Results 41 to 50 of about 6,072 (168)

Formulation and Characterization of Piroxicam as Self-Nano Emulsifying Drug Delivery System

Iraqi Journal of Pharmaceutical Sciences, 2020
Piroxicam (PIR) is a nonsteroidal anti-inflammatory drug of oxicam category, used in gout, arthritis, as well as other inflammatory conditions (topically and orally).
Fahad F. Salim, Nawal A. Rajab
doaj   +1 more source

What Do We Know About Cyclooxygenases Expression in the Lower Urinary Tract of Dogs and Cats? A Systematic Review

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Cyclooxygenases (COX‐1 and COX‐2) are key enzymes in the biosynthesis of prostanoids, which mediate physiological functions, inflammation, and the process of carcinogenesis. In dogs and cats, lower urinary tract diseases are prevalent and often complex, requiring targeted therapeutic interventions.
Reiner Silveira de Moraes, Luíz Guilherme Dércore Benevenuto, Ana Giulia Gabriel da Rocha Cesario, Julia Franco Ferreira, Suellen Rodrigues Maia, Doughlas Regalin, Dirceu Guilherme de Souza Ramos, Alessandra Melchert, Priscylla Tatiana Chalfun Guimarães‐Okamoto   +8 more
wiley   +1 more source

Cytoprotective and enhanced anti-inflammatory activities of liposomal piroxicam formulation in lipopolysaccharide-stimulated RAW 264.7 macrophages

International Journal of Nanomedicine, 2013
Hoe Siong Chiong,1 Yoke Keong Yong,1 Zuraini Ahmad,1 Mohd Roslan Sulaiman,1 Zainul Amiruddin Zakaria,1 Kah Hay Yuen,2 Muhammad Nazrul Hakim1,31Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia; 2School of ...
Chiong HS, Yong YK, Ahmad Z, Sulaiman MR, Zakaria ZA, Yuen KH, Hakim MN   +6 more
doaj  

Codocytosis in the Dog: 345 Cases (2020–2022)

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Introduction Codocytes, or target cells, are a morphologic variation of erythrocytes characterized by increased membrane surface area relative to volume. In dogs, codocytosis is frequently noted on blood smear evaluation, but its clinical significance remains poorly understood. Objectives To characterize the clinical conditions associated with
Sarena M. Krojanker, Maria Jaramillo, Brad D. Cingolani, Floyd L. Williams Jr., Priscila B. S. Serpa, Andrew D. Woolcock   +5 more
wiley   +1 more source

Dermatological Adverse Events Associated With Lapatinib Treatment in Dogs With Urothelial Carcinoma: A Retrospective Study

Veterinary Dermatology, EarlyView.
Lapatinib is widely used in human oncology; however, dermatological adverse events (DAEs) are common and have been correlated with treatment efficacy. In veterinary medicine, lapatinib use in combination with piroxicam has been shown to be effective in treating canine urothelial carcinoma (UC); however, the incidence and prognostic significance of DAEs
Kosuke Horita, Tomohiro Yonezawa, Yasuyuki Momoi, Shingo Maeda   +3 more
wiley   +1 more source

TOPICAL OLEO-HYDROGEL PREPARATIONS OF PIROXICAM WITH ENHANCED SKIN PERMEABILITY AND ANTIINFLAMMATORY ACTIVITY

Zagazig Journal of Pharmaceutical Sciences, 2000
In an attempt to improve the skin permeation and anti-inflammatory activity of piroxicam, various topical formulations including oleo-hydrogels (oleo-gels) were prepared and their in vitro diffusion, skin permeation and in vivo anti-inflammatory ...
Fergany Mohammed , Nailia Boulatova
doaj   +1 more source

Retrospective Analysis of Survival and Adverse Effects Associated With Stereotactic Body Radiation Therapy in 12 Dogs With Hepatocellular Carcinoma

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 485-498, September 2026.
ABSTRACT This retrospective analysis evaluated 12 dogs with hepatocellular carcinoma (HCC) who received stereotactic body radiation therapy (SBRT). Dogs received between 6 and 25 Grey (Gy) per fraction for 1–5 fractions for a total dose of 13–30 Gy. Eleven patients (92%) experienced acute adverse effects (AE), with the majority being VRTOG grade 2–3 ...
Victoria Lee Newberry, Mary‐Keara Boss, Del Leary, Tiffany W. Martin   +3 more
wiley   +1 more source

Piroxicam accelerates diabetic foot ulcer healing via ERα-dependent mitochondrial protection and oxidative stress relief

Frontiers in Pharmacology
IntroductionThe pathology of diabetic foot ulcer (DFU) is characterized by keratinocyte dysfunction, non-resolving inflammation, and oxidative stress.
Qing-Qing Liao, Li-Ping Chen, Jia-Qi Zheng, Yu-Jie Yang, Jing-Dan Weng, Teng Xie, Xiao-Dong Sun, Xiao-Dong Sun, Yuan-Yuan Zhang, Yuan-Yuan Zhang   +9 more
doaj   +1 more source

Development and characterization of solid dispersion of piroxicam for improvement of dissolution rate using hydrophilic carriers [PDF]

BioImpacts, 2014
Introduction: The main objective of this study was preparation and characterization of solid dispersion of piroxicam to enhance its dissolution rate. Methods: Solid dispersion formulations with different carriers including crospovidone, microcrystalline ...
Mohammad Barzegar-jalali, Saeed Ghanbarzadeh, Khosro Adibkia, Hadi Valizadeh, Ghobad Mohammadi, Mohammadreza Siahi-Shadbad   +5 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Chiral Urea and Thiourea Derivatives as Multitarget‐Directed Anti‐Alzheimer Agents

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A series of novel chiral urea and thiourea compounds were designed as multitarget‐directed ligands for Alzheimer's disease and evaluated against hAChE, hBChE, and hMAO‐B, with exploratory assessment of HSD10. These chiral compounds were synthesized and fully characterized, and their enantiopurity was confirmed via HPLC.
Sule Erol Gunal, Senel Teke Tuncel, İlke Demir, İpek Baysal, Gökçen Telli, Safiye Sag Erdem, Gulberk Ucar, Michaela Hanzlova, Kamil Musilek, İlknur Dogan, Nesrin Gokhan Kelekci   +10 more
wiley   +1 more source