The Role of the Mammalian Prion Protein in the Control of Sleep [PDF]
Pathogens, 2017 Sleep disruption is a prevalent clinical feature in many neurodegenerative disorders, including human prion diseases where it can be the defining dysfunction, as in the case of the “eponymous” fatal familial insomnia, or an early-stage symptom as in ...
Amber Roguski, Andrew C. Gill
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Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male Rats [PDF]
Antioxidants, 2023 Concerns have been raised regarding the potential adverse health effects of the ubiquitous herbicide glyphosate. Here, we investigated long-term effects of developmental exposure to a glyphosate-based herbicide (GBH) by analyzing serum melatonin levels ...
Daiane Cattani +4 more
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Profiling Temporal Changes of the Pineal Transcriptomes at Single Cell Level Upon Neonatal HIBD [PDF]
Frontiers in Cell and Developmental Biology, 2022 Neonatal hypoxic-ischemic brain damage (HIBD) often results in various neurological deficits. Among them, a common, yet often neglected, symptom is circadian rhythm disorders. Previous studies revealed that the occurrence of cysts in the pineal gland, an
Xin Ding +14 more
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Diurnal rhythms of pinealocyte ultrastructure, pineal serotonin content and plasma melatonin level in the domestic pig. [PDF]
Folia Histochemica et Cytobiologica, 2004 The study was conducted to investigate diurnal changes in pinealocyte ultrastructure, pineal serotonin content and plasma melatonin concentration in the domestic pig.
Marcin Nowicki +3 more
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Glia-pinealocyte network: the paracrine modulation of melatonin synthesis by tumor necrosis factor (TNF). [PDF]
PLoS ONE, 2012 The pineal gland, a circumventricular organ, plays an integrative role in defense responses. The injury-induced suppression of the pineal gland hormone, melatonin, which is triggered by darkness, allows the mounting of innate immune responses.
Sanseray da Silveira Cruz-Machado +4 more
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Cytodifferentiation of pinealocytes (I and II) and astrocyte types of mature male sheep epiphysis cerebri with special emphasis on the presence of neuronal and pigmented like cells [PDF]
Open Veterinary Journal, 2023 Background: The epiphysis cerebri (pineal gland) is a small-sized, photo neuroendocrine organ in the brain of most vertebrates. Their effect is through secretion of melatonin, a serotonin-derived hormone which is stimulated by darkness and inhibited by ...
Naief Dahran, Wael A. M. Ghonimi
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Morphology of the Human Pineal Gland Studied by Freeze-Fracturing in Scanning Electron Microscopy [PDF]
LifeThe human pineal gland is the largest producer of the hormone melatonin. Pineal acervuli (brain sand), calcified concretions in the pineal gland, have long been studied because of their association with ageing, melatonin production, and neurological ...
Simona Polakovičová +3 more
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Morten Møller: In Memoriam [PDF]
J Pineal ResJournal of Pineal Research, Volume 77, Issue 5, September 2025.
Korf H, Rath M.
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Microglia in Circumventricular Organs: The Pineal Gland Example. [PDF]
ASN Neuro, 2022 The circumventricular organs (CVOs) are unique areas within the central nervous system. They serve as a portal for the rest of the body and, as such, lack a blood-brain barrier.
Muñoz EM.
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Single-cell RNA sequencing of the mammalian pineal gland identifies two pinealocyte subtypes and cell type-specific daily patterns of gene expression. [PDF]
PLoS ONE, 2018 The vertebrate pineal gland is dedicated to the production of the hormone melatonin, which increases at night to influence circadian and seasonal rhythms. This increase is associated with dramatic changes in the pineal transcriptome.
Joseph C Mays +6 more
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