Results 61 to 70 of about 17,674 (187)

A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova, Thomas M. Geiger, Lorenzo Cianni, Dominika E. Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D. Hartmann, Jan Krönke, Izidor Sosič, Radosław P. Nowak, Michael Gütschow, Christian Steinebach   +15 more
wiley   +1 more source

Toxico-Neurological Effects of Piroxicam in Monogastric Animals

Journal of Experimental Neuroscience, 2016
Piroxicam is a benzothiazine compound with anti-inflammatory, antipyretic, and analgesic properties. Because of the very high efficacy of piroxicam and its increasing use in the treatment of carcinomas in dogs and cats, there is a need for acute toxicity
Saganuwan Alhaji Saganuwan, Orinya Agbaji Orinya   +1 more
doaj   +1 more source

Analgesic Management of Pain in Elite Athletes: A Systematic Review [PDF]

, 2018
Objective: To identify the prevalence, frequency of use, and effects of analgesic pain management strategies used in elite athletes. Design: Systematic literature review.
Danielson, Elizabeth C., Derman, Wayne, Dvorak, Jiri, Hainline, Brian, Harle, Christopher A., Smith, Lisa, Stuart, Mark   +6 more
core   +1 more source

Economic Burden of Sickle Cell Disease: A Retrospective Study of Pediatric and Adult Individuals With Medicaid Coverage From 2016 to 2020

American Journal of Hematology, Volume 101, Issue 2, Page 269-280, February 2026.
ABSTRACT There is limited information regarding the contemporary real‐world clinical and financial burden of Medicaid enrollees with sickle cell disease (SCD) in the United States. Using the IBM MarketScan Medicaid database (7/2016–12/2020), individuals with ≥ 3 SCD diagnoses were matched 1:1 on age, gender, and race to individuals without SCD ...
Giovanna Tedesco Barcelos, Telma Peixoto, Jose Alvir, Jay Lin, Christine L. Baker   +4 more
wiley   +1 more source

Synthesis and electrochemical properties of environmental free l-glutathione grafted graphene oxide/ZnO nanocomposite for highly selective piroxicam sensing

Journal of Pharmaceutical Analysis, 2021
A simple and reliable strategy was proposed to engineer the glutathione grafted graphene oxide/ZnO nanocomposite (glutathione-GO/ZnO) as electrode material for the high-performance piroxicam sensor.
N. Dhanalakshmi, T. Priya, S. Thennarasu, S. Sivanesan, N. Thinakaran   +4 more
doaj   +1 more source

Use of gastroprotective agents in recommended doses in hospitalized patients receiving NSAIDs: a drug utilization study [PDF]

, 2006
OBJECTIVE: In recent years, studies investigated to what extend recommendations for co-prescribing gastroprotective agents in prevention of NSAID-induced gastrointestinal complications are followed in clinical practice.
Bilušić, Marinko, Erdeljić, Viktorija, Francetić, Igor, Huić, Mirjana, Macolić Šarinić, Viola, Makar-Aušperger, Ksenija, Merčep, Iveta   +6 more
core   +1 more source

Anti‐Arthritic Potential of Pyrazoline Derivative Against Complete Freund's Adjuvant Induced Arthritis in Rats

Journal of Cellular and Molecular Medicine, Volume 30, Issue 4, February 2026.
ABSTRACT This research explored the potential of a synthesised pyrazoline derivative 5‐ethoxy 5‐hydroxy 3‐methyls 4, 5‐dihydro 1Hpyrazol 1 yl (pyridine 4 yl) methanone [5‐E‐5‐H‐PD], against arthritis using a Complete Freund's Adjuvant (CFA)‐induced arthritis in a rat model.
Jian Li, Irfan Anjum, Halima Qadir, Faiza Naseer, Mehreen Arif, Muhammad Riaz, Rabia Gul, Madiha Kanwal, Bei Zhuang   +8 more
wiley   +1 more source

Fotossensibilidade induzida pelo piroxicam.

Acta Médica Portuguesa, 1998
In Portugal, piroxicam is one of the most prescribed non-steroidal anti-inflammatory agents (NSAIDs) and is frequently associated to photosensitivity skin reactions, well known by all dermatologists.
P Varela, I Amorim, M Sanches, A Massa, E Santos   +4 more
doaj   +1 more source

Phosphorylation of silk fibroins improves the cytocompatibility of silk fibroin derived materials: a platform for the production of tuneable material [PDF]

, 2014
Silk fibroin demonstrates great biocompatibility and is suitable for many biomedical applications, including tissue engineering and regenerative medicine.
Adams, Ann H. Cory, Bramson, Bruylants, Budhavaram, Chiao, Costa, D'Angelo, Dawson, Freddi, Fuller, Ganguly, Geladopoulos, Ha, Hezi-Yamit, Higuchi, Hofmann, Hu, Huang, Kamlesh, Kaplan, Karageorgiou, Khorasani, Khorasani, Kiremitçi, Kong, Kreegipuu, Li, Liu, Liu, Magoshi, Magoshi, Mai-ngam, Mandell, Mann, Mieszawska, Mo, Modhave, Motomizu, Motta, N. V. Bhat, Numata, Numata, O'Toole, Philip, Polyansky, Poskus, Potoyan, Richards, Rothstein, Shang, Shen, Silva, Silva, Skehan, Smiechowski, Tabata, Takács-Novák1, Tanaka, Tsukada, Vepari, Wang, Wang, Westheimer, Winkler, Winkler, Wong Po Foo, Xue, Xue, Yang, Zhou   +70 more
core   +1 more source

Comparative Evaluation of Topical Stabilized Retinaldehyde 0.1% vs. 0.05% on Skin Biophysical and Biomechanical Parameters

Skin Research and Technology, Volume 32, Issue 2, February 2026.
ABSTRACT Background The aim of this study was to evaluate the biophysical and biomechanical effects of topical stabilized retinaldehyde (RAL) treatments on skin, using different concentrations of retinal (0.05% and 0.1%). Materials and Methods Employing a split‐face design and noninvasive methods such as high‐frequency ultrasonography, the Antera 3D ...
Anna Deda, Wiktoria Odrzywołek, Agata Lebiedowska, Anna Banyś, Małgorzata Bożek, Dagmara Kuca, Nina Wiśniewska, Dominika Wcisło‐Dziadecka, Sławomir Wilczyński   +8 more
wiley   +1 more source