Results 111 to 120 of about 828,117 (319)

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

Aromatase cytochrome P450 enzyme expression in human pituitary

, 2008
Aromatase (P450AROM) converts testosterone to estrogen. This conversion could be important in normal physiology and estradiol-induced tumorigenesis in human pituitary.
Erensoy, Nevin, Kadioglu, Pınar, Senel, Berna, Kadioglu, Pinar, Oral, Gökhan, Ozbek, Ugur, Sav, Aydin, Cetin, Gürsel, Sayitoglu, Müge, Gazioglu, Nurperi   +9 more
core   +2 more sources

The birth and rise of a craniopharyngioma: the radiological evolution of an incidental craniopharyngioma detected on serial MRI during medical treatment of a macroprolactinoma

Clinical Case Reports, 2017
Key Clinical Message This case demonstrates the rare coexistence of a prolactinoma with craniopharyngioma and documents its radiological growth.
Stefano Mariotti, Marco Losa, Pietro Mortini, Luca Saba   +3 more
doaj   +1 more source

A Recessive Mutation Resulting in a Disabling Amino Acid Substitution (T194R) in the LHX3 Homeodomain Causes Combined Pituitary Hormone Deficiency [PDF]

, 2012
Background/Aims: Recessive mutations in the LHX3 homeodomain transcription factor gene are associated with developmental disorders affecting the pituitary and nervous system. We describe pediatric patients with combined pituitary hormone deficiency (CPHD)
Hiedl, Stefan, Duran-Prado, Mario, Lohse, Peter, Roeb, Julia, Rhodes, Simon J., Malik, Raleigh E., Bechtold-Dalla Pozza, Susanne, Park, Soyoung   +7 more
core   +1 more source

The influence of a systemic non‐steroidal anti‐inflammatory drug on growth factors and cytokines in equine plasma, solid platelet‐rich fibrin (PRF), and liquid PRF

Equine Veterinary Journal, EarlyView.
Abstract Background Platelet‐rich fibrin (PRF) is a second‐generation platelet concentrate that contains growth factors and cytokines within a fibrin matrix, allowing prolonged release and supporting its use as a regenerative therapy for corneal wound healing.
Katrina E. V. Jones, Kimberly Young, Erin Barr, Chongben Zhang, Cody McGrath, Kimberly R. Love, Brian Gilger, Michala de Linde Henriksen   +7 more
wiley   +1 more source

Imaging Recommendations for Diagnosis, Staging, and Management of Primary Central Nervous System Neoplasms in Adults

Neuroglia
Central nervous system (CNS) neoplasms are a vast and diverse group of tumors in adults with variable prognoses depending on histology and increasingly understood molecular features.
Kajari Bhattacharya, Abhishek Mahajan
doaj   +1 more source

Syncing Health Timing: Exploring the Interplay of Circadian Rhythms, Obesity, and Cardiovascular Diseases

Food Safety and Health, EarlyView.
Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima, István Dalmadi, Anna Jánosi, Krisztina Takács, Eszter Halmy   +4 more
wiley   +1 more source

The Epigenomics of Pituitary Adenoma

Frontiers in Endocrinology, 2019
Background: The vast majority of pituitary tumors are benign and behave accordingly; however, a fraction are invasive and are more aggressive, with a very small fraction being frankly malignant.
Blake M. Hauser, Ashley Lau, Saksham Gupta, Wenya Linda Bi, Ian F. Dunn   +4 more
doaj   +1 more source

Stereotactic Body Radiation Therapy for Head and Neck Cancers With Perineural Spread

Head &Neck, EarlyView.
ABSTRACT Background Perineural spread (PNS) in head and neck cancer (HNC) is technically challenging due to complex target volumes adjacent to critical organs. Data on stereotactic body radiation therapy (SBRT) for PNS is scarce. Methods This retrospective study included patients treated with SBRT for PNS across two centers in the USA and Canada from ...
Anna K. Lawless, Christopher D. Goodman, Catherine H. Wang, Xin W. Wang, Steven J. Frank, Clifton D. Fuller, Adam S. Garden, G. Brandon Gunn, Amy C. Moreno, William H. Morrison, Jay P. Reddy, David I. Rosenthal, Michael T. Spiotto, Neil D. Gross, Ehab Y. Hanna, Shirley Y. Su, Michael R. Migden, Neal S. Akhave, Renata Ferrarotto, Moran Amit, Anna Lee, Jack Phan   +21 more
wiley   +1 more source

Mutation analysis of inhibitory guanine nucleotide binding protein alpha (GNAI) loci in young and familial pituitary adenomas.

PLoS ONE, 2014
Pituitary adenomas are neoplasms of the anterior pituitary lobe and account for 15-20% of all intracranial tumors. Although most pituitary tumors are benign they can cause severe symptoms related to tumor size as well as hypopituitarism and/or ...
Hande Demir, Iikki Donner, Leena Kivipelto, Outi Kuismin, Camilla Schalin-Jäntti, Ernesto De Menis, Auli Karhu   +6 more
doaj   +1 more source