Results 101 to 110 of about 2,988 (212)

Effect of pirenzepine on the N-demethylation of D(-)ephedrine and ethylmorphine by rabbit liver microsomes.

open access: yes, 1993
The possible interaction of pirenzepine with the mixed-function oxidases obtained from phenobarbital-pretreated rabbit microsomes was examined in vitro.
al-Khamees HA   +3 more
core  

Autonomic modulation during acute myocardial ischemia by low-dose pirenzepine in conscious dogs with a healed myocardial infarction: a comparison with beta-adrenergic blockade. [PDF]

open access: yes, 2003
Experimental and clinical evidence documents the ben- eficial effects of blocking sympathetic activity and modulating heart rate to reduce risk for lethal events in ischemic heart disease.
Pedretti RF   +4 more
core  

Effects of pirenzepine on plasma insulin, glucagon and pancreatic polypeptide levels in normal man.

open access: yes, 1985
The secretion of various pancreatic hormones (insulin, glucagon and pancreatic polypeptide) is affected to a different extent by the cholinergic system.
VALENTINI P.   +6 more
core   +1 more source

COMPARISON OF THE BRONCHODILATOR EFFICACY OF NEBULIZED PIRENZEPINE AND IPRATOPIUM BROMIDE IN PATIENTS WITH AIRWAY OBSTRUCTIVE LUNG-DISEASE

open access: yes, 1993
Ipratropium bromide (IB) is a non-selective muscarinic antagonist, whose bronchodilator efficacy has been shown in reversible and irreversible obstructive airway diseases.

core  

Effects of two new pirenzepine analogs on the contractile response of the guinea-pig oesophageal muscularis mucosae to acetylcholine, bethanechol, histamine and high potassium

open access: yes, 1990
The guinea-pig oesophageal muscularis mucosae was used to determine the affinity for muscarinic receptors of two new tricyclic compounds, DF 545 and DF 594, which are structurally related to pirenzepine.
BAROCELLI, Elisabetta   +4 more
core   +1 more source

Experimental antiulcer agents: N-substituted 2-(4-methyl-1-piperazinyl)acetamides as pirenzepine models and some related compounds

open access: yes, 1988
Reactions of N-cyclohexyl-2-chloroacetamide, N-phenyl-2-chloroacetamide, N-(4-dimethylaminophenyl)-2-chloroacetamide, N-(2-nitrophenyl)-N-phenyl-2-chloroacetamide, its 3-nitrophenyl and 4-nitrophenyl analogues, N-(2-benzylphenyl)-2-chloroacetamide, 5 ...
Zdeněk Polívka   +9 more
core   +1 more source

DEVELOPMENT AND IN VIVO EVALUATION OF MUCOADHESIVE MICROSPHERES USING PIRENZEPINE

open access: yes, 2018
Objective: The current investigation objective was to fabricate gastroretentive mucoadhesive microspheres of pirenzepine and to investigate the pharmacokinetic parameters of optimized formulation in comparison with a marketed product.Methods: Pirenzepine
P, Kanteepan, Dvrn, Bhikshapathi
core  

80% of muscarinic receptors expressed by the NB-OK 1 human neuroblastoma cell line show high affinity for pirenzepine and are comparable to rat hippocampus M1 receptors.

open access: yes, 1988
The NB-OK 1 human neuroblastoma cell line expressed muscarinic cholinergic receptors that could be labeled with N-[3H]methylscopolamine (a nonselective antagonist). 80% of these receptors showed high affinity for pirenzepine, i.e.
Christophe, Jean   +8 more
core   +1 more source

Fluorescent Pirenzepine Derivatives as Potential Bitopic Ligands of the Human M1 Muscarinic Receptor

open access: yes, 2016
Following a recent description of fluorescence resonance energy transfer between enhanced green fluorescent protein (EGFP)-fused human muscarinic M1 receptors and Bodipy-labeled pirenzepine, we synthesized seven fluorescent derivatives of this antagonist
Isabelle Parrot (2295199)   +6 more
core   +1 more source

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