Results 111 to 120 of about 596,846 (253)

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

Genetic visualization of the secondary olfactory pathway in Tbx21 transgenic mice [PDF]

, 2011
Background Mitral and tufted cells are the projection neurons in the olfactory bulb, conveying odour information to various regions of the olfactory cortex.
Sachiko Mitsui, Kei M Igarashi, Kensaku Mori, Yoshihiro Yoshihara   +3 more
core   +1 more source

The Microbiota Shapes Central Nervous System Myelination in Early Life

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch, Emily G. Knox, Daniel Soong, Thomaz F. S. Bastiaanssen, Kalevi Trontti, Gabriel S. S. Tofani, Sophia Ivaschuk, Michael K. Collins, Donia Arafa, Jatin Nagpal, Iiris Hovatta, David A. Lyons, Gerard Clarke, John F. Cryan   +13 more
wiley   +1 more source

In the Piriform Cortex, the Primary Impetus for Information Encoding through Synaptic Plasticity Is Provided by Descending Rather than Ascending Olfactory Inputs

Cerebral Cortex, 2018
Information encoding by means of persistent changes in synaptic strength supports long-term information storage and memory in structures such as the hippocampus.
Christina Strauch, D. Manahan‐Vaughan
semanticscholar   +1 more source

Cell-Type-Specific Whole-Brain Direct Inputs to the Anterior and Posterior Piriform Cortex

Frontiers in Neural Circuits, 2020
The piriform cortex (PC) is a key brain area involved in both processing and coding of olfactory information. It is implicated in various brain disorders, such as epilepsy, Alzheimer’s disease, and autism.
Li Wang, Li Wang, Zhijian Zhang, Jiacheng Chen, Anne Manyande, Rafi Haddad, Qing Liu, Qing Liu, Fuqiang Xu, Fuqiang Xu, Fuqiang Xu, Fuqiang Xu, Fuqiang Xu   +12 more
doaj   +1 more source

International Veterinary Epilepsy Task Force recommendations for systematic sampling and processing of brains from epileptic dogs and cats [PDF]

, 2015
Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities.
A Jeans, A Katelaris, A Klang, A Pakozdy, A Pakozdy, A Pitkanen, A Woznicka, Akos Pakozdy, AM Wahle, Andrea Fischer, Andrea Tipold, Clare Rusbridge, DM Kowalska, Edward E. Patterson, ES Park, Eva Wagner, F Reinoso-Suárez, Francisco Fernández-Flores, G Isoardo, H Potschka, H Urbach, Heidrun Potschka, HO Lüders, Holger A. Volk, I Blumcke, I Toyoda, IK Hwang, J O’Muircheartaigh, Jacques Penderis, JE Cavazos, JH Margerison, JN Kornegay, JY Cheong, K Baiker, K Kobow, Karen Muñana, Kaspar Matiasek, L Wang, LP Hudson, Luisa De Risio, M Fischer, M Manford, M Oehmichen, M Sasaki, M Singer, M Thom, M Thom, M Wolf, Marco Rosati, Martí Pumarola i Batlle, ME Milne, Mette Berendt, Michael Podell, MP Witter, N Shihab, PS Buckmaster, R Adamec, R Crooks, RE Adamec, RE Adamec, RM Packer, RN Auer, Robyn G. Farquhar, S Lomoio, S Schriefl, Sam Long, Simon Platt, Sofie F. M. Bhatti, SY Bando, T Kuwabara, TS Jokinen, U Seneviratne, VA Gil, Veronika M. Stein, Y Masuo, Z Ahmed   +75 more
core   +7 more sources

Sex and life experience shape locus coeruleus pretangle tau pathology

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Alzheimer's disease features early a pathology in the locus coeruleus (LC), yet how sex and life experience shape LC vulnerability remains poorly understood. METHODS We expressed pseudophosphorylated human tau (htauE14) in LC neurons of TH‐Cre rats and exposed both sexes to early‐ or late‐life enrichment or stress.
Zia Hasan, Sarah E. Torraville, Tamunotonye Omoluabi, Aida Maziar, Onyedikachi N. Belolise, Lauren A. MacGowan, Cassandra M. Flynn, Camila Reinhardt, Susan G. Walling, Touati Benoukraf, Qi Yuan   +10 more
wiley   +1 more source

Differential inhibition of pyramidal cells and inhibitory interneurons along the rostrocaudal axis of anterior piriform cortex

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance In most primary sensory cortical areas, sensory information is topographically organized. The spatial mapping of sensory features has proven useful in elucidating circuit mechanisms that underlie sensory representations in the brain.
Adam M. Large, N. Vogler, Martha Canto-Bustos, F. Kathryn Friason, Paul Schick, Anne-Marie M. Oswald   +5 more
semanticscholar   +1 more source

Anatomical Progression of Neuropathology in FTLD‐TDP Type C and Linkage to Annexin A11

Annals of Neurology, Volume 99, Issue 3, Page 639-655, March 2026.
Objective Frontotemporal lobar degenerations (FTLD)‐TDP type C (TDP‐C) is distinguished from other FTLD‐TDP subtypes by 3 unique features: (1) invariable onset in the anterior temporal lobe (ATL), (2) phosphorylated TDP‐43 (pTDP) neurites in cortex, and (3) colocalization of all pTDP deposits with annexin A11 (ANXA11).
Allegra Kawles, Caroline Nelson, Ivan Ayala, Elena Barbieri, Rudolph Castellani, Changiz Geula, Tamar Gefen, M. Marsel Mesulam   +7 more
wiley   +1 more source

Learning to smell danger: Acquired associative representation of threat in the olfactory cortex

Frontiers in Behavioral Neuroscience, 2014
Neuroscience research over the past few decades has reached a strong consensus that the amygdala plays a key role in emotion processing. However, many questions remain unanswered, especially concerning emotion perception.
Wen eLi, Wen eLi
doaj   +1 more source