Results 61 to 70 of about 23,348 (143)
Delta-9-tetrahydrocannabinol protects against MPP+ toxicity in SH-SY5Y cells by restoring proteins involved in mitochondrial biogenesis [PDF]
, 2016 This project was supported through a studentship awarded by the Plymouth University Peninsula Schools of Medicine and Dentistry.Proliferator-activated receptor γ (PPARγ) activation can result in transcription of proteins involved in oxidative stress ...
Carroll, CB +5 more
core +3 more sources
Pioglitazone Enhances Cytosolic Lipolysis, β-oxidation and Autophagy to Ameliorate Hepatic Steatosis
Scientific Reports, 2017 Non-alcoholic fatty liver disease closely contributes to the development of obesity and insulin resistance. Even though pioglitazone has been reported to effectively lessen hepatic steatosis in human studies, its molecular mechanism remains unclear. This
Pi-Jung Hsiao +5 more
doaj +1 more source
PPAR Gamma Receptor: A Novel Target to Improve Morbidity in Preterm Babies
Pharmaceuticals, 2023 Worldwide, three-quarters of a million babies are born extremely preterm (
Suresh Victor +3 more
doaj +1 more source
Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine [PDF]
, 2019 Type 2 diabetes mellitus (T2DM) is a chronic disease that has reached the levels of a global epidemic. In order to achieve optimal glucose control, it is often necessary to rely on combination therapy of multiple drugs or insulin because uncontrolled ...
Andreozzi, F, Mannino, Gc, Sesti, G
core +1 more source
Obesity, EarlyView.Increased hepatic PAFR expression in MASLD is associated with histological disease severity and may contribute to progression through platelet activation, whereas circulating Lp‐PLA2 levels lack discriminatory value as a noninvasive biomarker. ABSTRACT Objective This study aimed to investigate the platelet‐activating factor (PAF) pathway in obesity ...
Joan Duran‐Bertran +11 more
wiley +1 more source
A pilot randomized controlled trial of pioglitazone for the treatment of poorly controlled asthma in obesity [PDF]
, 2015 Background: Obese asthmatics tend to have poorly controlled asthma, and resistance to standard asthma controller medications. The purpose of this study was to determine the efficacy of pioglitazone, an anti-diabetic medication which can alter circulating
Black, K +5 more
core +1 more source
Sleep Research, EarlyView.The causal roles of metabolic traits in mediating the effects of insomnia on CVDs. CAD, coronary artery disease; HbA1c, hemoglobin A1c; HDL‐C, high‐density lipoprotein cholesterol; IR, insulin resistance; MI, myocardial infarction; TG, triglyceride; T2DM, type 2 diabetes.
Binhe Yu +12 more
wiley +1 more source
Frontiers in Pharmacology, 2018 Renal ischemia-reperfusion injury (IRI) is a major cause of acute renal failure. Our previous studies have shown that pioglitazone, a peroxisome proliferators-activated receptor (PPAR)-γ agonist used in type 2 diabetes, protects against renal IRI ...
Wenlin Chen +7 more
doaj +1 more source
The PPARγ Agonist Rosiglitazone Suppresses Syngeneic Mouse SCC (Squamous Cell Carcinoma) Tumor Growth through an Immune-Mediated Mechanism [PDF]
, 2019 Recent evidence suggests that PPARγ agonists may promote anti-tumor immunity. We show that immunogenic PDV cutaneous squamous cell carcinoma (CSCC) tumors are rejected when injected intradermally at a low cell number (1 × 106) into immune competent ...
Derr-Yellin, Ethel +4 more
core +1 more source
VIEW, EarlyView.AA‐Exos promotes angiogenesis and accelerates diabetic wound healing by activating the PI3K/AKT/mTOR pathway. Abstract Diabetic wounds are common and challenging complications of diabetes, characterized by delayed healing and an increased risk of infection.
Yujiao Cai +7 more
wiley +1 more source