Results 201 to 210 of about 76,241 (267)

RrMYB2 Regulates Drought Stress via RrJMJ12‐Dependent Epigenetic Modification in Rosa rugosa

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1578-1594, March 2026.
ABSTRACT Rosa rugosa (R. rugosa), an economically important crop valued for its fragrance and medicinal properties, is highly susceptible to drought stress under open‐field cultivation. However, the molecular mechanisms underlying its drought response remain largely unexplored.
Mengjuan Bai, Yating Yang, Yunfeng Gao, Mengmeng Xu, Qianxiang Zhang, Shuo Liu, Jun Lu, Jianwen Wang, Changquan Wang, Liguo Feng   +9 more
wiley   +1 more source

Development of Novel Proline- and Pipecolic Acid-Based Allosteric Inhibitors of Dengue and Zika Virus NS2B/NS3 Protease. [PDF]

Pharmaceuticals (Basel)
Starvaggi J, Di Chio C, Lang J, Belgiovine V, Trisciuzzi D, Previti S, Klein C, Nicolotti O, Di Maro S, Zappalà M, Ettari R.   +10 more
europepmc   +1 more source

The effect of mitoTEMPO on the development of hypoxia‐induced pulmonary hypertension in male mice

Physiological Reports, Volume 14, Issue 5, March 2026.
MitoTEMPO targets mitochondrial superoxide (O2•−) but showed no protective effect on chronic hypoxia–induced pulmonary hypertension. Pulmonary artery remodeling and right ventricular remodeling developed despite treatment. Abstract Mitochondrial reactive oxygen species (mtROS) have been implicated in the development of chronic hypoxia‐induced pulmonary
Esraa M. Zeidan, Sai Aparna Nagarajan, Akylbek Sydykov, Jens Bier, Monika Brosien, Ashraf Taye, Oleg Pak, Hossein A. Ghofrani, Ralph Theo Schermuly, Werner Seeger, Norbert Weissmann, Natascha Sommer, Claudio Nardiello   +12 more
wiley   +1 more source

Predictive, Data‐Driven Design of Red‐Light Photoredox Catalysts for C─Heteroatom Bond Formation

Angewandte Chemie, Volume 138, Issue 9, 23 February 2026.
From redox numbers to red light: Donor oxidation and core reduction potentials predict E0‐0 in cyanoarene dyes, guiding selection of an efficient red‐light catalyst, 4MeODPATPN (PC13). Under 620 nm light, PC13 facilitates Ni‐catalyzed C─heteroatom cross‐couplings (C─N, C─O, C─S) with high functional‐group tolerance and reduced hydrodehalogenation ...
Amir Gizatullin, Tingting Yuan, Sascha Grotjahn, Luigi Cavallo, Burkhard König, Chen Zhu, Magnus Rueping   +6 more
wiley   +2 more sources

A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova, Thomas M. Geiger, Lorenzo Cianni, Dominika E. Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D. Hartmann, Jan Krönke, Izidor Sosič, Radosław P. Nowak, Michael Gütschow, Christian Steinebach   +15 more
wiley   +1 more source

Development of a SIN1 targeting inhibitor as a novel therapeutic approach for the treatment of malignancies. [PDF]

Mol Cancer Ther
Beauchamp EM, Jain A, Clutter M, Nahotko D, Lopez Fajardo E, Vagadia PP, Dunne SF, Mina A, Fischietti M, Oku CV, Blyth GT, Mishra RK, Karras E, Radecki SG, Lantz C, Addepalli S, Modi M, Zou L, Cho BK, Goo YA, Rossoff J, Fish EN, Saleiro D, Schiltz GE, Platanias LC.   +24 more
europepmc   +1 more source

Photothermal Conversion Promotes Challenging SNAr for Facile C─N Bond Formation

Angewandte Chemie, Volume 138, Issue 9, 23 February 2026.
Photothermal conversion enables facile aromatic C─N bond formation via red light irradiation. A variety of inter‐ and intramolecular SNAr transformations are achieved under mild, schematically simple conditions. Additionally, a thermally promoted halogen exchange mechanism provides access to aryl bromides, chlorides, and fluorides – making this ...
Megan E. Matter, Rory C. Devin, Erin E. Stache   +2 more
wiley   +1 more source

Novel Sulfonium Reagents for the Modular Synthesis of Spiro[2.3]Hexanes and Heteroatom-Containing Analogues: Synthesis, Application, and Evaluation as Bioisosteres. [PDF]

Angew Chem Int Ed Engl
Natho P, Vicenti A, Mastrolorito F, De Franco F, Walsh-Benn L, Colella M, Mesto E, Schingaro E, Nicolotti O, Gioiello A, Luisi R.   +10 more
europepmc   +1 more source

Computational Chemistry Advances in the Development of PARP1 Inhibitors for Breast Cancer Therapy. [PDF]

Pharmaceuticals (Basel)
Twala C, Govender P, Govender K.
europepmc   +1 more source

Allosteric targeting of RIPK1: discovery of novel inhibitors <i>via</i> parallel virtual screening and structure-guided optimization. [PDF]

RSC Med Chem
Vijayan RSK, Hamilton MM, Pfaffinger DE, Alvarez FG, Reyna NJ, Bardenhagen JP, Shepard H, Rodriguez C, Goodwani S, Lightfoot Y, Maskos K, Johannsson S, Kempf G, Xu QA, Neumann L, Jiang Y, Do MG, Jones P, Lewis RT, Ray WJ, Cross JB.   +20 more
europepmc   +1 more source