Results 71 to 80 of about 5,801,283 (182)

The diagnostic performance of PIVKA-II in metabolic and viral hepatocellular carcinoma: A pilot study

, 2020
OBJECTIVE: Hepatocellular carcinoma (HCC) is a primary liver tumor derived from metabolic or viral chronic hepatitis, with few treatment options in advanced cases. New biomarkers that allow improving diagnosis and staging are widely desired. Here, we aim
DI GIACINTO F., GASBARRINI A., MARRONE G., RAPACCINI G. L., DE MATTHAEIS N., NAPODANO C., MIELE L., GRIECO A., BIOLATO M., CIASCA G., MARINO M., LIGUORI A., BASILE U., POCINO K.   +13 more
core   +1 more source

PIVKA-II level is correlated to development of portal vein tumor thrombus in patients with HBV-related hepatocellular carcinoma

Infectious Agents and Cancer, 2019
Aim To evaluate the correlation of serum PIVKA-II levels and development of portal vein tumor thrombus (PVTT) in hepatocellular carcinoma (HCC) patients.
Tao Li, Yuanzi Yu, Juan Liu, Xiangguo Tian, Meng Kong, Lei Wu, Shaocan Tang, Shengqing Gu, Jingfang Zhao, Yi Cui, Jinhua Hu   +10 more
doaj   +1 more source

Prognostic Impact of Arterial Phase Hyperenhancement After Proton Beam Therapy for Untreated Solitary Hepatocellular Carcinoma

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Purpose To evaluate the significance of persistent arterial‐phase hyperenhancement (APHE) on contrast‐enhanced CT/MRI at 6 and 12 months after proton beam therapy (PBT) for hepatocellular carcinoma (HCC). Methods We retrospectively analyzed 108 patients with solitary HCC without vascular invasion who underwent definitive PBT as initial ...
Hikaru Niitsu, Masashi Mizumoto, Yinuo Li, Masahiko Harada, Takuya Sawada, Masaaki Goto, Taisuke Sumiya, Keiichiro Baba, Takeshi Fujisawa, Masatoshi Nakamura, Toshiki Ishida, Takashi Iizumi, Takashi Saito, Haruko Numajiri, Kei Nakai, Yoshiko Oshiro, Hideyuki Sakurai   +16 more
wiley   +1 more source

Oncocytoma Arising From an Accessory Adrenal Gland: A Case Report

IJU Case Reports, Volume 9, Issue 5, September 2026.
ABSTRACT Introduction Accessory adrenal oncocytomas are rare. Consequently, the clinical characteristics and management of this entity remain poorly defined. Case Presentation A 65‐year‐old man presented with a retroperitoneal mass. Imaging revealed a 103 × 96 mm tumor adjacent to the left kidney.
Yuki Seki, Kento Morozumi, Naomi Sato, Masaaki Oikawa, Hiroki Kusumoto, Nao Iwamoto, Naoki Kawamorita, Takayuki Yamada, Yasuhiro Nakamura, Yasuhiro Kaiho   +9 more
wiley   +1 more source

PIVKA‑II is associated with liver function, bone metabolism, and muscle function in patients with liver disease. [PDF]

Biomed Rep
Protein induced by vitamin K (VK) absence‑II (PIVKA‑II) is a sensitive marker for diagnosing hepatoma but is occasionally detected in patients without hepatoma Here, the clinical significance of serum PIVKA‑II levels in patients who were not administered
Honda T, Ichikawa T, Yamashima M, Yamamichi S, Koike M, Nakano Y, Honda T, Yajima H, Miyazaki O, Kuribayashi Y, Ikeda T, Okamura T, Nagata K, Nakao K.   +13 more
europepmc   +3 more sources

Oxylipins‐Omics Combine With Single‐Molecule Analysis Identifies 13(S)‐HODE Positive Extracellular Vesicles as a Diagnostic Biomarker for AFP‐Negative Hepatocellular Carcinoma

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Our work identifies EV‐derived 13(S)‐HODE as a novel biomarker for HCC, establishes a single‐molecule platform for EV lipid analysis, and constructs a high‐performance diagnostic model by integrating multi‐dimensional data, offering new potential strategies for early monitoring and precise diagnosis of HCC.2 ABSTRACT Efficient diagnostic biomarkers ...
Yu Wang, Qiaoting Wu, Huixian Lin, Xiaoqing Jiang, Zhenxun Wang, Chao Yang, Rong Wang, Bo Ma, Yingxue Shen, Jiawei Li, Jiaming Chen, Wanyang Sun, Rongrong He, Lei Zheng, Chunchen Liu, Xin Zhang   +15 more
wiley   +1 more source

Validation of a novel model for the early detection of hepatocellular carcinoma

Clinical Proteomics, 2019
Background The biomarkers alpha-fetoprotein (AFP) and protein induced by vitamin K absence/antagonist-II (PIVKA-II) may be useful for detecting early-stage hepatocellular carcinoma (HCC). We evaluated the performance of AFP and PIVKA-II levels, alone and
Philip M. Hemken, Lori J. Sokoll, Xiaoqing Yang, Jianliang Dai, Debra Elliott, Susan H. Gawel, Michael Lucht, Ziding Feng, Jorge A. Marrero, Sudhir Srivastava, Daniel W. Chan, Gerard J. Davis   +11 more
doaj   +1 more source

A Novel Diagnostic Approach for Hepatocellular Carcinoma Using Glycosylated Ferritin

Hepatology Research, Volume 56, Issue 9, Page 1319-1330, September 2026.
The percentage of glycosylated ferritin relative to total ferritin (%GF) is a novel biomarker for hepatocellular carcinoma (HCC), showing diagnostic performance comparable to that of AFP and DCP. We developed the GFAD index by integrating age, sex, %GF, AFP, and DCP, achieving improved diagnostic accuracy with high sensitivity and specificity. ABSTRACT
Akiyo Ishiguro, Yutaka Suehiro, Issei Saeki, Maho Egusa, Norikazu Tanabe, Toshihiko Matsumoto, Tsuyoshi Ishikawa, Yuki Kunimune, Toshihiko Kobayashi, Mitsuaki Nishioka, Taro Takami, Takahiro Yamasaki   +11 more
wiley   +1 more source

The Malaysian Society of Gastroenterology and Hepatology Consensus Statements on Prevention and Early Detection of Hepatocellular Carcinoma in Malaysia

Journal of Gastroenterology and Hepatology, Volume 41, Issue 9, Page 2639-2655, September 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer‐related deaths in Malaysia. Early detection increases the likelihood of curative treatment and improves survival. This consensus document aims to provide evidence‐based, locally relevant recommendations for the prevention and early detection of HCC.
Su Yin Lau, Victoria Sinq‐Ling Kok, Soek‐Siam Tan, Syuhada Dan Adnan, Wei‐Lin Ng, Ban‐Hong Ang, Nur Yazmin Yaacob, Yeong Yeh Lee, Senamjit Kaur, Rosmawati Mohamed, Ping‐Foo Wong, Lee‐Ling Lim, Mohana Letchumanan, Shireene Ratna Vethakkan, Nurain Mohd Noor, Siow‐Foon Tan, Tiong‐Lim Low, Lee‐Boon Kiew, Wah‐Kheong Chan   +18 more
wiley   +1 more source

Protein Induced by Vitamin K Absence II (PIVKA-II) as a potential serological biomarker in pancreatic cancer: a pilot study [PDF]

, 2019
Introduction: Protein induced by vitamin K absence II (PIVKA-II) is an abnormal prothrombin increased in gastrointestinal malignancy. We aimed to evaluate PIVKA-II in comparison to established pancreatic cancer (PC) biomarkers (CA 19-9, carcinoembryonic ...
Granato, Teresa, Manganaro, Lucia, Irene Pecorella, Cinzia Marchese, Zarrillo, Serena Rita, Valentina Viggiani, Viggiani, Valentina, Marchese, Cinzia, Serena Rita Zarrillo, Lucia Manganaro, Tartaglione, Sara, Pecorella, Irene, Teresa Granato, Antonio Angeloni, Emanuela Anastasi, Angeloni, Antonio, Anastasi, Emanuela, Sara Tartaglione   +17 more
core   +1 more source