Results 291 to 300 of about 43,723 (349)

New Structure Activity Relationship Insight into the Role of the C-3 Extension on Rifamycin Antimycobacterial Activity. [PDF]

ChemMedChem
Veale CGL, Smolarz E, Leśniewska A, Pyta K, Przybylski P.   +4 more
europepmc   +1 more source

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Discovery, bioactivity and biosynthesis of fungal piperazines.

Natural product reports (Print), 2022
Covering: up to the end of July, 2022Fungi are prolific producers of piperazine alkaloids, which have been shown to exhibit an array of remarkable biological activities.
Rui Wang, Andrew M. Piggott, Y. Chooi, Hang Li   +3 more
semanticscholar   +1 more source

Chrysosporazines F-M: P-Glycoprotein Inhibitory Phenylpropanoid Piperazines from an Australian Marine Fish Derived Fungus, Chrysosporium sp. CMB-F294.

Journal of Natural Products, 2020
Chemical analysis of the fungus Chrysosporium sp. CMB-F294 isolated from the gastrointestinal tract of a market-purchased specimen of Mugil mullet yielded eight new alkaloids, belonging to a rare class of phenylpropanoid piperazines. Chrysosporazines F-M
Osama G. Mohamed, A. Salim, Zeinab G. Khalil, Ahmed H. Elbanna, P. Bernhardt, R. Capon   +5 more
semanticscholar   +1 more source

Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines.

Journal of Medicinal Chemistry, 2018
In this article, we report our investigation of a phenomenon by which bridging morpholines across the ring with one-carbon tethers leads to a counterintuitive reduction in lipophilicity.
S. Degorce, M. Bodnarchuk, I. Cumming, James S. Scott   +3 more
semanticscholar   +1 more source

Practical and scalable synthesis of orthogonally protected-2-substituted chiral piperazines.

Organic and biomolecular chemistry, 2020
A synthetic route to orthogonally protected, enantiomerically pure 2-substituted piperazines is described. Starting from α-amino acids, within four steps chiral 2-substituted piperazines are obtained.
S. Chamakuri, Manuj M. Shah, David C H Yang, C. Santini, D. Young   +4 more
semanticscholar   +1 more source

Simultaneous determination of 75 abuse drugs including amphetamines, benzodiazepines, cocaine, opioids, piperazines, zolpidem and metabolites in human hair samples using liquid chromatography-tandem mass spectrometry.

Biomedical chromotography, 2019
A liquid chromatography-tandem mass spectrometric method for the simultaneous determination of 75 abuse drugs and metabolites, including 19 benzodiazepines, 19 amphetamines, two opiates, eight opioids, cocaine, lysergic acid diethylamide, zolpidem, three
Yongho Shin, T. Y. Kong, J. Cheong, Jin Young Kim, Jae Il Lee, H. Lee   +5 more
semanticscholar   +1 more source

Chrysosporazines A-E: P-Glycoprotein Inhibitory Piperazines from an Australian Marine Fish Gastrointestinal Tract-Derived Fungus, Chrysosporium sp. CMB-F214.

Organic Letters, 2019
Chemical analysis of Chrysosporium sp. CMB-F214, yielded five new piperazines, chrysosporazines A-E (1-5), with structures assigned by spectroscopic and X-ray analyses and biosynthetic considerations.
Ahmed H. Elbanna, Zeinab G. Khalil, P. Bernhardt, R. Capon   +3 more
semanticscholar   +1 more source

The medicinal chemistry of piperazines: A review

Chemical Biology and Drug Design
The versatile basic structure of piperazine allows for the development and production of newer bioactive molecules that can be used to treat a wide range of diseases.
Md Faizan, Rajnish Kumar, Avijit Mazumder, Salahuddin, Neelima Kukreti, Arvind Kumar, M. Chaitanya   +6 more
semanticscholar   +1 more source

High Catalytic Activity of Pd Nanoparticles Synthesized from Green Alga Chlorella vulgaris in Buchwald-hartwig Synthesis of N-Aryl Piperazines

, 2019
The N-aryl piperazines are an important component of many drug products used for the treatment of malaria, depression, anxiety and Parkinson diseases. Buchwald-Hartwig amination is the latest and well-known reaction for Pd catalyzed direct synthesis of
V. Mishra, Anju Arya, T. Chundawat
semanticscholar   +1 more source

Synthesis of N-Pyrrolyl(furanyl)-Substituted Piperazines, 1,4-Dizepanes, and 1,4-Diazocanes.

Journal of Organic Chemistry, 2019
The synthetic potential of 5-bromo-1,1,1-trifluoro-4-methoxypent-3-en-2-one toward the catalyst-free synthesis of N-pyrrolyl(furanyl)-piperazines, 1,4-diazepanes, and 1,4-diazocanes through a telescoped protocol is reported.
Mateus Mittersteiner, Valquiria P. Andrade, Lucimara L. Zachow, C. Frizzo, H. Bonacorso, M. Martins, N. Zanatta   +6 more
semanticscholar   +1 more source