Results 71 to 80 of about 23,850 (163)

AMPK‐Mediated Lipid Metabolic Reprogramming in Cancer: From Mechanisms to Targeted Therapies

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT AMP‐activated protein kinase (AMPK), a key regulator of cellular energy metabolism, is activated under conditions of energy stress to restore metabolic homeostasis by promoting catabolic pathways and inhibiting anabolic processes such as lipid synthesis. Multiple key molecules involved in lipid metabolism are regulated by AMPK, and its role in
Yuying Chen, Wen Liu, Bing Luo
wiley   +1 more source

Cost-effectiveness of pioglitazone in type 2 diabetes patients with a history of macrovascular disease: a German perspective

Cost Effectiveness and Resource Allocation, 2009
Background The aim of this study was to project health-economic outcomes relevant to the German setting for the addition of pioglitazone to existing treatment regimens in patients with type 2 diabetes, evidence of macrovascular disease and at high risk ...
Massi-Benedetti Massimo, Erny-Albrecht Katrina M, Goodall Gordon, Scherbaum Werner A, Erdmann Erland, Valentine William J   +5 more
doaj   +1 more source

Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 966-978, October 2026.
This study investigated genetic determinants of the pharmacokinetics of the CYP2C8 index drugs repaglinide and gemfibrozil, and their interaction in healthy participants. Sequencing data from a study with montelukast revealed a novel functional CYP2C8 allele (rs2071426, CYP2C8*19), predicted to create an intronic splice donor site.
Anssi J. H. Mykkänen, Päivi Hirvensalo, Kathrin Klein, Dorota Kaminska, Markus Grube, Tuija Tapaninen, Johanna I. Kiiski, Mikko Neuvonen, Ville T. Männistö, Jussi Pihlajamäki, Mladen Tzvetkov, Matthias Schwab, Aleksi Tornio, Janne T. Backman, Mikko Niemi   +14 more
wiley   +1 more source

Efficacy of pioglitazone in treatment of metabolic dysfunction-associated fatty liver disease

Al-Azhar Assiut Medical Journal
Background and aim Nonalcoholic fatty liver disease has emerged as a major public health challenge, with limited approved pharmacological therapies.
Mahmoud M. Khafagi, Hamdy M. Moustafa, Ahmed A. Ahmed, Mohamed A. Bashir, Abdelghany Aish, Amro M. Hassan   +5 more
doaj   +1 more source

Markers of Systemic Metabolic Dysfunction in Vitiligo and Their Potential Role in Disease Pathogenesis: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Vitiligo is a chronic autoimmune disease characterized by the progressive destruction of melanocytes, resulting in depigmented skin macules. While traditionally viewed as a cutaneous disorder driven by a specific CD8+ T cell‐mediated interferon‐γ (IFN‐γ) signature, emerging research suggests that vitiligo may be a systemic condition
Federica Papaccio, Simona Scano, Barbara Bellei   +2 more
wiley   +1 more source

Glucagon‐Like Peptide‐1 Agonists and the Incidence of Atrial Fibrillation in Obese Patients With Heart Failure With Preserved Ejection Fraction and No Diabetes

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
Among obese, non‐diabetic patients with HFpEF, GLP‐1 RA therapy was not significantly associated with incident atrial fibrillation but was associated with lower all‐cause mortality. Prospective studies are needed to clarify the potential role of GLP‐1 RAs in AF prevention. ABSTRACT Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) reduce
Farah Rassam, Esteban Kosak Lopez, Sarah Sass, Thitiphan Srikulmontri, Evan Isaacs, John Malin, Phuuwadith Wattanachayakul, Olayinka Afolabi‐Brown   +7 more
wiley   +1 more source

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies

MedComm, Volume 7, Issue 10, October 2026.
Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng, Qi Qin, Fang Wang, Kaiyuan Zhang, Zhihua Li, Junlei Chang, Min Yu, Fuyou Guo   +7 more
wiley   +1 more source

Effects of Resveratrol on pharmacokinetics and pharmacodynamics of Pioglitazone in Diabetic rats [PDF]

Perspectives In Medical Research, 2017
Introduction: Diabetes is a group of metabolic disorders characterized by a chronic hyperglycaemic condition resulting from insufficient action of insulin.
Raju Devde1 , Narasimha Reddy Y2 , Sravanthi K3 , Abid Ali4 , Imran Khan5
doaj  

An LCK/PPARG/SCD Lipid Metabolism Axis Promotes Invasion in Human Oral Cancer

MedComm, Volume 7, Issue 10, October 2026.
Oral squamous cell carcinoma (OSCC) progression is driven by invasive tumor‐cell phenotypes, for which effective targeted therapies remain limited. Here, we identify a tumor‐cell‐intrinsic LCK/PPARG/SCD axis, in which LCK regulates PPARG expression and H3K27 acetylation, while PPARG promotes lipid remodeling and SCD‐dependent fatty acid desaturation to
Jonas Pyko, Tamara Tomin, Markus Glaß, Lisa Müller, Jana Macho, Matthias Schittmayer, Monika Haemmerle, Ruth Birner‐Gruenberger, Tony Gutschner   +8 more
wiley   +1 more source