Results 31 to 40 of about 498,615 (306)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Huai‐Ping Cong [PDF]

open access: yesChemPlusChem, 2018
"My favorite time of day is … when I discuss new ideas and experimental results with my students. The most important lesson I have learnt … is to never give up and to maintain my enthusiasm for research." This and more about Huai-Ping Cong can be found on page 94.
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

gjacopo/PING: Pre-release of PING software

open access: yes, 2017
<p>This is a pre-release of PING software developed and deployed in data production environments.</p> <p>This software offers a collection of macro/function utilities implemented in R/SAS/Stata for statistical data handling and ...
Jacopo Grazzini   +9 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Ping modo gráfico com Software PING TEST

open access: yes, 2014
Mostra uma ferramenta chamada Ping Test que dá um "Ping" através de uma interface gráficaEducação Profissional::Informação e ...
Ramos, Leandro
core   +1 more source

A New Key Delivery Method in Wireless Network

open access: yesDüzce Üniversitesi Bilim ve Teknoloji Dergisi, 2017
The development of networking technologies and the increase of digital devices have made multimedia transmission quick and easy. However, digital data transmission over open communication channels has introduced a number of security implications, such as
Çağatay Ay
doaj  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Container Relocation and Retrieval Tradeoffs Minimizing Schedule Deviations and Relocations

open access: yesIEEE Open Journal of Intelligent Transportation Systems
Ports are striving to improve operational efficiency in the context of constantly growing volumes of trade. In this context, port terminal storage yard operation is key, since complexity and poor coordination lead to containers stacked without ...
Robert Klar   +3 more
doaj   +1 more source

Short‐term load forecasting based on a generalized regression neural network optimized by an improved sparrow search algorithm using the empirical wavelet decomposition method

open access: yesEnergy Science & Engineering, 2023
With the development of the electric market, electric load forecasting has been increasingly pursued by many scholars. Because the electric load is affected by many factors, it is characterized by volatility and uncertainty, and it cannot be forecasted ...
Guo‐Feng Fan   +4 more
doaj   +1 more source

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