Results 201 to 210 of about 5,030 (261)
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Pyrimidobenzodiazepines. Synthesis of pirenzepine analog.
Die Pharmazie, 1990The synthesis of Pyrimido[4,5-b][1,5]benzodiazepine derivatives from 4-(o-aminophenylene)amino-5-ethoxy-carbonyl-1,2-dihydro-6-methyl-2 - oxopyrimidine has been described. Pyrimidobenzodiazepine 5 alkylated with N-methyl-N'-chloroacetyl-piperazine gives a product related to pirenzepine. Compound 5 shows weak antianxiety and antidepressive action.
Długosz, Anna, Machoń, Zdzisław
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PLASMA AND BILIARY DISPOSITION OF PIRENZEPINE IN MAN
Clinical and Experimental Pharmacology and Physiology, 1986SUMMARY1. The binding of pirenzepine, a selective muscarinic receptor antagonist to plasma and bile, was studied in vitro and in vivo. Plasma and hepatic bile were incubated with 14C‐pirenzepine and the bound fraction of 14C‐pirenzepine determined by equilibrium dialysis. The bound fractions were 12.6% (s.e.m.
Lee, SP, Paxton, JW, Choong, YS
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Pirenzepine and Gastrointestinal Motility: Differential Effect of Pirenzepine in the Gut
1985The capacity of pirenzepine to reduce gastric acid secretion in the basal state and after various forms of stimulation is well established by now (Jaup 1981). It is still under discussion whether the ulcer-healing and symptom-relieving effect of pirenzepine is solely due to the moderate acid reduction observed or whether other pharmacological ...
R. W. Stockbrügger +3 more
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Central oxotremorine antagonist properties of pirenzepine
Life Sciences, 1988Pirenzepine, the prototype M1 muscarinic receptor antagonist, is an important compound for investigating the functional significance of M1 receptors at the integrated level of behavior but may have limitations imposed by its physical chemistry. Like the nonselective antagonist methylatropine, pirenzepine is highly hydrophilic and crosses the blood ...
J M, Witkin +3 more
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Modulation of gallbladder contraction by pirenzepine in man
Pharmacological Research, 1995The mechanism(s) by which cholinergic innervation modulates gallbladder contraction are not fully understood. To elucidate the role of muscarinic M1 receptors in the mediation of gallbladder contraction, we investigated gallbladder volume reduction, plasma cholecystokinin (CCK), and pancreatic polypeptide (PP) responses in humans during cephalic and ...
B, Yeğen +7 more
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The Effect of Pirenzepine on Gallbladder Emptying in Humans
The Journal of Clinical Pharmacology, 1986The effect of the selective antimuscarinic agent, pirenzepine, on gallbladder function was studied in six healthy volunteers, using 99mTc HIDA (N‐[2,6‐diethylthenyl] carbamoylmethyl iminodiacetic acid) hepatobiliary scanning. Pirenzepine, in doses that inhibit gastric acid secretion, did not alter gallbladder emptying responses to sham feeding ...
A, Keshavarzian +3 more
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The pharmacokinetic profile of pirenzepine.
Scandinavian journal of gastroenterology. Supplement, 1980This paper gives a brief review of the pharmacokinetic studies performed on pirenzepine (L S 519 Cl2, Gastrozepin hitherto. Particular attention will be paid thereby to the clinical significance of the pharmacokinetic parameters.
R, Hammer, F W, Koss
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Central action of pirenzepine.
Polish journal of pharmacology and pharmacy, 1982Pirenzepine, (5,11-dihydro-11-[(4-methylpiperazin-1-yl)-acetyl]-6H-pyrido-[2,3] [1,4]-benzodiazepin-6-one dihydrochloride), tested on rats and mice, did not demonstrate any conspicuous behavioral action: it did not counteract reserpine hypothermia in mice, the L-DOPA hypermotility of mice, and (with the exception of very large doses) the amphetamine ...
Z, Rogóz, G, Skuza, H, Sowińska
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Psychometric studies of pirenzepine.
Scandinavian journal of gastroenterology. Supplement, 1981A single dose of 10 mg of pirenzepine given i.m. to 7 healthy volunteers did not elicit local or general signs of intolerance within 6 hours after injection. We also found no significant differences in tests of vegetative symptomatology, visual motor coordination, attention concentration, critical flicker test threshold, nor any other aspects of the ...
E, Kuhn, R, Honzák
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What are the indications of pirenzepine?
1989At the parietal gastric cells where hydrochloric acid is secreted there are cholinergic receptors, particularly muscarinic receptors. Pirenzepine is a pyridobenzodiazepine which blocks the Ml muscarinic receptors of the gastric wall exerting a selective anti- muscarinic action.
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