Results 31 to 40 of about 18,309 (196)

State of emergency care in Slovakia: a scoping review

International Journal of Emergency Medicine
Background and aim The current evidence regarding the state and evolution of emergency care (EC) in Slovakia, including the needs of both patients and healthcare personnel, remains poorly understood.
Vladimira Timkova, Pavol Mikula, Zuzana Katreniakova, Lukas Olsavsky, Iveta Nagyova   +4 more
doaj   +1 more source

Dominant Species Composition, Environmental Characteristics and Dynamics of Forests with Picea jezoensis Trees in Northeast China

Diversity
To describe the characteristics and dynamics of the Picea jezoensis (PJ) community, a survey of 48 forest plots containing PJ trees was conducted in Northeast China.
Jichen Duan, Zhiyuan Jia, Shusen Ge, Yutang Li, Dongwei Kang, Junqing Li   +5 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Protective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats [PDF]

International Journal of Ophthalmology, 2017
AIM: To investigate the effect of pomegranate juice (PJ) intake on overall oxidation status in retinas of diabetic rats. METHODS: Twenty-seven rats were divided into four groups as control (CO), diabetic (DM), control treated with PJ (CO-PJ), and ...
Betul Tugcu, Senay Asik Nacaroglu, Asuman Gedikbasi, Mehmet Uhri, Nur Acar, Hakan Ozdemir   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Epidemiology of Primary Biliary Cholangitis in European Countries: A Systematic Review and Meta-Analysis

Canadian Journal of Gastroenterology and Hepatology, 2021
Background. Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease with wide ranges of reported incidence and prevalence. Aim. To map the incidence and prevalence of PBC in European countries from 2000 through 2020.
Jakub Gazda, Sylvia Drazilova, Martin Janicko, Peter Jarcuska   +3 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

POMEGRANATE JUICE TREATMENT PREVENTS CARBON TETRACHLORIDE(CCL4)-INDUCED TESTICULAR DAMAGE IN RATS: A BIOCHEMICAL AND HISTOLOGICAL STUDY

Slovenian Veterinary Research
We investigated the side effects of carbon tetrachloride (CCl4) on testicular tissue and explored the protective effects of pomegranate juice (PJ) against CCl4 exposure.
Ömer Faruk Kalkan, Ahmet Türk, Cihan Çitil, Miraç Uçkun, Ahmet Özkaya, Ertan Yoloğlu, Yusuf Özay, Şeyda Çağri Bülbül, Nadir Bilgin Akgül, Zafer Şahin, Akın Kirbaş   +10 more
doaj   +1 more source

Pomegranate Juice Supplementation Alters Utero-Placental Vascular Function and Fetal Growth in the eNOS−/− Mouse Model of Fetal Growth Restriction

Frontiers in Physiology, 2018
The eNOS−/− mouse provides a well-characterized model of fetal growth restriction (FGR) with altered uterine and umbilical artery function and reduced utero- and feto-placental blood flow.
Sarah L. Finn-Sell, Sarah L. Finn-Sell, Elizabeth C. Cottrell, Elizabeth C. Cottrell, Susan L. Greenwood, Susan L. Greenwood, Mark R. Dilworth, Mark R. Dilworth, Elizabeth J. Cowley, Elizabeth J. Cowley, Colin P. Sibley, Colin P. Sibley, Mark Wareing, Mark Wareing   +13 more
doaj   +1 more source