Results 121 to 130 of about 148,769 (361)

Anatomically Consistent Segmentation of Organs at Risk in MRI with Convolutional Neural Networks [PDF]

arXiv, 2019
Planning of radiotherapy involves accurate segmentation of a large number of organs at risk, i.e. organs for which irradiation doses should be minimized to avoid important side effects of the therapy. We propose a deep learning method for segmentation of organs at risk inside the brain region, from Magnetic Resonance (MR) images.
arxiv  

Pharmacokinetics of betamethasone in pre‐eclampsia: An in vivo and ex vivo study

British Journal of Clinical Pharmacology, EarlyView.
Aims To enhance understanding of betamethasone and its metabolites' pharmacokinetics in pregnancy, specifically early‐onset pre‐eclampsia, through a population pharmacokinetic model. Additionally, to investigate the placental metabolism and transfer of betamethasone and its main metabolites.
Sam Schoenmakers, Letao Li, Anna C. M. Kluivers, Michelle Broekhuizen, Madhavi S. Harhangi, A. H. Jan Danser, Irwin Reiss, Karel Allegaert, Sjoerd A. A. van den Berg, Bertrand D. van Zelst, Ron H. N. van Schaik, Philip L. J. DeKoninck, Emma Ronde, Sebastiaan D. T. Sassen, Sinno H. P. Simons, Birgit C. P. Koch   +15 more
wiley   +1 more source

Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma. [PDF]

, 2015
Adamantinomatous craniopharyngiomas (ACPs) are the most common pituitary tumours in children. Although histologically benign, these are clinically aggressive tumours, difficult to manage and associated with poor quality of life for the patients.
Martinez-Barbera, JP
core   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Corrin Ring Modification in Peptide Drug Development – a Brief History of “Corrination”

ChemMedChem, EarlyView.
This review highlights the applications of vitamin B12 conjugation (“corrination”) to peptides in the field of peptide‐based therapeutics, focusing on improved physio‐chemical properties, targeted/localized drug delivery, and enhanced oral bioavailability.
Nancy Cham, Robert P. Doyle
wiley   +1 more source

The effect of dietary pioglitazone supplementation on milk yield, insulin sensitivity and GH–IGF‐I axis in Holstein dairy cows during the transition period

Veterinary Medicine and Science, Volume 9, Issue 1, Page 336-344, January 2023., 2023
The high‐yielding dairy cows suffer from insulin resistance during the periparturient period. Dietary supplementation of pioglitazone hydrochloride, an insulin‐resistance drug and synthetic agonist for PPRAγ, improved the insulin sensitivity index (RQICKI‐BHBA) in Holstein dairy cows during the transition period. Abstract Background High‐yielding dairy
Saeed Mirzaie, Ali Reza Yousefi, Reza Masoumi, Behnam Rostami, Hamid Amanlou   +4 more
wiley   +1 more source

Night‐Time Chronotherapy with Methylprednisolone Prevents an Acute Rejection in Pediatric Patients with Liver Transplantation: A Randomized Clinical Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Concept of methylprednisolone chronotherapy to prevent acute rejections. While endogenous cortisol secretion rises in the early morning, the number of lymphocytes in the blood is higher at night, thus exhibiting an antiphase pattern to cortisol secretion. Therefore, compared with the daytime, the infiltration of lymphocytes into immune‐reactive tissues
Kentaro Ushijima, Yukihiro Sanada, Shinya Otomo, Keiko Ogaki, Taiichi Wakiya, Noriki Okada, Yuta Hirata, Yasuharu Onishi, Yasunaru Sakuma, Yukiyo Wada, Akio Fujimura, Koichi Mizuta   +11 more
wiley   +1 more source

Markers for internal neoplasia in the horse

Veterinary Medicine and Science, Volume 9, Issue 1, Page 132-143, January 2023., 2023
The measurement of tumour markers in horses should be performed only in risk groups or in patients with suspicious clinical/laboratory findings (paraneoplastic syndromes). The results should be interpreted with caution as many factors (e.g., young age, pregnancy and inflammation) affect their concentration or activity.
Karolina Drozdzewska, Heidrun Gehlen
wiley   +1 more source

Methodology of high‐dimensional flow cytometry in monitoring immune microenvironment of pituitary neuroendocrine tumors

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Characterization of the tumor immune microenvironment (TIME) of pituitary neuroendocrine tumors (PitNETs) is crucial for understanding the behavior of different types of PitNETs and identification of possible causes of their aggressiveness, rapid growth, and resistance to therapy.
Marina Yu Loguinova, Valeria V. Mazeeva, Daria V. Lisina, Elena N. Zakharova, Alyona V. Sorokina, Lilya U. Dzhemileva, Andrei Yu Grigoriev, Alexandra S. Shutova, Ekaterina A. Pigarova, Larisa K. Dzeranova, Galina A. Melnichenko, Natalia G. Mokrysheva, Sergei A. Rumiantsev, Vladimir P. Chekhonin   +13 more
wiley   +1 more source

An automated and multi-parametric algorithm for objective analysis of meibography images [PDF]

arXiv, 2020
Meibography is a non-contact imaging technique used by ophthalmologists to assist in the evaluation and diagnosis of meibomian gland dysfunction (MGD). While artificial qualitative analysis of meibography images could lead to low repeatability and efficiency and multi-parametric analysis is demanding to offer more comprehensive information in ...
arxiv