Results 101 to 110 of about 162,638 (311)

Efficacy of hormone pre‐treatment before ART to improve reproductive outcomes in infertile women with endometriosis: Network meta‐analysis of randomized controlled trials

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Hormone pre‐treatment is still used before assisted reproductive technique (ART) in endometriotic women, but evidence supporting this recommendation is conflicting. Objectives To evaluate whether hormone pre‐treatment with gonadotropin‐releasing hormone (GnRH) agonists or progestogens could improve fertility in women with ...
Gaetano Riemma, Luigi Cobellis, Antonio Simone Laganà, Andrea Etrusco, Luigi Della Corte, Marco Torella, Maria Giovanna Vastarella, Raffaela Maria Carotenuto, Pasquale De Franciscis   +8 more
wiley   +1 more source

A Case of Advanced Renal Cell Carcinoma With Concomitant Development of Multiple Endocrine Neoplasia Type 1 That Affected Treatment Progress With Immunotherapy

IJU Case Reports, EarlyView.
ABSTRACT Introduction Hypercalcemia is a poor prognostic factor in advanced cancer. Case Presentation A patient with advanced clear cell renal carcinoma with hypercalcemia was treated with nivolumab+ipilimumab combination therapy. Treatment was discontinued after 4 months due to renal dysfunction.
Masataka Abe, Yoshiyuki Miyaji, Seitetsu Sugiyama, Kiwami Tsurui, Hirofumi Morinaka, Mikako Kaifu, Hiroyuki Kadoya, Wataru Saito, Koji Yoshida, Kazumasa Komura   +9 more
wiley   +1 more source

Safety Evaluation of Serendipity Berry Sweet Protein From Komagataella phaffii

Journal of Applied Toxicology, EarlyView.
ABSTRACT Serendipity Berry Sweet Protein (sweelin) is a novel hyper‐sweet thermophilic protein designed using Artificial Intelligence Computational Protein Design (AI‐CPD) to improve the stability and sensory profile of the protein found in serendipity berry (Dioscoreophyllum cumminsii).
Yael Lifshitz, Shira Paz, Rotem Saban, Inbar Zuker, Hagay Shmuely, Katy Gorshkov, Jwar Meetro, Shahrzad Tafazoli, Trung Vo, Gabriela Amiram, Carmit Shani Levi, Uri Lesmes, Ilan Samish   +12 more
wiley   +1 more source

Parallel expression patterns of NR4A nuclear receptor family genes in the pituitary gland of proestrus rats

The Journal of Reproduction and Development
The NR4A nuclear receptor family (NR4As), encompassing NR4A1, NR4A2, and NR4A3, exerts pivotal roles in cellular processes through intricate expression patterns and interactions.
Ryota TERASHIMA, Daiki NAGAO, Masato IKEO, Keisuke MORIOKA, Titaree LAOHARATCHATATHANIN, Shiro KURUSU, Mitsumori KAWAMINAMI   +6 more
doaj   +1 more source

A high-throughput analysis of ovarian cycle disruption by mixtures of aromatase inhibitors [PDF]

arXiv, 2016
Background: Combining computational toxicology with ExpoCast exposure estimates and ToxCast assay data gives us access to predictions of human health risks stemming from exposures to chemical mixtures. Objectives: To explore, through mathematical modeling and simulations, the size of potential effects of random mixtures of aromatase inhibitors on ...
arxiv  

Multi-responsiveness of single anterior pituitary cells to hypothalamic-releasing hormones: a cellular basis for paradoxical secretion.

Proceedings of the National Academy of Sciences of the United States of America, 1997
The classic view for hypothalamic regulation of anterior pituitary (AP) hormone secretion holds that release of each AP hormone is controlled specifically by a corresponding hypothalamic-releasing hormone (HRH).
C. Villalobos, L. Núñez, Frawley Ls, J. García-Sancho, Ana Sánchez   +4 more
semanticscholar   +1 more source

Allergenicity, Genotoxicity and Subchronic Toxicity Assessment of IgG Binding Protein LT Produced From Aspergillus oryzae

Journal of Applied Toxicology, EarlyView.
ABSTRACT Gastrointestinal health is one of the fastest growing areas in the food and beverage industry, as its importance to overall health and well‐being is becoming increasingly recognized. Immunoglobulins play a key role in protecting the gastrointestinal tract, and nonbovine sources of immunoglobulins (including camel milk, which has a long history
Kirt R. Phipps, Sachin Patel, Kevin Scaife, Toby Holmes, Alica Šoltésová, Sandra Wingaard Thrane, Louise Kristine Vigsnæs, Nigel Baldwin, Christel Jørgensen   +8 more
wiley   +1 more source

Mathematical Modeling of Perifusion Cell Culture Experiments on GnRH Signaling [PDF]

arXiv, 2015
The effects of pulsatile GnRH stimulation on anterior pituitary cells are studied using perifusion cell cultures, where constantly moving medium over the immo- bilized cells allows intermittent GnRH delivery. The LH content of the outgoing medium serves as a readout of the GnRH signaling pathway activation in the cells.
arxiv  

Critical roles of endogenous glucocorticoids for disease tolerance in malaria

, 2019
During malaria, the hypothalamic-pituitary-adrenal (HPA) axis is activated and glucocorticoid (GC) levels are increased, but their essential roles have been largely overlooked.
De Bosscher, Karolien, Opdenakker, Ghislain, Van den Steen, Philippe E., Vandermosten, Leen, Vanhorebeek, Ilse   +4 more
core   +1 more source

Physiologically Based Pharmacokinetic (PBPK) Model to Predict the Magnitude of Drug–Drug Interaction Between Fezolinetant and CYP1A2 Inhibitors

The Journal of Clinical Pharmacology, EarlyView.
Abstract Fezolinetant is a non‐hormonal, selective neurokinin 3 receptor antagonist approved in multiple countries including the United States, in Europe, and in Asia for the treatment of moderate to severe vasomotor symptoms in menopausal women. Fezolinetant is primarily metabolized by CYP1A2 and was found to be a sensitive substrate for CYP1A2 ...
Mary P. Choules, Yukio Otsuka, Jace C. Nielsen, Megumi Iwai, Peter L. Bonate   +4 more
wiley   +1 more source