Results 31 to 40 of about 3,817 (121)

Investigating a Prognostic Factor for Canine Hepatocellular Carcinoma: Analysis of Different Histological Grading Systems and the Role of PIVKA-II

Veterinary Sciences, 2022
Background: Hepatocellular carcinoma (HCC) in dogs is uncommon and often associated with a good prognosis, although some cases prove to be aggressive. In human oncology HCC is often very aggressive and diagnostic methods and prognostic factors are widely
Lorella Maniscalco, Katia Varello, Emanuela Morello, Vittoria Montemurro, Matteo Olimpo, Davide Giacobino, Giuseppina Abbamonte, Cecilia Gola, Selina Iussich, Elena Bozzetta   +9 more
doaj   +1 more source

Usefulness of PIVKA-II for monitoring after liver transplantation in patients with hepatocellular carcinoma

Scientific Reports, 2023
The high morbidity and mortality of hepatocellular carcinoma (HCC) has encouraged the search for new biomarkers to be used alongside alpha-foetoprotein (AFP) and imaging tests.
Francisco Villalba-López, Luis Francisco Sáenz-Mateos, Maria Isabel Sánchez-Lorencio, Virginia De La Orden-García, Felipe Alconchel-Gago, Pedro Antonio Cascales-Campos, Carmen García-Bernardo, José Antonio Noguera-Velasco, Alberto Baroja-Mazo, Pablo Ramírez-Romero   +9 more
doaj   +1 more source

Effectiveness of PIVKA-II in the detection of hepatocellular carcinoma based on real-world clinical data

BMC Cancer, 2017
Background Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) is an efficient biomarker specific for hepatocellular carcinoma (HCC). Some researchers have proved that levels of PIVKA-II reflect HCC oncogenesis and progression.
Rentao Yu, Zhaoxia Tan, Xiaomei Xiang, Yunjie Dan, Guohong Deng   +4 more
doaj   +1 more source

Ontogenetic view on PIVKA-II in the development of prothrombin synthesis in infants

Patologìâ, 2017
The aim of the research was to study the content of PIVKA-II in the blood serum as an integrative measure of latent vitamin K deficiency in breastfed infants aged from the birth to 6 months of life. Materials and methods.
O. G. Ivanko, A. V. Solianik, I. V. Pashchenko   +2 more
doaj   +1 more source

Assessment of measuring PIVKA-II Versus Alpha-Fetoprotein in Diagnosing Hepatocellular Carcinoma: A Stratification by Child-Pugh Classification [PDF]

Zagazig University Medical Journal
Background: Alpha-fetoprotein (AFP) is the primary serum biomarker for hepatocellular carcinoma (HCC), but its diagnostic performance is limited. Protein induced by vitamin K absence II (PIVKA-II) is a potential complement, though its value is debated ...
Ayman Mohammed, Yasser El Naggar, Moataz Youssef Mobasher, Ahmed El Agroudy, Haidy Zidan   +4 more
doaj   +1 more source

Abnormal Prothrombin (PIVKA-II) Expression in Canine Tissues as an Indicator of Anticoagulant Poisoning

Animals, 2021
PIVKA-II is an aberrant form of vitamin K that has been demonstrated to be increased in human coagulation disorders and in some neoplastic diseases.
Lorella Maniscalco, Katia Varello, Simona Zoppi, Giuseppina Abbamonte, Marta Ferrero, Elena Torres, Federica Ostorero, Francesca Rossi, Elena Bozzetta   +8 more
doaj   +1 more source

Unclassified hepatocellular adenoma with histological brown pigment deposition and serum PIVKA-II level elevation: a case report

Surgical Case Reports, 2020
Background Hepatocellular adenoma (HCA) is conventionally considered a rare benign liver tumor, but advanced studies have revealed that HCA is heterogeneous, and may include a type that is prone to malignant transformations.
Kouki Hoshino, Norifumi Harimoto, Ryo Muranushi, Kei Hagiwara, Takahiro Yamanaka, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichiro Araki, Ran Tomomasa, Sumihito Nobusawa, Shinichi Aishima, Osamu Nakashima, Ken Shirabe   +15 more
doaj   +1 more source

Engineered molecular diagnostic strategies for hepatocellular carcinoma: Integrating flexible photonic barcodes, liquid biopsies, and AI‐enhanced sensing platforms

FlexMat, EarlyView.
Abstract Early diagnosis of hepatocellular carcinoma (HCC) remains challenging because conventional serum biomarkers, especially alpha‐fetoprotein (AFP), show limited sensitivity for early‐stage disease. Recent progress in engineered molecular diagnostics provides new opportunities to improve HCC detection through integrated material, molecular, and ...
Jingzhi Xue, Wanqi Yang, Xiaoyu Liu, Xuehui Chu, Wei Li, Jinglin Wang   +5 more
wiley   +1 more source

Range of protein induced by vitamin K absence or antagonist-II levels in neonates at birth

Scientific Reports
Protein induced by vitamin K absence or antagonist-II (PIVKA-II) is avitamin K (VK) deficiency indicator in neonates. However, PIVKA-II detection frequency in neonatal blood at birth and the correlation between PIVKA-II and gestational age are unclear ...
Tomohiro Sameshima, Mariko Ashina, Takuya Fukuda, Takumi Kido, Shinya Abe, Yuko Watanabe, Itsuko Sato, Yoshihiko Yano, Kenji Tanimura, Hiroaki Nagase, Kandai Nozu, Kazumichi Fujioka   +11 more
doaj   +1 more source

When Explant Surprises: Management and Outcomes of Hepatocellular Carcinoma Beyond Milan Criteria Discovered Post‐Transplant‐ A Narrative Review of Literature

Journal of Surgical Oncology, EarlyView.
ABSTRACT Liver transplantation (LT) is the definitive treatment for early hepatocellular carcinoma (HCC), based on established criteria. Pre‐transplant imaging occasionally underestimates the tumor burden or biological aggressiveness, leading to explant pathology that exceeds the projection criteria, such as Milan.
Serkan Sucu, Brian Longbottom, Hassan Aziz   +2 more
wiley   +1 more source