Results 201 to 210 of about 37,707 (289)

Synthesis and evaluation of isoquinolinyl and pyridinyl-based dual inhibitors of fatty acid amide hydrolase and soluble epoxide hydrolase to alleviate orofacial hyperalgesia in the rat. [PDF]

Biochem Biophys Rep
Carr D, Gunari S, Gorostiza G, Mercado M, Pavana L, Duong L, Gomez K, Salinas S, Garcia C, Tsang A, Morisseau C, Hammock BD, Pecic S, Kandasamy R.   +13 more
europepmc   +1 more source

Studies on Piperidine Derivatives. III. : Studies on the Synthesis of 3-Oxo-1-thia-4, 8-diazaspiro [4, 5] decane Derivatives. (1)

, 1971
Michio Nakanishi, KATSUO ARIMURA
openalex   +2 more sources

Upscaled Synthesis of α‐ and β‐Peptides in a Continuous‐Flow Reactor Using Propylene Carbonate as an Eco‐Friendly Solvent

Chemistry–Methods, EarlyView.
A rapid and scalable continuous‐flow solid‐phase peptide synthesis technology, using eco‐friendly propylene carbonate (PC) as a solvent is developed. Achieving high yields and purity, it synthesized α‐peptides, β‐peptide foldamers, and α/β‐peptide chimeras.
Nikolett Varró, Beáta Mándityné Huszka, Eszter Erdei, András Mándoki, István M. Mándity   +4 more
wiley   +1 more source

Computational metabolomics reveals overlooked chemodiversity of alkaloid scaffolds in Piper fimbriulatum. [PDF]

Plant J
Damiani T, Smith J, Hebra T, Perković M, Čičak M, Kadlecová A, Rybka V, Dračínský M, Pluskal T.   +8 more
europepmc   +1 more source

Determination of Diketopiperazine Formation During the Solid‐Phase Synthesis of C‐Terminal Acid Peptides

Chemistry–Methods, EarlyView.
Diketopiperazine formation (DKP) is one of the most serious side reactions during peptide synthesis. An accurate method to determine the DKP formation in peptide synthesis on Wang resin is reported. Furthermore, the strategies to minimize this side reaction and side products lacking C‐terminal amino acids are described. Diketopiperazine formation (DKP)
Mani Kaushal, Ashish Kumar, Hassan Gamal, Sinenhlanhla N. Mthembu, Rotimi Sheyi, XiaoKang Kou, Beatriz G. de la Torre, Fernando Albericio   +7 more
wiley   +1 more source

Kinetic and Theoretical Studies of 3,5-Dicyanothiophene Reactivity with Cyclic Secondary Amines in Water and Acetonitrile: Quantification, Correlation, and Prediction. [PDF]

J Phys Chem A
Hamdi R, Ghabi A, Bouazizi S, Anouar L, Longevial JF, Sindt M, Ayachi S, Boubaker T.   +7 more
europepmc   +1 more source

Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with <i>MTAP</i> Deletion. [PDF]

J Med Chem
Cottrell KM, Briggs KJ, Tsai A, Tonini MR, Whittington DA, Gong S, Liang C, McCarren P, Zhang M, Zhang W, Huang A, Maxwell JP.   +11 more
europepmc   +1 more source

Open‐Chain Tetrapyrroles Meet Metal Ions in the Functional Molecular Material Science

ChemPlusChem, EarlyView.
Open‐chain tetrapyrroles, synthesized via oxidative cleavage and condensation, offer greater structural flexibility than cyclic counterparts like porphyrins. Their tunable electronic and geometric properties through metalation enable applications in bioimaging, therapies, ion sensing, chiroptical materials, and spintronic devices, making them valuable ...
Aninda Ghosh, Sandipa Bhandari, Hiroyuki Furuta, Masatoshi Ishida   +3 more
wiley   +1 more source

Novel sigma 1-antagonists with <i>cis</i>-(+)-normetazocine scaffold: synthesis, molecular modeling, and antinociceptive effect. [PDF]

RSC Med Chem
Costanzo G, Cosentino G, Grasso M, Patamia V, Zuccalà S, Coco A, Novello E, Al-Khrasani M, Morrone R, Pitari GM, Amata E, Marrazzo A, Rescifina A, Pasquinucci L, Parenti C.   +14 more
europepmc   +1 more source

Scope and Limitations of the Use of Methanesulfonic Acid (MSA) as a Green Acid for Global Deprotection in Solid‐Phase Peptide Synthesis

ChemSusChem, EarlyView.
TFA is the only acid used for the cleavage of peptides from the resin. However, this acid belongs to the PFAS family, which is anticipated to face usage restrictions. Herein, the use of MSA, which is a “Natural Green Acid” is proposed to substitute TFA for the global deprotection and cleavage in SPPS.
Giovanni Vivenzio, Sikabwe Noki, Amit Chakraborty, John Lopez, Beatriz G de la Torre, Fernando Albericio   +5 more
wiley   +1 more source