Results 1 to 10 of about 10,900,499 (194)

Diagnostic Performance of PIVKA-II in Italian Patients with Hepatocellular Carcinoma. [PDF]

Cancers (Basel)
Background and Aims: Hepatocellular carcinoma (HCC) represents the second leading cause of cancer deaths worldwide. Six-month imaging along with alpha-fetoprotein (AFP) serum levels detection are the current gold standard to exclude HCC. Protein induced by vitamin K absence (PIVKA-II) has been proposed as a potential screening biomarker for HCC.
Guarneri V, Loggi E, Ramacieri G, Serra C, Vukotic R, Vitale G, Scuteri A, Cursaro C, Margotti M, Galli S, Caracausi M, Brodosi L, Gabrielli F, Andreone P.   +13 more
europepmc   +7 more sources

Diagnostic performance of PIVKA-II in identifying recurrent hepatocellular carcinoma following curative resection: a retrospective cohort study [PDF]

Scientific Reports
Protein induced by vitamin K absence or antagonist II (PIVKA-II) plays a critical role in the diagnosis of hepatocellular carcinoma (HCC), however, studies on its efficacy in diagnosing recurrent HCC were rarely found.
Wenfeng Zhu, Weilong Wang, Wenjie Zheng, Xiaolong Chen, Xiaowen Wang, Juping Xie, Shijie Jiang, Haoqi Chen, Shuguang Zhu, Ping Xue, Xiaofeng Jiang, Hua Li, Genshu Wang   +12 more
doaj   +4 more sources

Effect of AFP and PIVKA-II secretion status on prognosis of advanced hepatocellular carcinoma patients receiving TACE combined with systemic therapy [PDF]

BMC Cancer
Background Few biomarkers can predict the effectiveness of transcatheter arterial chemoembolization (TACE) in combination with systemic therapies for patients with advanced hepatocellular carcinoma (HCC).
Jinfeng Bai, Jinmei Zhou, Xin Zhao, Jianjie Hua, Wenqi Li, Fangfang Xiong, Rong Ding   +6 more
doaj   +3 more sources

Diagnostic and prognostic performance of serum GPC3 and PIVKA-II in AFP-negative hepatocellular carcinoma and establishment of nomogram prediction models [PDF]

BMC Cancer
Objective A significant proportion, ranging from 20 to 40%, of individuals with hepatocellular carcinoma (HCC) do not exhibit elevated Alpha-fetoprotein (AFP) levels. This study aimed to evaluate the utility of serum glypican-3 (GPC3) and protein induced
Yingying Lin, Yuefei Ma, Yan Chen, Yepei Huang, Jinchuan Lin, Zhenzhou Xiao, Zhaolei Cui   +6 more
doaj   +3 more sources

PIVKA-II as a surrogate biomarker for therapeutic response in Non-AFP-secreting hepatocellular carcinoma [PDF]

BMC Cancer
Background Alpha-fetoprotein (AFP) is a key biomarker for hepatocellular carcinoma (HCC), but 30–40% of cases are AFP-negative. Prothrombin induced by vitamin K absence II (PIVKA-II) is more sensitive for HCC detection, though its role in systemic ...
San-Chi Chen, Hsiang-Ling Ho, Chien-An Liu, Yi‑Ping Hung, Nai-Jung Chiang, Ming‑Huang Chen, Yee Chao, Muh-Hwa Yang   +7 more
doaj   +3 more sources

Clinical significance of AFP and PIVKA-II for predicting prognosis in hepatocellular carcinoma patients treated with immune checkpoint inhibitors [PDF]

Therapeutic Advances in Medical Oncology
Background: Alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) are classical tumor markers in clinical practice.
Shanshan Jiang, Yuyang Wang, Xiaona Fu, Jie Lou, Bingxin Gong, Weiwei Liu, Yi Li, Yuxin Sun, Chunfeng Liu, Zifang Song, Guofeng Zhou   +10 more
doaj   +3 more sources

NQO1/p65/CXCL12 Axis‐Recruited Tregs Mediate Resistance to Anti‐PD‐1 Plus Lenvatinib Therapy in PIVKA‐II‐Positive Hepatocellular Carcinoma [PDF]

Advanced Science
Immune checkpoint inhibitors (ICIs) combined with anti‐angiogenic agents manifest improved survival in advanced hepatocellular carcinoma (HCC), but responses remain heterogeneous.
Biao Gao, Yafei Wang, Zhuoya Sun, Haowen Tang, Yinbiao Cao, Hao Jiang, Wenwen Zhang, Yinzhe Xu, Bingyang Hu, Zhe Liu, Guankun Mao, Xuerui Li, Junfeng Li, Tao Wan, Bing Liu, Xiao Zhao, Shunchang Jiao, Chonghui Li, Shichun Lu   +18 more
doaj   +3 more sources

Long-Term Prognostic Value of AFP and PIVKA-II in HCC After Living Donor Liver Transplantation: A Single-Center Retrospective Study [PDF]

Transplant International
Despite the development of numerous prognostic models for hepatocellular carcinoma (HCC) recurrence and mortality after liver transplantation, tumor biomarkers such as alpha-fetoprotein (AFP) and protein induced by vitamin K absence-II (PIVKA-II) remain ...
Saran Ochir Gongor, YoungRok Choi, YoungRok Choi, Gayoung Kim, Min Kyoung Kim, Sang Hyuk Park, Jiyoung Kim, Jae-Yoon Kim, Jae-Yoon Kim, Su young Hong, Jeong-Moo Lee, Suk Kyun Hong, Suk Kyun Hong, Kwang-Woong Lee, Kwang-Woong Lee   +14 more
doaj   +3 more sources

Pilot Study of PIVKA-II in the Prognostic Assessment of Hepatocellular Carcinoma in Chronic Viral Hepatitis: Comparative Findings from HBV and HCV Cohorts from a Single Center in Serbia [PDF]

Biomedicines
Background: Hepatocellular carcinoma (HCC) frequently develops in patients with chronic hepatitis B and C. Early detection is critical, but current methods, including ultrasound and AFP, have suboptimal accuracy.
Ivana Milošević, Nataša Nikolić, Sanja Stanković, Ana Filipović, Jovana Ranin, Irena Paunović, Jelena Simić, Branko Beronja   +7 more
doaj   +3 more sources

Combining AFP, PIVKA-II, and GP73 has diagnostic utility for hepatitis B-associated hepatocellular carcinoma and is consistent with liver pathology results [PDF]

Scientific Reports
Although liquid biopsy has garnered increasing attention in recent years for diagnosing hepatocellular carcinoma (HCC), serum biomarkers continue to hold significant value for HCC diagnosis due to their simple operation, cost-effectiveness, and high ...
Hu Rui, Ni Yueqin, Wang Wei, Li Bangtao, Xiao Li   +4 more
doaj   +3 more sources