Results 51 to 60 of about 757 (161)

Seizure‐related death exhibits a circadian rhythm independent of seizure timing or sleep in a mouse model of Dravet syndrome

The Journal of Physiology, Volume 603, Issue 12, Page 3571-3587, 15 June 2025.
Abstract figure legend Sudden unexpected death in epilepsy (SUDEP) frequently occurs at night when humans are asleep. Nocturnal mouse models of seizure‐associated death also exhibit higher mortality during the night. This nighttime risk of death may be under the regulation of independent circadian and sleep state‐dependent processes.
Benjamin L. Kreitlow, Ana T. Novella‐Maciel, Ariana M. Hernández Vázquez, Gordon F. Buchanan   +3 more
wiley   +1 more source

Ceramide inhibits the outward potassium current in rat pinealocytes [PDF]

Journal of Neurochemistry, 2001
In the present study, we investigated the effect of ceramide on the outward K+ current in rat pinealocytes using whole cell and single channel recordings. Three components of the whole cell outward K+ current were separated, an iberiotoxin (IBTX)‐sensitive K+ current (IKCa), a transient A current (IA) and a delayed rectifier current (IK).
B. Li, Constance L. Chik, A. K. Ho, Edward Karpinski   +3 more
openaire   +3 more sources

Luminal acidification of diverse organelles by V-ATPase in animal cells [PDF]

, 2000
Eukaryotic cells contain organelles bounded by a single membrane in the cytoplasm. These organelles have differentiated to carry out various functions in the pathways of endocytosis and exocytosis. Their lumina are acidic, with pH ranging from 4.5 to 6.5.
Futai, Masamitsu, Kanazawa, Hiroshi, Moriyama, Yoshinori, Oka, Toshihiko, Sun-Wada, Ge-hong, Wada, Yoh   +5 more
core  

Molecular Basis for Defining the Pineal Gland and Pinealocytes as Targets for Tumor Necrosis Factor [PDF]

, 2010
The pineal gland, the gland that translates darkness into an endocrine signal by releasing melatonin at night, is now considered a key player in the mounting of an innate immune response.
Carvalho-Sousa, Claudia Emanuele, Cecon, Erika, da Silveira Cruz-Machado, Sanseray, Fernandes, Pedro A. C. M., Markus, Regina P., Muxel, Sandra M., Pinato, Luciana, Tamura, Eduardo Koji   +7 more
core   +3 more sources

Expanding the scope of mast cell disease: Does mast cell‐derived TNF play a role in immune‐mediated chronic illness and autoimmunity?

Rheumatology &Autoimmunity, Volume 4, Issue 4, Page 218-225, December 2024.
Mast cells (MCs) and MC‐derived tumor necrosis factor (TNF) are important in chronic inflammatory and autoimmune diseases and post‐viral syndromes, having important mechanisms of action, and therapeutic potential. MC and MC‐derived TNF activation are involved in conditions like COVID‐19, and neuroinflammation, linking TNF to various pathological ...
Rachel da Silveira Gorman, Iffath Unissa Syed   +1 more
wiley   +1 more source

Embryonal and pineal tumours

Cytopathology, Volume 35, Issue 5, Page 561-571, September 2024.
Abstract Embryonal and pineal tumours represent a diverse group of central nervous system (CNS) neoplasms. While many of the small round blue cell tumours that make up the embryonal neoplasms share similar histologic qualities, there are several morphologic and cytologic characteristics that are useful in distinguishing different tumour types ...
Joseph Reznicek, Nima Sharifai, Pouya Jamshidi, Nitin Wadhwani, Jared T. Ahrendsen   +4 more
wiley   +1 more source

Mouse Models in Circadian Rhythm and Melatonin Research

Journal of Pineal Research, Volume 76, Issue 5, August 2024.
ABSTRACT This contribution reviews the role of inbred and transgenic mouse strains for deciphering the mammalian melatoninergic and circadian system. It focusses on the pineal organ as melatonin factory and two major targets of the melatoninergic system, the suprachiasmatic nuclei (SCN) and the hypophysial pars tuberalis (PT).
Horst‐Werner Korf, Charlotte von Gall
wiley   +1 more source

Melatonin and Seasonal Synchrony in Mammals

Journal of Pineal Research, Volume 76, Issue 5, August 2024.
ABSTRACT In mammals, seasonal opportunities and challenges are anticipated through programmed changes in physiology and behavior. Appropriate anticipatory timing depends on synchronization to the external solar year, achieved through the use of day length (photoperiod) as a synchronizing signal.
David G. Hazlerigg, Valérie Simonneaux, Hugues Dardente   +2 more
wiley   +1 more source

MICROCYLINDERS WITHIN MITOCHONDRIAL CRISTAE IN THE RAT PINEALOCYTE [PDF]

The Journal of Cell Biology, 1965
A minute cylindrical structure with a dense core, designated as "microcylinder," has been observed within enlarged spaces of mitochondrial cristae in pinealocytes of some adult rats (osmium tetroxide fixed, methacrylate embedded). The microcylinders are 270 to 330 A in diameter and of indeterminate length.
openaire   +3 more sources

A Seasonal and Age-Related Study of Interstitial Cells in the Pineal Gland of Male Viscacha (Lagostomus maximus maximus) [PDF]

, 2017
The pineal gland of viscacha exhibits histophysiological variations throughout the year, with periods of maximal activity in winter and minimal activity in summer. The aim of this work is to analyze the interstitial cells (IC) in the pineal gland of male
Acosta, Acosta, Aguilera-Merlo, Aguilera-Merlo, Borregón, Boya, Böni, Calvo, Calvo, Calvo, Calvo, Calvo, Cernuda-Cernuda, Chaves, Cruceño, Dahl, Dominguez, Donato, Donato, Donato, Eng, Eng, Filippa, Filippa, Franco, Fuentes, Fuentes, Fuentes, Girod, Gonzales, Haimoto, Hernández Díaz, Huang, Inagaki, Ivaska, Jackson, Lehtonen, Liedtke, Llanos, Lopez-Egido, López-Muñoz, McCall, Muñoz, Muñoz, Muñoz, Muñoz, Møller, Nieminen, Oshima, Piezzi, Rambotti, Redford, Redondo, Redondo, Regodón, Rodriguez, Runembert, Safwat, Schachner, Schietke, Shibuki, Suzuki, Tolstonog, Tolstonog, Vollrath, Welsh, Yang   +66 more
core   +1 more source