Results 281 to 290 of about 24,581 (324)

Driving tert-butyl axial: the surprising cyclopropyl effect. [PDF]

Chem Sci
Izzotti AR, Gleason JL.
europepmc   +1 more source

Simultaneous Grafting of 3,4,5‐Trihydroxypiperidine Iminosugars Onto Multivalent Scaffolds via Double Reductive Amination Provides New GCase Inhibitors

Chemistry – A European Journal, Volume 32, Issue 2, 9 January 2026.
A small set of low‐valency multivalent 3,4,5‐trihydroxypiperidines was prepared through double reductive amination (DRA) of a sugar‐derived dialdehyde. Among them, trivalent derivative 37 emerged as a potent β‐glucocerebrosidase (GCase) inhibitor displaying an unexpected mixed‐type kinetic profile. The integration of kinetic analysis, NMR, docking, and
Maria Giulia Davighi, Francesca Clemente, Alessio Morano, Francesca Mangiavacchi, Francesca Cardona, Andrea Goti, Paolo Paoli, Amelia Morrone, Ferran Nieto‐Fabregat, Roberta Marchetti, Camilla Matassini   +10 more
wiley   +1 more source

Retraction: Robust, highly active, and stable supported Co(ii) nanoparticles on magnetic cellulose nanofiber-functionalized for the multi-component reactions of piperidines and alcohol oxidation. [PDF]

RSC Adv
Ghamari Kargar P, Bagherzade G.
europepmc   +1 more source

Regulierung der Promiskuitiven Katalyse durch Substratinduzierte Transiente Assemblierung

Angewandte Chemie, Volume 138, Issue 1, 2 January 2026.
Wir berichten über eine neuartige substratinduzierte transiente Koassemblierung zwischen einem kurzen lysinreichen Peptid und Fmoc‐Gly‐OH. Im aktivierten Zustand zeigt die Assemblierung eine promiskuitive katalytische Aktivität durch die Beschleunigung der Hydrolyse und der C═N‐Kondensationsreaktion.
Ayan Chatterjee, Maximilian Schuler, Marius G. Braun, Christopher V. Synatschke, Qi Lu, Jiyao Yu, David Y. W. Ng, Tanja Weil   +7 more
wiley   +1 more source

Genetische Codierung von Pentafluorphosphato‐Phenylalanin ermöglicht die Herstellung von PF5‐Proteinen als Phosphoprotein‐Mimetika

Angewandte Chemie, Volume 138, Issue 1, 2 January 2026.
Erweiterung des genetischen Codes mit einem einzigartigen hyperfluorierten Phosphotyrosin‐Analogon. In dieser Arbeit haben wir die nicht‐natürliche Aminosäure Pentafluorphosphato‐Difluormethyl‐Phenylalanin, die sieben Fluoratome und eine permanente negative Ladung trägt, mittels mutierter, orthogonaler Aminoacyl‐tRNA‐Synthetasen erfolgreich in drei ...
Anna Magdalena Ambros, Haocheng Qianzhu, Markus Tiemann, Edan Habel, Katrin Denzinger, Hana Zupan, Matteo Accorsi, Bettina G. Keller, Gerhard Wolber, Thomas Huber, Jörg Rademann   +10 more
wiley   +1 more source

Stereocontrolled and time-honored access to piperidine- and pyrrolidine-fused 3-methylenetetrahydropyrans using lactam-tethered alkenols. [PDF]

RSC Adv
Beng TK, Anosike IS, Kaur J.
europepmc   +1 more source

Efficacy and safety of tofacitinib treatment in Finnish patients with juvenile idiopathic arthritis: a real-life study. [PDF]

Arthritis Res Ther
Levälampi T, Rebane K, Mikola K, Kautiainen H, Aalto K.   +4 more
europepmc   +1 more source

Therapeutic comparison of MitoTEMPO and rosmarinic acid as mitochondria targeted and non targeted antioxidants evaluated in rat sciatic nerve crush injury model. [PDF]

Sci Rep
Akkoca A, Gültekin B, Şen A, Kutlu S.
europepmc   +1 more source

Oxidative Dearomatization of Pyridines. [PDF]

J Am Chem Soc
Siddiqi Z, Bingham TW, Shimakawa T, Hesp KD, Shavnya A, Sarlah D.   +5 more
europepmc   +1 more source

The New Frontier of JAK Inhibitors: Significant Therapeutic Response to Tofacitinib in a Patient With Granulomatous Reaction to Filler in the Buttocks. [PDF]

J Cosmet Dermatol
Mansouri P, Farshi S.
europepmc   +1 more source