Results 81 to 90 of about 4,156,285 (177)

A Protein‐Centric Strategy Coupled with Match‐Between‐Run Glycoproteomics Enables Discovery of Robust Site‐Specific Glycan Biomarkers for Hepatocellular Carcinoma

Advanced Science, Volume 13, Issue 22, 17 April 2026.
In this study, a highly robust N‐glycoproteomics (HRN) platform with a newly developed match‐between‐run scheme is used for biomarker discovery. This study proposes a protein‐centric strategy to prioritize proteins susceptible to aberrant glycosylation.
Lei Liu, Taiheng Ma, Qi Liu, He Zhu, Zheng Fang, Jiahong Ma, Ting Yu, Yan Wang, Jiahua Zhou, Xiaoyan Liu, Yaqian Li, Zhimou Guo, Xinmiao Liang, Mingming Dong, Deguang Sun, Mingliang Ye   +15 more
wiley   +1 more source

Global Advances in Hepatocellular Carcinoma Research and Therapy in 2025

Cancer Innovation, Volume 5, Issue 2, April 2026.
This review summarizes key breakthrough advances in hepatocellular carcinoma (HCC) reported in 2025 and presents a multidisciplinary management framework for HCC, integrating early diagnosis, microenvironment insights, and comprehensive therapeutic strategies spanning minimally invasive surgery, locoregional interventions, and systemic pharmacotherapy.
Bo Hu, Qiang Gao
wiley   +1 more source

PIVKA-II plasma levels as markers of subclinical vitamin K deficiency in term infants

, 2012
Background: As the vitamin K content of human milk is low and the newborn infant's stores of vitamin K are small, vitamin K deficiency with hemorrhage in the newborn is a worldwide problem.
Dituri, F., R. Agostino, Cortesi, M., Agostino, R., Naddeo, F., F. Naddeo, Buonocore, G., Tataranno, M. L., F. Dituri, P. Pasqualetti, G. Buonocore, Pietravalle, A., Pasqualetti, P., M. L. Tataranno, A. Pietravalle, M. Cortesi   +15 more
core   +1 more source

Positioning of novel tumor marker NX-PVKA-R in the diagnosis of hepatocellular carcinoma in comparison with PIVKA-II

, 2013
Background/Aims:To compare the use of protein induced by vitamin K absence or antagonist II( PIVKA-II) measured conventionally with the ratio between PIVKA-II measured using P-11 and P-16 antibodies(NX-PVKA) and PIVKA-II measured conventionally (NX-PVKA ...
Suzuki, Kazutomo, Katayama, Yasumi, Takada, Hiroshi, Suzuki, Kazuyoshi, Tamano, Masaya, Kuniyoshi, Toru   +5 more
core  

Effects of oral and intramuscular vitamin K prophylaxis on PIVKA-II assay parameters in breastfed infants in Turkey

The Turkish Journal of Pediatrics, 1996
Protein induced by vitamin K absence (PIVKA-II) has been used for the evaluation of vitamin K deficiency in the newborn. Differing PIVKA-II detection rates in various studies on hemorrhagic disease of the newborn have not been explained ...
N Uluşahin, S Arsan, F Ertogan
doaj  

Immunohistochemical study for PIVKA-II in hepatocellular carcinoma.

Kanzo, 1991
吸引肝生検で診断された肝細胞癌(HCC)患者70例(A群:腫瘍径2cm以下23例,B群:径2～5cm 13例,C群:径5cm以上および多結節34例)の肝癌組織を抗PIVKA-II抗体を用いた酵素抗体間接法で染色し光顕・電顕的に観察した.HCC 70例のうち組織PIVKA-II染色陽性は29例(41.4%)であった.細胞異型度別の陽性率には有意差を認めなかったが,中等度異型度群(Ed-II)で強く染色される傾向があった.腫瘍径別の陽性率はA群39.1%, B群38.5%, C群44.1%であり,A群での血中PIVKA-II陽性例は1例のみであった.また,腫瘍切除後に血中PIVKA-IIの正常化した症例が認められたことや電顕的に肝癌細胞の粗面小胞体にPIVKA-IIに対する反応産物が認められたことから ...
openaire   +2 more sources

Comparing Prothrombin induced by vitamin K absence-II (PIVKA-II) with the oncofetal proteins Glypican-3, Alpha feto protein and Carcinoembryonic antigen in diagnosing hepatocellular carcinoma among Egyptian patients

Journal of the Egyptian National Cancer Institute, 2014
Background: Hepatocellular carcinoma (HCC) is usually asymptomatic in the early stage and does not show elevated alpha-feto protein (AFP). AFP shows 60–80% sensitivity in diagnosing HCC.
Iman A. Abd El Gawad, Ghada I. Mossallam, Noha H. Radwan, Heba M. Elzawahry, Niveen M. Elhifnawy   +4 more
doaj   +1 more source

Correlation of Neutrophil-Lymphocyte Ratio, Alpha-Fetoprotein, and PIVKA-II with Staging of HCC Related HBV at Dr. Mohammad Hoesin Hospital, Palembang

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Background: The staging of Hepatocellular carcinoma (HCC) requires evaluating the tumor size and number, liver function, physical performance, tumor invasion, extrahepatic metastasis, and clinical symptoms. Biomarkers such as neutrophil-lymphocyte ratio (
Febry Rahmayani, Suyata Suyata, Legiran .   +2 more
doaj   +1 more source

Clinical usefulness of double biomarkers AFP and PIVKA-II for subdividing prognostic groups in locally advanced hepatocellular carcinoma

, 2014
BACKGROUND & AIMS: In this study, we investigated the clinical usefulness of AFP and PIVKA-II in subdividing prognostic groups in patients with locally advanced HCC treated locally. METHODS: Patients who had undergone local treatment for locally advanced
안상훈, 박준용, 김도영, 한광협, 김승업, 성진실   +5 more
core   +1 more source

Do exclusively breastfed infants have vitamin K deficiency? On the 20th anniversary of studying the background

Zdorovʹe Rebenka, 2019
Background. Are breast-fed infants vitamin K deficient? F.R. Greer raised this question in 2001 in his classic study. The purpose of the study was to determine the concentration of prothrombin induced by vitamin K absence II (PIVKA-II) and prothrombin ...
O.G. Ivanko, O.V. Solyanik
doaj   +1 more source