Results 291 to 300 of about 47,089 (385)

A Novel Reductive Amino Cyclization Method and Its Application for the Syntheses of Pyrrolidine and Piperidine Nucleus

, 1986
Masanori Somei, Fumio Yamada, Toshifumi Hasegawa, Masayuki Wakita, Mitsuru Sugiyama   +4 more
openalex   +1 more source

From beginning to end: the synecology of tree‐killing bark beetles, fungi, and trees

Biological Reviews, EarlyView.
ABSTRACT Over a century of research has revealed an amazing complexity of behaviours and physiological adaptations that allow tiny bark beetles to overcome large trees, sometimes resulting in outbreaks that kill millions of trees. Turning a tree into a home and successfully raising offspring involves constant interactions among the beetles, the tree ...
Diana L. Six, Almuth Hammerbacher, Amy Trowbridge, Lorinda Bullington   +3 more
wiley   +1 more source

Vitiligo: Ruxolitinib and Other Oral Treatment Options Beyond Ruxolitinib. [PDF]

Skin Res Technol
Ghani H, Tan IJ, Ghofrani S, Tchack M, Rao B.   +4 more
europepmc   +1 more source

Synthesis of piperidine derivatives with a quinazoline ring system as potential antihypertensive agents.

, 1986
Haruki Takai, H. OBASE, M. TERANISHI, Akira Karasawa, Kazuhiro Kubo, Katsuichi Shuto, Yutaka Kasuya, Koki Shigenobu   +7 more
openalex   +2 more sources

Behavioural Effects and Naloxone Effectiveness With New Synthetic Opioids

Drug and Alcohol Review, EarlyView.
ABSTRACT Introduction The global drug market has seen an emergence of potent synthetic opioids, including benzimidazole‐derived substances known as nitazenes. These compounds have been implicated in fatal and non‐fatal overdoses. This review aims to synthesise current evidence on the pharmacological effects, potency and naloxone responsiveness of new ...
Suzanne Nielsen, João Pedro Silva, Jermaine D. Jones, Alex Krotulski, Dilkushi Poovendran, Deusdedit Muzangizi, Gilles Forte, Jason White, Sandra D. Comer   +8 more
wiley   +1 more source

Dual Opioid-Neuropeptide FF Small Molecule Ligands Demonstrate Analgesia with Reduced Tolerance Liabilities. [PDF]

Molecules
Mottinelli M, Journigan VB, Obeng S, Pallares VLC, Mѐsangeau C, Kapanda CN, Cutler SJ, Lambert JA, Eans SO, Ganno ML, Sheng W, King T, Sharma A, Mollereau C, Avery BA, McLaughlin JP, McCurdy CR.   +16 more
europepmc   +1 more source

Molecular basis of domain‐specific angiotensin I‐converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat

The FEBS Journal, EarlyView.
Inhibition of angiotensin I‐converting enzyme is an effective strategy for the treatment of hypertension. However, the clinically available ACE inhibitors cause side effects due to nonselective inhibition of the two catalytic domains of ACE (nACE and cACE).
Kyle S. Gregory, Vinasha Ramasamy, Edward D. Sturrock, K. Ravi Acharya   +3 more
wiley   +1 more source

The New Frontier of JAK Inhibitors: Significant Therapeutic Response to Tofacitinib in a Patient With Granulomatous Reaction to Filler in the Buttocks. [PDF]

J Cosmet Dermatol
Mansouri P, Farshi S.
europepmc   +1 more source

Synthetic trap‐peptides identify a TOM complex phosphatase – PP2A dephosphorylates Tom6

The FEBS Journal, EarlyView.
Synthetic trap‐peptides facilitate the identification of complete holoenzymes that bind to the target sequence remarkably close to the phosphorylation site. PP4 bound to, but did not dephosphorylate, the peptide substrate taken from yeast Tom6 pSer16, showing that proximity alone does not induce phosphatase activity.
Laura Scheinost, Christina Ludwig, Nico Höfflin, Asli Aras Taskin, Adinarayana Marada, F.‐Nora Vögtle, Chris Meisinger, Maja Köhn   +7 more
wiley   +1 more source

Oxidative Dearomatization of Pyridines. [PDF]

J Am Chem Soc
Siddiqi Z, Bingham TW, Shimakawa T, Hesp KD, Shavnya A, Sarlah D.   +5 more
europepmc   +1 more source