Results 61 to 70 of about 5,801,283 (182)

Phase I/II Prospective Study on Endoscopic Ultrasound‐Guided Hepaticogastrostomy as Primary Drainage for Unresectable Malignant Hilar Biliary Obstruction

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Objectives Various drainage methods have been used for unresectable malignant hilar biliary obstruction (MHBO). However, controlling cholangitis and obstructive jaundice is still challenging. We performed a phase I/II study of endoscopic ultrasound‐guided hepaticogastrostomy (EUS‐HGS) as primary drainage for MHBO.
Tomoki Ogata, Kazuo Hara, Nozomi Okuno, Shin Haba, Takamichi Kuwahara, Shimpei Matsumoto, Hiroki Koda, Keigo Oshiro   +7 more
wiley   +1 more source

Diagnostic Performance of Extrahepatic Protein Induced by Vitamin K Absence in the Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

Diagnostics, 2023
Background and Objectives: the early diagnosis of hepatocellular carcinoma (HCC) benefits from the use of alpha-fetoprotein (AFP) together with imaging diagnosis using abdominal ultrasonography, CT, and MRI, leading to improved early detection of HCC.
Mirela Georgiana Perne, Adela-Viviana Sitar-Tăut, Teodora Gabriela Alexescu, Lorena Ciumărnean, Mircea-Vasile Milaciu, Sorina-Cezara Coste, Calin-Vasile Vlad, Angela Cozma, Dan-Andrei Sitar-Tăut, Olga Hilda Orăşan, Alexandra Crăciun   +10 more
doaj   +1 more source

Combined PIVKA II and Vimentin-Guided EMT Tracking in Pancreatic Adenocarcinoma Combined Biomarker-Guided EMT Tracking in PDAC. [PDF]

Cancers (Basel)
Simple Summary Protein Induced by Vitamin K Absence (PIVKA II), also known as Des-gamma-Carboxy prothrombin (DCP), is an established tumor marker for hepatocellular carcinoma (HCC) and a good diagnostic performance has also been demonstrated for ...
Farina A, Viggiani V, Cortese F, Moretti M, Tartaglione S, Angeloni A, Anastasi E.   +6 more
europepmc   +2 more sources

Comparative Diagnostic Sensitivity of Endoscopic Ultrasound‐guided Tissue Acquisition for Hepatocellular Carcinoma Versus Intrahepatic Cholangiocarcinoma

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Background and Aims Accurate histological differentiation between hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) is essential for selecting appropriate treatment. Endoscopic ultrasound‐guided tissue acquisition (EUS‐TA) is increasingly used for focal liver lesions; however, comparative data on its diagnostic ...
Yuichi Takano, Naoki Tamai, Jun Noda, Tetsushi Azami, Fumitaka Niiya, Ryo Uyama, Naotaka Maruoka, Tatsuya Yamagami, Akihiro Nakamura, Takafumi Ogawa, Takahiro Umemoto, Masatsugu Nagahama   +11 more
wiley   +1 more source

Bayesian Power‐Based Sample Size Determination for Diagnostic Accuracy Studies

Pharmaceutical Statistics, Volume 25, Issue 6, November/December 2026.
ABSTRACT In diagnostic accuracy studies, it is crucial to estimate the required sample size beforehand for the appropriate evaluation of diagnostic measures (e.g., sensitivity and/or specificity). In the development of pharmaceuticals and medical devices, although frequentist approaches have been used for sample size determination, Bayesian approaches ...
Shunsuke Shiota, Go Horiguchi, Akari Naito, Mitsuko Nakata, Satoshi Teramukai   +4 more
wiley   +1 more source

Usefulness of PIVKA-II for diagnosis and evaluation of recurrence of hepatocellular carcinoma [PDF]

, 2017
Backgroud: Although alpha-fetoprotein (AFP) is most widely used tumor marker for hepatocellular carcinoma (HCC), the sensitivity is about 60~70% in advanced HCC. Furthermore, the specificity of AFP is relatively low. The aim of this study was to evaluate
안상훈, 이관식, 심명기, 김도영, 한광협, 김자경, 전재윤, 김경규, 백용한   +8 more
core  

PIVKA-II Is a Useful Tumor Marker for Recurrent Hepatocellular Carcinoma after Surgical Resection

, 2007
OBJECTIVES: The aim of this study is to assess the usefulness of prothrombin induced by vitamin K absence or antagonist-II (PIVKA-II) in monitoring of recurrent hepatocellular carcinoma (HCC) after curative resection.
안상훈, 이관식, 윤영준, 김도영, 한광협, 김자경, 전재윤, 최종원, 백용한   +8 more
core   +1 more source

Diagnostic Performance of AFP, AFP-L3, or PIVKA-II for Hepatitis C Virus-Associated Hepatocellular Carcinoma: A Multicenter Analysis

, 2022
Background and Aim: Alpha-fetoprotein (AFP), a lens culinaris agglutinin-reactive fraction of AFP (AFP-L3), is a protein that is induced by vitamin K deficiency or antagonist-II (PIVKA-II) that has been clinically used as a serum biomarker for early ...
Siyu Liu, Feng Shen, Guan, Mingcheng, Pawlik, Timothy M., Xu, Min, Zhu, Hong, Timothy M. Pawlik, Yang, Tian, Liyang Sun, Yongkang Diao, Tian Yang, Hao Xing, Min Xu, Lanqing Yao, Mingda Wang, Liu, Siyu, Xiangmin Tong, Wan Yee Lau, Yao, Lanqing, Tong, Xiangmin, Lau, Wan Yee, Wang, Mingda, Shen, Feng, Xing, Hao, Sun, Liyang, Diao, Yongkang, Mingcheng Guan, Hong Zhu   +27 more
core   +1 more source

Impact of PD‐1 Inhibitor Timing Relative to Locoregional Therapy on Outcomes in uHCC Treated With Lenvatinib‐Based Triple Therapy

Liver International, Volume 46, Issue 10, October 2026.
ABSTRACT Background and Aims The optimal sequencing of programmed cell death protein 1 (PD‐1) inhibitors relative to locoregional therapy (LRT) in unresectable hepatocellular carcinoma (uHCC) remains undefined. This study evaluated the impact of PD‐1 inhibitor timing on outcomes in patients receiving hepatic arterial infusion chemotherapy (HAIC) or ...
Jian He, Jian Chen, Bohua Yu, Fuqun Wei, Weifu Liu, Peishu Huang, Songhui Wu, Xiang You, Zhisheng Chen, Ziqi Lin, Wuhua Guo, Shaowu Zhuang, Yiping Chen, Zhongwu Chen   +13 more
wiley   +1 more source

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source