Results 191 to 200 of about 5,284 (226)

Pirenzepine versus Cimetidine in Duodenal Ulcer

Digestion, 1982
90 patients with active duodenal ulcer were admitted to a double-blind trial to compare the effects of pirenzepine (150 mg/daily), cimetidine (1 g/daily) and placebo on the healing of duodenal ulcer.
S. Daniotti, P.R. Dal Monte, Bianchi Porro, D'Imperio N, G Giuliani Piccari, M. Petrillo   +5 more
openaire   +2 more sources

Selectivity of pirenzepine in the central nervous system. I. Direct autoradiographic comparison of the regional distribution of pirenzepine and carbamylcholine binding sites

Brain Research, 1987
The binding capacities of the novel antagonist pirenzepine and the agonist carbamylcholine were examined autoradiographically to compare their abilities to reduce the binding of 1-[3H]quinuclidinyl benzilate ([3H]-1-QNB). This technique, which is applicable to any muscarinic ligand, permits a direct comparison between the binding of carbamylcholine and
William S. Messer, Wayne Hoss
openaire   +3 more sources

Effects of atropine and pirenzepine on sphincter of oddi motility

Journal of Hepatology, 1986
We studied the Oddi sphincter motility by endoscopic manometry in 10 consecutive patients randomized in a double-blind fashion, after i.v. administration of two anticholinergic compounds (0.5 mg atropine sulfate and 10 mg pirenzepine). Pirenzepine significantly decreased the basal sphincteric pressure, as well as the amplitude and frequency of the ...
Virginia Pertejo, Vicente Garrigues, Joaquín Berenguer, Julio Ponce, Teresa Sala   +4 more
openaire   +3 more sources

Effects of pirenzepine on vonoprazan-induced gastric acid inhibition and hypergastrinemia

European Journal of Clinical Pharmacology, 2021
Takahiro Suzuki, Tomohiro Higuchi, Takuma Kagami, T. Uotani, M. Yamade, Shinya Tani, Yasushi Hamaya, M. Iwaizumi, S. Osawa, K. Sugimoto, H. Miyajima, T. Furuta   +11 more
semanticscholar   +1 more source

Effect of the lipid environment on the differential affinity of purified cerebral and atrial muscarinic acetylcholine receptors for pirenzepine.

Molecular Pharmacology, 1989
Muscarinic acetylcholine receptors (mAChRs) of porcine cerebral membrane (predominantly M1 subtype) and porcine atrial membrane (M2 subtype) showed the same affinity for the muscarinic antagonist [3H]quinuclidinylbenzylate [( 3H]QNB).
Gabriel Berstein, Tatsuya Haga, Arata Ichiyama   +2 more
semanticscholar   +1 more source

Tricyclic compounds as selective antimuscarinics. 1. Structural requirements for selectivity toward the muscarinic acetylcholine receptor in a series of pirenzepine and imipramine analogues.

Journal of Medicinal Chemistry, 1987
The M1-selective antiulcer drug pirenzepine (1) is a tricyclic compound with close resemblance to tricyclic psychotropic agents such as imipramine (2).
W. Eberlein, G. Trummlitz, W. Engel, G. Schmidt, H. Pelzer, N. Mayer   +5 more
semanticscholar   +1 more source

Low-dose antacids and pirenzepine in the treatment of patients with non-ulcer dyspepsia and erosive prepyloric changes. A randomized, double-blind, placebo-controlled trial.

Scandinavian Journal of Gastroenterology, 1988
One hundred consecutive patients with non-ulcer dyspepsia (NUD) and the endoscopic diagnosis of erosive prepyloric changes (EPC) were included in a 4-week double-blind, placebo-controlled trial.
R. Weberg, A. Berstad
semanticscholar   +1 more source

Comparison of telenzepine, pirenzepine and atropine on gastric acid and pepsin secretion in response to histamine, pentagastrin, bethanechol, sham-feeding and feeding.

Digestion, 1989
This study was designed to compare gastric antisecretory effects of telenzepine, a new antimuscarinic agent, with those of pirenzepine and atropine in dogs.
Stanislaw J. Konturek, J. Tasler, M. Cieszkowski, Krystyna Szewczyk, Wolfgang Kromer   +4 more
semanticscholar   +1 more source

Anticholinergic Effects of Pirenzepine on the Guinea-Pig Isolated Atrium

Pharmacology, 1979
In the guinea-pig isolated atrium pirenzepine shifts the concentration response curve of carbachol on frequency towards the right thus indicating that pirenzepine has anticholinergic properties.
K. Süsskand, K.-F. Sewing
openaire   +3 more sources

[Corneal permeability of topically applied pirenzepine solution].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 2006
To study the corneal permeability of three different pirenzepine eye-drop solutions and provide reference for further clinical use.Sixty-three New Zealand white rabbits were divided into three groups. Each group of rabbits received 2% pirenzepine (pirenzepine group), 2% pirenzepine with 0.1% hyaluronic acid (hyaluronic acid group), or 2% pirenzepine ...
Pan-shi Yan, Jin-song Zhang, Kai-di Wang
openaire   +3 more sources