Utility of combining PIVKA-II and AFP in the surveillance and monitoring of hepatocellular carcinoma in the Asia-Pacific region [PDF]
Clinical and Molecular Hepatology, 2023 Even though the combined use of ultrasound (US) and alpha-fetoprotein (AFP) is recommended for the surveillance of hepatocellular carcinoma (HCC), the utilization of AFP has its challenges, including accuracy dependent on its cut-off levels, degree of ...
Do Young Kim +16 more
doaj +4 more sources
Ontogenetic view on PIVKA-II in the development of prothrombin synthesis in infants
Patologìâ, 2017 The aim of the research was to study the content of PIVKA-II in the blood serum as an integrative measure of latent vitamin K deficiency in breastfed infants aged from the birth to 6 months of life. Materials and methods.
O. G. Ivanko +2 more
doaj +3 more sources
BioMedica, 2021 Background and Objective: PIVKA-II (Protein induced by vitamin K absence II) is an upcoming and promising new biological marker cited as having a definitive role in the early detection and diagnosis of hepatocellular carcinoma (HCC).
Faryal Husnain +5 more
doaj +2 more sources
Animals, 2021 PIVKA-II is an aberrant form of vitamin K that has been demonstrated to be increased in human coagulation disorders and in some neoplastic diseases.
Lorella Maniscalco +8 more
doaj +2 more sources
Impact of PIVKA-II in diagnosis of hepatocellular carcinoma
Journal of Advanced Research, 2013 Liver cancer grows silently with mild or no symptoms until advanced. In the absence of an effective treatment for advanced stage of hepatic cancer hope lies in early detection, and screening for high-risk population. Among Egyptians viral hepatitis is the most common risk factor for hepatocellular carcinoma (HCC).
Hanan E Shafik
exaly +4 more sources
Biological variation of PIVKA-II in blood serum of healthy subjects measured by automated electrochemiluminescent assay [PDF]
Practical Laboratory MedicineBackground: Prothrombin/Protein Induced by Vitamin K Absence-II (PIVKA-II) is a candidate biomarker of hepatocellular cancer, recommended both for diagnostics and monitoring. The aim was to evaluate biological variation (BV) of serum PIVKA-II.
Antonín Jabor +5 more
doaj +2 more sources
Clinical significance of AFP and PIVKA-II for predicting prognosis in hepatocellular carcinoma patients treated with immune checkpoint inhibitors [PDF]
Therapeutic Advances in Medical OncologyBackground: Alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) are classical tumor markers in clinical practice.
Shanshan Jiang +10 more
doaj +2 more sources
Gut and Liver, 2015 Background/AimsProthrombin induced by vitamin K deficiency or antagonist II (PIVKA-II) is a widely used diagnostic marker for hepatocellular carcinoma (HCC).
doaj +2 more sources
Investigating a Prognostic Factor for Canine Hepatocellular Carcinoma: Analysis of Different Histological Grading Systems and the Role of PIVKA-II [PDF]
Veterinary Sciences, 2022 Background: Hepatocellular carcinoma (HCC) in dogs is uncommon and often associated with a good prognosis, although some cases prove to be aggressive. In human oncology HCC is often very aggressive and diagnostic methods and prognostic factors are widely
Lorella Maniscalco +9 more
doaj +2 more sources
Long-Term Prognostic Value of AFP and PIVKA-II in HCC After Living Donor Liver Transplantation: A Single-Center Retrospective Study [PDF]
Transplant InternationalDespite the development of numerous prognostic models for hepatocellular carcinoma (HCC) recurrence and mortality after liver transplantation, tumor biomarkers such as alpha-fetoprotein (AFP) and protein induced by vitamin K absence-II (PIVKA-II) remain ...
Saran Ochir Gongor +14 more
doaj +2 more sources