Results 51 to 60 of about 9,407 (166)

Development and characterization of solid dispersion of piroxicam for improvement of dissolution rate using hydrophilic carriers [PDF]

BioImpacts, 2014
Introduction: The main objective of this study was preparation and characterization of solid dispersion of piroxicam to enhance its dissolution rate. Methods: Solid dispersion formulations with different carriers including crospovidone, microcrystalline ...
Mohammad Barzegar-jalali, Saeed Ghanbarzadeh, Khosro Adibkia, Hadi Valizadeh, Ghobad Mohammadi, Mohammadreza Siahi-Shadbad   +5 more
doaj   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, Volume 13, Issue 52, 18 September 2026.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Stereoselective Construction of Benzo‐Fused Tetrahydropyrrole Thiazines From Saccharin

European Journal of Organic Chemistry, Volume 29, Issue 33, 1 September 2026.
Saccharin was used as a template to construct a series of 10a‐substituted, benzo‐fused, pyrrolo thiazinone dioxides. Thereafter, diastereo‐divergent 10‐keto reduction gave either diastereomeric alcohol in a process that did not rely on the substituent at 10a's identity.
Seanán Doyle, Matthew Kiernan, Jordan Smyth, Ajay Mathew, Conor J. Crawford, Julia Bruno‐Colmenarez, Patrick J. Guiry, Aisha Khalifa, Paul Evans   +8 more
wiley   +1 more source

Zinc-piroxicam: kinetics in blood and lymph

, 2011
Vários mecanismos foram propostos para reduzir a toxicidade gástrica dos fármacos antiinflamatórios. A complexação com zinco foi proposta considerando-se o fato de que o zinco possui ação protetora sobre a mucosa gástrica.
Toledo, Maria Inês de
core   +1 more source

Toxico-Neurological Effects of Piroxicam in Monogastric Animals

Journal of Experimental Neuroscience, 2016
Piroxicam is a benzothiazine compound with anti-inflammatory, antipyretic, and analgesic properties. Because of the very high efficacy of piroxicam and its increasing use in the treatment of carcinomas in dogs and cats, there is a need for acute toxicity
Saganuwan Alhaji Saganuwan, Orinya Agbaji Orinya   +1 more
doaj   +1 more source

Unraveling the Anti‐Arthritic Potential of Bioactive Compounds From Melaleuca alternifolia Oil: Integrated In Vivo, Molecular Docking, and Network Pharmacology Insights

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Melaleuca alternifolia oil demonstrated significant anti‐arthritic effects in CFA‐induced rats by reducing paw edema, PGE2 levels, and inflammatory biomarkers. It improved hematological and histopathological parameters, modulated cytokine expression, and showed promising phytochemical‐target interactions through GC–MS, network pharmacology, and ...
Sana Sabir, Aisha Mobashar, Hossam Kamli, Hafiza Mahnoor Baghdadi, Bushra Akhtar, Amir Ali, Sana Saleem, Khalid Hussain, Kiran Mashaal, Esmael M. Alyami, Mona Alsolami, Fakhreldeen Dabiellil, Pravin Badhe, Gehan M. Elossaily, Muhammad Shahab, Abdel‐Rhman Z. Gaafar   +15 more
wiley   +1 more source

What Do We Know About Cyclooxygenases Expression in the Lower Urinary Tract of Dogs and Cats? A Systematic Review

Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 5, Page 433-443, September 2026.
ABSTRACT Cyclooxygenases (COX‐1 and COX‐2) are key enzymes in the biosynthesis of prostanoids, which mediate physiological functions, inflammation, and the process of carcinogenesis. In dogs and cats, lower urinary tract diseases are prevalent and often complex, requiring targeted therapeutic interventions.
Reiner Silveira de Moraes, Luíz Guilherme Dércore Benevenuto, Ana Giulia Gabriel da Rocha Cesario, Julia Franco Ferreira, Suellen Rodrigues Maia, Doughlas Regalin, Dirceu Guilherme de Souza Ramos, Alessandra Melchert, Priscylla Tatiana Chalfun Guimarães‐Okamoto   +8 more
wiley   +1 more source

Retrospective Analysis of Survival and Adverse Effects Associated With Stereotactic Body Radiation Therapy in 12 Dogs With Hepatocellular Carcinoma

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 485-498, September 2026.
ABSTRACT This retrospective analysis evaluated 12 dogs with hepatocellular carcinoma (HCC) who received stereotactic body radiation therapy (SBRT). Dogs received between 6 and 25 Grey (Gy) per fraction for 1–5 fractions for a total dose of 13–30 Gy. Eleven patients (92%) experienced acute adverse effects (AE), with the majority being VRTOG grade 2–3 ...
Victoria Lee Newberry, Mary‐Keara Boss, Del Leary, Tiffany W. Martin   +3 more
wiley   +1 more source

Histological changes induced by Piroxicam on the hepatic and renal tissues of mice with and without administration of Peppermint oil

Current Issues in Pharmacy and Medical Sciences, 2022
Piroxicam is a popular anti-inflammatory drug that displays palliative and antipyretic activity. Peppermint oil is a common flavoring used in foods and drinks.
Al-Hamdany Muna, Al-Tai Faten, Ismail Hanaa K.   +2 more
doaj   +1 more source

Structural Modifications of Nonsteroidal Anti‐Inflammatory Drugs (NSAIDs): New Horizons in Antimicrobial Drug Discovery

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
This review provides a comprehensive analysis of the molecular modifications applied to NSAIDs to develop novel antimicrobial agents. By focusing on structural changes and their impact on biological activity, the study highlights innovative strategies to combat the global challenge of antimicrobial resistance.
Ebru Koçak Aslan, Ayşe Karagüzel, Miyase Gözde Gündüz   +2 more
wiley   +1 more source