Results 111 to 120 of about 77,758 (248)

Results of A Local Combination Therapy Antibiogram For \u3cem\u3ePseudomonas Aeruginosa\u3c/em\u3e Isolates: Is Double Worth The Trouble? [PDF]

, 2017
Purpose: To determine the frequency at which fluoroquinolones and aminoglycosides demonstrate in vitro activity against non-urinary, non-skin/skin structure Pseudomonas aeruginosa isolates exhibiting decreased susceptibilities to one or more β-lactam ...
Davis, Jim, Dilworth, Thomas J., Elshaboury, Ramy, Munson, Erik, Song, Matthew   +4 more
core   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

Optimising Meropenem and Piperacillin Dosing in Patients Undergoing Extracorporeal Membrane Oxygenation Without Renal Dysfunction (MEPIMEX)

Antibiotics
Background/Objectives: Antibiotic pharmacokinetics (PK) and pharmacodynamics (PD) are altered during extracorporeal membrane oxygenation (ECMO). Meropenem and piperacillin are among the most commonly prescribed antibiotics for infections in this ...
Mar Ronda, M Paz Fuset, Erika Esteve-Pitarch, Josep Llop, Victor Daniel Gumucio-Sanguino, Evelyn Shaw, Daniel Marco Mula, Kristel Maisterra-Santos, Joan Sabater, Xose L. Pérez, Sara Cobo-Sacristan, Raül Rigo, Fe Tubau, Jordi Carratalà, Helena Colom-Codina, Ariadna Padullés   +15 more
doaj   +1 more source

Rapid onset severe thrombocytopenia following reexposure to piperacillin-tazobactam: report of two cases and review of the literature

Platelets, 2018
Pipercillin-tazobactam is a frequently used antibiotic that has a broad spectrum of antibacterial activity. The development of severe thrombocytopenia following the use of piperacillin-tazobactam is unusual.
Musa Alzahrani, Ibrahim Alrumaih, Fahad Alhamad, Ahmed Abdel Warith   +3 more
doaj   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Population Pharmacokinetic Modeling of Piperacillin/Tazobactam in Healthy Adults and Exploration of Optimal Dosing Strategies

Pharmaceuticals
Background/Objectives: Current dosing recommendations for piperacillin/tazobactam suggest adjustments only for patients with creatinine clearance (CrCl) below 40 mL/min, potentially neglecting the variability in drug exposure among patients with a CrCl ...
Yun Jung Lee, Gaeun Kang, Dae Young Zang, Dong Hwan Lee   +3 more
doaj   +1 more source

Perioperative Piperacillin/Tazobactam Reduces Early Onset SSI in Preirradiated Patients Undergoing Microvascular Head and Neck Reconstruction

Head &Neck, Volume 48, Issue 6, Page 1519-1528, June 2026.
ABSTRACT Background Preirradiated patients undergoing microvascular head and neck reconstruction for tumor recurrence or osteoradionecrosis (ORN) face surgical site infection (SSI) rates exceeding 30%. The impact of perioperative extended‐spectrum antibiotic coverage remains unclear. This study hypothesizes that calculated prophylaxis with piperacillin/
Johannes G. Schuderer, Florian Hoferer, Jonas Eichberger, Mathias Fiedler, André Gessner, Stilla Bauernfeind, Maximilian Gottsauner, Felix Nieberle, Michael Maurer, Johannes K. Meier, Torsten E. Reichert, Tobias Ettl   +11 more
wiley   +1 more source

Piperacillin-Associated Pulmonary Infiltrates with Eosinophilia: A Case Report

Canadian Respiratory Journal, 2010
A case of pulmonary infiltrates with eosinophilia attributed to piperacillin/tazobactam therapy is described. A 54-year-old woman was treated for a suspected severe urinary tract infection with piperacillin/tazobactam.
Olivia Ling-I Tseng, John Thomas Kelsall, Pearce George Wilcox   +2 more
doaj   +1 more source

Gut Microbiota as a Key Modulator in the Pathophysiology of Sepsis: SURVEIL Project

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Longitudinal profiling of 132 hospitalized patients reveals that age, colonization status, and sepsis interact to shape gut microbiota diversity and composition. Sepsis is associated with reduced alpha diversity, beta‐diversity shifts, functional predictions (methanogenesis, nitrate/sulfate respiration), and partial MDR overlap with bloodstream ...
Chiara Bazzano, Alice Caramaschi, Nadia Massa, Silvio Collani, Marta Mellai, Nadia Barizzone, Andrea Rocchetti, Paolo Bottino, Maria Simona Caroppo, Valeria Bonato, Rosanna Vaschetto, Sara Scaglione, Alessia Francese, Narges Gholami, Claudio Caria, Paola Bianchi, Cristiano Lauritano, Luigi Castello, Annalisa Roveta, Antonio Maconi, Stefano Andreoni, Sandra Dalfonso, Elisa Bona   +22 more
wiley   +1 more source

Hidden Fungal Diversity of the Precious Mediterranean Red Coral Corallium rubrum

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
This study reveals diverse cultivable fungi associated with the red coral Corallium rubrum, highlighting both potentially beneficial and pathogenic species. These findings emphasize the biotechnological relevance and ecological impact of coral‐associated fungi, especially as climate change may increase disease risks.
Camille Prioux, Marina Carrasco‐Acosta, Valeria Prigione, Francesco Venice, Romie Tignat‐Perrier, Denis Allemand, Christine Ferrier‐Pagès, Giovanna Cristina Varese   +7 more
wiley   +1 more source