Results 21 to 30 of about 757 (161)

Recent Advances in Pineoblastoma Research: Molecular Classification, Modelling and Targetable Vulnerabilities. [PDF]

Cancers (Basel)
Pineoblastoma (PB) is a rare yet lethal pediatric brain cancer of the pineal gland, a small endocrine organ that secretes melatonin to regulate the circadian rhythm.
Jiang Z, Allkanjari MS, Chung PED, Tran H, Ghanbari-Azarnier R, Wang DY, Lin DJ, Min JY, Ben-David Y, Zacksenhaus E.   +9 more
europepmc   +3 more sources

Sex-Specific Methylomic and Transcriptomic Responses of the Avian Pineal Gland to Unpredictable Illumination Patterns. [PDF]

J Pineal Res
ABSTRACT In the production environment of chickens, exposure to unpredictable light patterns is a common painless stressor, widely used to influence growth rate and egg production efficiency. The pineal gland, a key regulator of circadian rhythms through melatonin secretion, responds to environmental light cues, and its function is modulated by ...
Pértille F, Badam T, Mitheiss N, Løtvedt P, Tsakoumis E, Gustafsson M, Coutinho LL, Jensen P, Guerrero-Bosagna C.   +8 more
europepmc   +2 more sources

Connexin36 localization to pinealocytes in the pineal gland of mouse and rat. [PDF]

Eur J Neurosci, 2017
AbstractSeveral cell types in the pineal gland are known to establish intercellular gap junctions, but the connexin constituents of those junctions have not been fully characterized. Specifically, the expression of connexin36 (Cx36) protein andmRNAhas been examined in the pineal, but the identity of cells that produce Cx36 and that form Cx36‐containing
Wang SG, Tsao DD, Vanderpool KG, Yasumura T, Rash JE, Nagy JI.   +5 more
europepmc   +4 more sources

6-Sulfatoxymelatonin predicts treatment response to fluoxetine in major depressive disorder. [PDF]

Ther Adv Psychopharmacol, 2019
Background: To date, no biomarker has been able to predict antidepressant response at an early blockade of norepinephrine or serotonin uptake. The transient nocturnal increase in plasma melatonin levels is upregulated by blocking these uptakes.
Jury Freitas J, Bertuol Xavier N, Comiran Tonon A, Carissimi A, Timm Pizutti L, Vieira Ilgenfritz CA, Pekelmann Markus R, Paz Hidalgo M.   +7 more
europepmc   +3 more sources

Study of the histomorphology of human pineal gland

National Journal of Clinical Anatomy, 2023
Introduction: Histologically, the pineal gland shows pinealocytes, glial cells, and sometimes calcific concretions. Age-related changes in these three components have been reported by various workers.
Gyanraj Singh, Sudhansu Sekhar Sethi, Sudeepa Das, Chinmayi Mohapatra   +3 more
doaj   +1 more source

Spatio-temporal dynamics of nuclear CREB1: what does it mean? [PDF]

, 2022
In the mammalian pineal gland (PG), cyclic AMP responsive element-binding protein 1 (CREB1) participates in the nocturnal melatonin synthesis that rhythmically modulates physiology and behavior.
Farías Altamirano, Luz Estefanía, Freites, Carlos Leandro, Guido, Mario Eduardo, Ibañez, Jorge Ernesto, Muñoz, Estela Maris, Vásquez, Elena   +5 more
core   +1 more source

CREB1 spatio-temporal dynamics within the rat pineal gland [PDF]

, 2023
In the rat pineal gland (PG), cyclic AMP responsive element-binding protein 1 (CREB1) participates in the nocturnal melatonin synthesis that rhythmically modulates physiology and behavior.
Farías Altamirano, Luz Estefanía, Freites, Carlos Leandro, Guido, Mario Eduardo, Ibañez, Jorge Ernesto, Muñoz, Estela Maris, Vásquez, Elena   +5 more
core   +1 more source

Epiphysis morphology under light and radiation exposure in experiment

Бюллетень сибирской медицины, 2003
Epiphysis is an organ of the control of biorhythms and adaptogenesis connected with photoperiodism. To evaluate photoradiomodificating effect and conarium plasticity using the methods of light and electron microscopy, there have been analyzed changes in ...
S. V. Logvinov, A. V. Gerasimov, V. P. Kostyuchenko   +2 more
doaj   +1 more source

Cellular basis of pineal gland development: Emerging role of microglia as phenotype regulator [PDF]

, 2016
The adult pineal gland is composed of pinealocytes, astrocytes, microglia, and other interstitial cells that have been described in detail. However, factors that contribute to pineal development have not been fully elucidated, nor have pineal cell ...
Ibañez Rodriguez, María Paula, Muñoz, Estela Maris, Noctor, Stephen C.   +2 more
core   +5 more sources

The ISL LIM‐homeobox 2 transcription factor is negatively regulated by circadian adrenergic signaling to repress the expression of Aanat in pinealocytes of the rat pineal gland

Journal of Pineal Research, Volume 75, Issue 4, December 2023., 2023
Abstract Melatonin is synthesized in the pineal gland during nighttime in response to nocturnal increase in the activity of the enzyme aralkylamine N‐acetyltransferase (AANAT), the transcription of which is modulated by several homeodomain transcription factors. Recent work suggests that the homeodomain transcription factor ISL LIM homeobox 2 (ISL2) is
Kuno M.‐J. Mattern, Aurea S. Blancas‐Velázquez, Mikaella T. Ngo, Signe Bille, Henrik Hertz, Tenna Bering, Martin F. Rath   +6 more
wiley   +1 more source