cell layer,
Belarbi, Karim, Rosi, Susanna
core +2 more sources
The role of hippocampal NMDA receptors in long-term emotional responses following muscarinic receptor activation [PDF]
, 2016 Extensive evidence indicates the influence of the cholinergic system on emotional processing. Previous findings provided new insights into the underlying mechanisms of long-term anxiety, showing that rats injected with a single systemic dose of ...
Bicca, Maira A. +10 more
core +8 more sources
Born to Be Wild: A Case for Targeting Ectopic Adult Born Granule Cells for Seizure Control. [PDF]
, 2020 [Box: see text]
Corrubia, Lucas, Santhakumar, Viji
core