Results 61 to 70 of about 241,755 (405)

Direct effects of catecholamines, thyrotropin-releasing hormone, and somatostatin on growth hormone and prolactin secretion from adenomatous and nonadenomatous human pituitary cells in culture.

Journal of Clinical Investigation, 1984
To determine the mechanism and the site of action of catecholamines as well as hormones including thyrotropin-releasing hormone (TRH)1 and somatostatin on pituitary hormone release in patients with acromegaly and in normal subjects, the effects of these ...
M. Ishibashi, T. Yamaji
semanticscholar   +1 more source

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation

Advanced Science, EarlyView.
Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim, Quan Pan, Zeyu Liu, Weiqi Ai, Hye Won Han, Sakhila K. Banu, Robert Y.L. Tsai, Gus A. Wright, Shaodong Guo, Yuxiang Sun   +9 more
wiley   +1 more source

PACAP induces FSHβ gene expression via EPAC. [PDF]

, 2019
Gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are heterodimers of a common α subunit and unique β subunits. Regulation of their levels, primarily by GnRH, is critical for reproductive function.
Coss, Djurdjica, Yeh, Debra M
core  

Impact of Ghrelin‐Depleting Gastrectomy on Long‐Term Endocrine and Metabolic Health With a Focus on Skeletal Muscle and Bone Mineral Content

Annals of Gastroenterological Surgery, EarlyView.
This study investigates the long‐term endocrine and metabolic consequences of ghrelin‐depleted gastrectomy, with a focus on skeletal muscle mass and bone mineral content. Sustained reductions in serum desacyl‐ghrelin were linked to lower IGF‐1 levels, resulting in significant loss of muscle and bone.
Hiroki Harada, Takuya Goto, Keishi Yamashita, Hiroyuki Minoura, Kota Okuno, Shohei Fujita, Mikiko Sakuraya, Tadashi Higuchi, Koshi Kumagai, Naoki Hiki   +9 more
wiley   +1 more source

Combined anterior pituitary function test using CRH, GRH, LH-RH, TRH and vasopressin in patients with non-functioning pituitary tumors. [PDF]

, 1990
We examined 8 normal subjects and 16 patients with non-functioning pituitary tumors with a combined anterior pituitary test to evaluate the clinical usefulness of the test.
Hashimoto, Kozo, Hirasawa, Ryuto, Kageyama, Jingo, Makino, Shinya, Ogasa, Takashi, Ota, Zensuke, Takao, Toshihiro   +6 more
core   +1 more source

Growth Hormone Promotes Lipolysis and Impairs Insulin Sensitivity by Activating the ERK/HSL Signaling Pathway in Bovine Adipocytes

Animal Research and One Health, EarlyView.
This study was to evaluate the role of GH in lipolysis and insulin sensitivity in bovine adipocytes and clarify the underlying mechanism. Our findings demonstrate that GH activates ERK/HSL signaling pathway, promotes lipolysis, and impairs insulin sensitivity in bovine adipocytes.
Xinxing Gao, Hao Yu, Erminio Trevisi, Cai Lin, Zhiyuan Fang, Xinwei Li, Yuxiang Song, Wenwen Gao, Lin Lei, Xiliang Du, Guowen Liu   +10 more
wiley   +1 more source

Developmental and functional effects of steroid hormones on the neuroendocrine axis and spinal cord [PDF]

, 2016
This review highlights the principal effects of steroid hormones at central and peripheral levels in the neuroendocrine axis. The data discussed highlight the principal role of oestrogens and testosterone in hormonal programming in relation to sexual ...
Gonzalez Deniselle, Maria Claudia, Lara, H. E., Recabarren, S. E., Roselli, C. E., Zubeldia Brenner, Lautaro   +4 more
core   +2 more sources

Tissue-specific regulation of pituitary proopiomelanocortin gene transcription by corticotropin-releasing hormone, 3',5'-cyclic adenosine monophosphate, and glucocorticoids.

Molecular Endocrinology, 1987
The release of pituitary hormones derived from POMC is under multihormonal and tissue-specific control in the anterior and intermediate lobes of the pituitary where the same single-copy POMC gene is expressed. In order to assess the tissue-specificity of
J. Gagner, J. Drouin
semanticscholar   +1 more source

Pharmacokinetics of betamethasone in pre‐eclampsia: An in vivo and ex vivo study

British Journal of Clinical Pharmacology, EarlyView.
Aims To enhance understanding of betamethasone and its metabolites' pharmacokinetics in pregnancy, specifically early‐onset pre‐eclampsia, through a population pharmacokinetic model. Additionally, to investigate the placental metabolism and transfer of betamethasone and its main metabolites.
Sam Schoenmakers, Letao Li, Anna C. M. Kluivers, Michelle Broekhuizen, Madhavi S. Harhangi, A. H. Jan Danser, Irwin Reiss, Karel Allegaert, Sjoerd A. A. van den Berg, Bertrand D. van Zelst, Ron H. N. van Schaik, Philip L. J. DeKoninck, Emma Ronde, Sebastiaan D. T. Sassen, Sinno H. P. Simons, Birgit C. P. Koch   +15 more
wiley   +1 more source

Variable Thyroid-Stimulating Hormone Dynamics in ‘Silent’ Thyrotroph Adenomas

AACE Clinical Case Reports, 2016
: Objective: Pituitary adenomas that produce thyroid-stimulating hormone (TSH) are typically accompanied by hyperthyroxinemia and a non-suppressed or elevated TSH at diagnosis.
Nigel Glynn, MB, Anne Marie Hannon, MB, Michael Farrell, MD, Francesca Brett, MD, Mohsen Javadpour, MD, Amar Agha, MD   +5 more
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