Results 101 to 110 of about 23,315 (198)

Medications That Regulate Pregnane X Receptor: A Systematic Review of Current Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
PRISMA 2020 flow diagram of study selection for this systematic review of medications that regulate the pregnane X receptor (PXR), from 12 236 records screened to 101 included studies. ABSTRACT The pregnane X receptor (PXR) gene encodes a ligand‐activated protein involved with the metabolism and excretion of drugs, toxins, and other xenobiotics.
Petra Czarniak, Rachael Moorin, Jeff Hughes, Karl Gruber, David Youens   +4 more
wiley   +1 more source

Modulation of TLR4 and upregulation of HO-1 & PPAR-γ by Pioglitazone ameliorates methotrexate-induced liver damage in rats

Future Journal of Pharmaceutical Sciences
Background Methotrexate is a frequently prescribed antifolate immunosuppressant and antineoplastic agent that has been associated with serious systemic adverse effects including hepatotoxicity.
Rasha Abdelhady, Rana M. Abdelnaby, Mohamed Elsayed Mohamed Amer, Nancy S. Younis, Ebtehal Mohammad Fikry   +4 more
doaj   +1 more source

Schedule‐dependent neuroprotection by pioglitazone in a novel model of α‐synucleinopathy in rats: Integrated behavioural and histological outcomes

British Journal of Pharmacology, Volume 183, Issue 15, Page 4227-4245, August 2026.
Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda, Marcos M. Villegas‐Rojas, Isaac Pérez‐Segura, Maricela Espino‐Cambrón, Daniel Martinez‐Fong, Luis O. Soto‐Rojas   +5 more
wiley   +1 more source

Insulin Sensitivity and Beta Cell Function With Macupatide Alone or With Dulaglutide in Type 2 Diabetes: A Phase 1b, Randomised Controlled Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7196-7206, August 2026.
ABSTRACT Aims This Phase 1b, randomised, double‐blind clinical trial investigated the contribution of glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) to insulin sensitivity and secretion in people with type 2 diabetes (T2D) on metformin. Materials and Methods Participants were randomised to receive the long‐acting
Tim Heise, Eric Zijlstra, Andrea Mari, William C. Roell, Kieren J. Mather, Axel Haupt, Panagiotis Flevaris, Ran Liao, Laiyi Chua, Charles Harris, Edward J. Pratt   +10 more
wiley   +1 more source

Association of Post‐Oral Glucose Tolerance Test Hypoglycaemia With Clinical Features, Incident Diabetes and Mortality in the Di@bet.es Cohort

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7430-7442, August 2026.
ABSTRACT Aims To investigate the association of post‐oral glucose tolerance test (OGTT) hypoglycaemia with clinical features, incident diabetes and mortality. Materials and Methods This population‐based cohort study included 2924 adults (median age 49 years, 1680 women) without known diabetes who underwent a 75‐g OGTT as part of the Di@bet.es Study ...
Tomás González‐Vidal, Gemma Rojo‐Martínez, Sergio Valdés, Eva García‐Escobar, Josep Franch‐Nadal, Alfonso Calle‐Pascual, Luis Castaño, Felipe Javier Chaves, Eduard Montanya, Elsa Villa‐Fernández, Ana Victoria García, Miguel García‐Villarino, Carmen Lambert, Edelmiro Menéndez‐Torre, Elías Delgado   +14 more
wiley   +1 more source

Glycemic Normalization Immediately Following Vertical Sleeve Gastrectomy in Adolescents With Type 2 Diabetes From the ST2OMP Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7555-7561, August 2026.
ABSTRACT Aim Youth‐onset type 2 diabetes and obesity are rising public health burdens. While newer type 2 diabetes medications lower HbA1c, their impact on paediatric weight loss is inconsistent. In contrast, bariatric surgery improves glycemia and weight in youth and adults, though glycemia post‐vertical sleeve gastrectomy (VSG), now the predominant ...
Natalie Segev, Kristen J. Nadeau, Megan Kelsey, Lisa R. Schaaf, Amy Baumgartner, Allen Riegler, Kelly Wiitala, Todd M. Jenkins, Stavra A. Xanthakos, Michael A. Helmrath, Thomas H. Inge, Amy Sanghavi Shah   +11 more
wiley   +1 more source

Contemporary Management of Aortic Stenosis: Timing of Intervention and Lifetime Valve Management

European Journal of Clinical Investigation, Volume 56, Issue 8, August 2026.
As transcatheter treatment expands to younger and lower‐risk patients, aortic stenosis management is evolving from a single procedure to lifelong valve care. This review highlights the key challenges across the patient journey, from timely diagnosis and optimal intervention to durable valve performance, long‐term surveillance, and repeat intervention ...
Ottavia Cozzi, Thomas Pilgrim
wiley   +1 more source

Primary cardiovascular preventive effect of thiazolidinedione in adults with type 2 diabetes: A nationwide cohort study in Korea

Journal of Diabetes Investigation, Volume 17, Issue 8, Page 1367-1378, August 2026.
Among Korean adults with type 2 diabetes and no prior cardiovascular disease, thiazolidinedione use was associated with a lower risk of the primary composite outcome of stroke, myocardial infarction, hospitalization for heart failure, and all‐cause mortality compared to dipeptidyl peptidase‐4 inhibitor use. ABSTRACT Background Thiazolidinediones (TZDs)
Yun Young Choi, Jimin Jeon, Minyoul Baik, Joonsang Yoo, Jinkwon Kim   +4 more
wiley   +1 more source

Dapagliflozin does not impair microvascular hemorheology in type 2 diabetes mellitus: A multicenter randomized controlled trial (D‐PATH study)

Journal of Diabetes Investigation, Volume 17, Issue 8, Page 1322-1334, August 2026.
Graphical abstract illustrating the study design, physiological rationale, and key findings of the D‐PATH trial. Dapagliflozin, an SGLT2 inhibitor, lowers HbA1c and body weight while increasing hematocrit and erythropoietin levels. Although an elevated hematocrit could theoretically increase blood viscosity and impair microcirculatory flow, ex vivo ...
Yuki Nakatani, Nobuyuki Banba, Shoya Ono, Tomoki Turumi, Megumi Hoshiai, Takushi Sugiyama, Takashi Tomoe, Hajime Tamiya, Naoyuki Otani, Hiroyuki Sugimura, Hidekazu Ikemiyagi, Yusuke Ohya, Koji Yokokawa, Shinichiro Ueda, Yoshimasa Aso, Yasuhiro Maejima, Takanori Yasu   +16 more
wiley   +1 more source

Estradiol Replacement Modulates Synaptic Transmission‐Related Proteins in the Hippocampus of Ovariectomized Rats: An Exploratory Proteomic Approach

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
The estrogen deficiency in the hippocampus influences cognitive functions and control of food intake. Hippocampi of female rats, either control or ovariectomized, with or without estrogen replacement, were submitted to LC–MS/MS and analysis of pathway‐based functional roles of proteins affected by estrogen deficiency and replacement.
Amanda Paula Pedroso, Adriana Pereira Souza, Guilherme Araújo Câmara, Meira Maria Forcellini Machado, Valter Tadeu Boldarine, Lila Missae Oyama, Mônica Marques Telles, Alexandre Keiji Tashima, Eliane Beraldi Ribeiro   +8 more
wiley   +1 more source