Results 111 to 120 of about 191,019 (230)
Reactive Oxygen Species in Breast Cancer: From Redox Dysregulation to ROS‐Responsive Therapeutics
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT Breast cancer is the most frequently diagnosed malignancy among women worldwide, with 2.3 million new cases and approximately 670,000 deaths reported in 2022 alone. Despite advances in therapy, metastasis and acquired drug resistance remain major clinical challenges.
Marija Nikolovska +5 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.This study explored BXSMD's effect and mechanism on rat insomnia. Pentobarbital‐induced sleep tests showed that BXSMD shortened sleep latency and prolonged sleep duration compared with the model group. The mechanism relies on MT1/MT2 as core targets, which mediate the regulation of sleep‐related molecules (CLOCK, PER1, CaMKⅡ, p‐CREB/CREB, GABARAP, and ...
Baojun Guo +4 more
wiley +1 more source
Кубанский научный медицинский вестник, 2014 Conduct a study on the morpho-functional features of the pineal gland at the simulation laundry lighting and acute stress. It was determined that in the peripheral regions of the pineal gland conditions develop functional activity, as indicated by ...
V. V. Pshychenko
doaj
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.CCH in BCCAO‐operated rats induces excessive hippocampal mitophagy and caspase‐3 upregulation. Two‐week daily melatonin treatment promotes CBF recovery, inhibits excessive mitophagy, and reduces caspase‐3 expression levels. These mechanisms may be associated with melatonin‐mediated amelioration of cognitive dysfunction in VaD rats.
Si‐jia Hou +5 more
wiley +1 more source
, 1995 [Extract] Jet lag, shiftwork, some forms of depression and ageing have one thing in common: they all involve cyclical changes linked to time. The search for the function of the human pineal gland has, in the last decade, provided some exciting insights ...
Armstrong, S.M., Graham, D.G.
core +1 more source
Regional Heterogeneity in Immunoreactive Macrophages/Microglia in the Rat Pineal Gland
, 2009 Using specific macrophage antibodies (OX-42, OX-6, ED-1 and ED-2), this study examined the distribution of macrophages/ microglia in the pineal gland of adult rats. Except for ED-2 , all antibodies labeled distinct subpopulations of macrophages/microglia
Jiang-Shieh, Ya Fen; Wu, Ching Hsiang; Chang, Min Lin; Shieh, Jeng Yung; Wen, Chen Yuan +1 more
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Targeted proteomics reveal histiocytosis‐associated neurodegeneration signatures
HemaSphere, Volume 10, Issue 9, September 2026.Abstract Neurodegeneration (ND) is a severe complication of Langerhans cell histiocytosis (LCH), yet its underlying biology and reliable biomarkers remain poorly defined. The aim of this study was to (1) gain insight into neuroimmunological mechanisms governing ND and (2) assess the clinical value of established and novel biomarkers for ND‐LCH.
Egle Kvedaraite +29 more
wiley +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.Exogenous melatonin, especially when given at night, provides strong neuroprotective benefits by influencing circadian serum melatonin levels. It inhibits PI3K‐dependent inflammatory signaling and encourages the nuclear translocation of NRF2, along with activation of the NRF2/HO‐1 antioxidant pathway.
Alaa Gamal Ahmad +4 more
wiley +1 more source
Nitric oxide synthase in the pineal gland [PDF]
, 1996 The recent discovery of nitric oxide (NO) as a biological messenger molecule with unique characteristics has opened a new field in pineal research. This free radical gas is synthesized by the enzyme nitric oxide synthase (NOS) from L-arginine.
Moller, M., Lopez-Figueroa, M.O.
core