Results 111 to 120 of about 98,987 (242)

Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications

Neuroprotection, EarlyView.
Circadian dysregulation contributes to Alzheimer's disease through sleep disruption, clock‐gene dysfunction, neuroinflammation, impaired proteostasis, and metabolic imbalance. These alterations promote cognitive decline and disease progression, while circadian biomarkers and chronotherapeutic interventions offer opportunities for precision diagnosis ...
Bivek Singh, Filippo Pigazzani, Roberto Manfredini   +2 more
wiley   +1 more source

Pituitary Gland Volume in Fibromyalgia Syndrome: A Case-Control Volumetric MRI Study. [PDF]

J Pain Res
Seber T, Uylar Seber T, Çiçek F, Ülkü Demir FG, Payas A, Uçar İ.   +5 more
europepmc   +1 more source

Hospitalization Utilization Metric After Major Oncologic Head and Neck Surgery With Microvascular Free Flap

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective The primary length of stay (PLOS) metric fails to capture added time, costs, and reduced patient quality of life (QOL) associated with readmissions. To address these limitations, we propose a novel metric, the hospitalization utilization metric (HUM), which integrates PLOS and readmission LOS (RLOS). Study Design Retrospective review
Nana‐Hawwa Abdul‐Rahman, Anthony Tang, Zainab Balogun, Alexandria Harris, Shaum Sridharan, Matthew E. Spector, Carl H. Snyderman   +6 more
wiley   +1 more source

Significant expression of prosaposin in the intermediate lobe of mouse pituitary gland. [PDF]

Cell Tissue Res
Fuyuki A, Higuchi M, Homma T, Kitamura K, Onouchi S, Saito S.   +5 more
europepmc   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, EarlyView.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

NIR autofluorescence allows for pituitary gland detection during surgery: evidence from microscopic studies and in vivo measurements. [PDF]

Biomed Opt Express
Alibaeva V, Korneva N, Grigoriev A, Starkov G, Budylin G, Yakimov B, Azizyan V, Lapshina A, Pachuashvili N, Troshina E, Mokrysheva N, Urusova L, Shirshin E.   +12 more
europepmc   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Effects of Zearalenone on the Kiss1/GPR54 System and Related Genes Expression in the Hypothalamus and Pituitary Gland of Weaned Gilts. [PDF]

Toxins (Basel)
Yuan Z, Zhou M, Luan Y, Kong L, Yang W, Jiang S.   +5 more
europepmc   +1 more source

Evidence map and gap analysis of metabolic change in pediatric growth hormone deficiency treated with growth hormone

Pediatric Investigation, EarlyView.
This evidence map of 63 studies (n = 6158) showed growth hormone therapy in children with growth hormone deficiency has neutral glucose effects, mixed lipid outcomes, potential benefits for bone mineral density, bone mineral content, and parathyroid hormone, but generally no impact on thyroid function, body composition, or body mass index.
Wei Wu, Ningyi Song, Yue Zhao, Caiqi Du, Yuning Zhao, You Wu, Xiaoping Luo   +6 more
wiley   +1 more source

Identification of Novel Interacting Proteins of FUZ and GPR161

PROTEOMICS, EarlyView.
ABSTRACT Protein–protein interactions are central to the dynamic regulation of signaling pathways and provide critical insight into the cellular mechanisms underlying human disease. Our previous study demonstrated biochemical and genetic interactions between FUZ and GPR161 in sonic hedgehog signaling during spinal neural tube development. In this study,
Gabriella Salazar, Anna Battenhouse, Andrew J. Kim, Sung‐Eun Kim   +3 more
wiley   +1 more source