Results 51 to 60 of about 235,360 (304)

Non‐Additive Criteria Assessment in Sustainability Evaluation of High Entropy Alloys: A Toxicity‐Weighted Framework

Advanced Engineering Materials, EarlyView.
Sustainability assessment requires methodologies that appropriately distinguish between additive and non‐additive material properties. A toxicity‐weighted scoring system is developed and applied that accounts for the disproportionate influence of highly toxic constituents through nonlinear weighting functions, providing more realistic estimates than ...
Seth Mehalic, Oladele A. Ogunseitan, Julie M. Schoenung   +2 more
wiley   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

The neuropsychological effects of pituitary macroadenomas and their treatment [PDF]

, 2005
Pituitary adenomas account for roughly 12% of all intracranial tumours and are treated either surgically or medically. Due to the prevalence, there have been many articles focusing on their treatment.
Mark, Daniella
core   +1 more source

DIABETES INSIPIDUS: LITTLE-KNOWN FACTS

Исследования и практика в медицине, 2019
The most common causes of diabetes insipidus are neurosurgical operations on the pituitary gland due to its defeat by benign and malignant tumors, the neoplasms themselves, lymphocytic hypophysitis.
L. Yu. Morgunov
doaj   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Epigenetic Activation of SOX11 in Lymphoid Neoplasms by Histone Modifications [PDF]

, 2011
Recent studies have shown aberrant expression of SOX11 in various types of aggressive B-cell neoplasms. To elucidate the molecular mechanisms leading to such deregulation, we performed a comprehensive SOX11 gene expression and epigenetic study in stem ...
Amador Virginia, Ott, G. (German), Royo Cristina, Palomero, J. (Jara), Agirre, Xabier, Salaverria Frigola, Itziar, Manel Esteller, Román-Gómez, José, Esteller, Manel, Balazs Balint, Andreas Rosenwald, Xargay-Torrent Silvia, Martín-Guerrero Idoia, Rosenwald, Andreas, Campo, E. (Elías), Pedro Jares, Royo Moreno, Cristina, Royo, Cristina, Hernández, Luis, Vegliante Maria Carmela, Rosenwald Andreas, Siebert, Reiner, Siebert Reiner, Martin-Guerrero, I. (Idoia), Balint, B. (Balazs), Jares, P. (Pedro), Calasanz María José, Prosper Felipe, Esteller Manel, Palomero Jara, Reiner Siebert, Agirre Xabier, Calasanz, María José, Bea Silvia, Roman-Gomez José, Vegliante, M.C. (Maria Carmela), Campo Elias, Silvia Bea, Lujambio, A. (Amaya), Beà Bobet, Sílvia M., Jose Calasanz, Maria, Roman-Gomez, J. (José), Vegliante, Maria Carmela, Maria Carmela Vegliante, María José Calasanz, Balint Balazs, Luis Hernandez, Enjuanes Anna, Enjuanes, A. (Anna), Felipe Prosper, Balint, Balazs, Martin-Subero, J.I. (Jose Ignacio), Salaverria, Itziar, Richter, Julia, Martín Guerrero, Idoia, Ott, German, Jares Gerboles, Pedro, Xargay-Torrent, S. (Silvia), Martín-Subero José I., Amaia Lujambio, Cristina Royo, José Roman-Gomez, José I Martín-Subero, Maria Carmela Vegliante, Martin-Guerrero, Idoia, Anna Enjuanes, Carmela Vegliante, Maria, Salaverria-Lete, I. (Itziar), Richter, J. (Julia), Esteller, M. (Manel), Martin-Subero, Jose I., Richter Julia, Bea, Silvia, Rosenwald, A. (Andreas), Xargay-Torrent, Silvia, Jares Pedro, Royo, C. (Cristina), Prosper-Cardoso, F. (Felipe), Campo Güerri, Elias, José I. Martín-Subero, Campo, Elias, Idoia Martín-Guerrero, Ott German, Calasanz-Abinzano, M.J. (Maria Jose), Lujambio, Amaia, Hernandez, L. (Luis), Palomero, Jara, Silvia Xargay-Torrent, Jares, Pedro, Hernandez Luis, Lujambio Amaia, Virginia Amador, German Ott, Jara Palomero, Bea, S. (Silvia), Elias Campo, Amador, V. (Virginia), Xargay i Torrent, Sílvia, Julia Richter, Salaverria Itziar, Siebert, R. (Reiner), Amador, Virginia, Enjuanes, Anna, Aguirre-Ena, X. (Xabier), Itziar Salaverria, Prosper, Felipe, Xabier Agirre, Esteller, Manel, 1968-   +107 more
core   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

Concurrent Adrenal and Pituitary Adenomas in a Dog: A Case Report of Cushing's Disease

Cluj Veterinary Journal
Neoplasms of endocrine organs occur in all animal species and are more commonly observed in dogs, cats, and horses. The simultaneous occurrence of pituitary and adrenal gland neoplasia can appear isolated or as a part of multiple endocrine neoplasias ...
Ecaterina Semzenisi, Romelia Pop, Dragoș Hodor, Alexandra Morar, Ibrahima Mamadou Sall, Flaviu Tabaran   +5 more
doaj   +1 more source

Gene Expression and the Physiological Role of Transforming Growth Factor-α in the Mouse Pituitary [PDF]

, 2003
Transforming growth factor-alpha (TGF-alpha), a member of the epidermal growth factor (EGF) family, is produced within the mouse anterior pituitaries. However, the cell types of TGF-alpha-expressing cells and the physiological roles of TGF-a within mouse
Kakeya, Tomoshi, Takahashi, Sumio, Takeuchi, Sakae, Oomizu, Souichi, Sharma, Seema, Masui, Tohru   +5 more
core   +1 more source