Results 191 to 200 of about 320,211 (227)

Signaling architecture of the glucagon-like peptide-1 receptor. [PDF]

J Clin Invest
Austin G, Tomas A.
europepmc   +1 more source

Operational stability of mixed Sn–Pb perovskite solar cells: Mechanisms, mitigation strategies, and perspectives

Bulletin of the Korean Chemical Society, EarlyView.
This review consolidates mechanisms and solutions for mixed Sn–Pb perovskite solar cells. It identifies Sn2+ oxidation, iodine generation, and interfacial defects as primary instabilities. It discusses progress in additives, interface passivation, alternative hole transport layers, and solvent engineering as well as future directions for achieving long‐
Lei Chen, Kai Zhu
wiley   +1 more source

cAMP-PKA/EPAC signaling pathways: crucial regulators of lipid homeostasis. [PDF]

Adipocyte
Chen C, Gao H, Tian Q, Cao J.
europepmc   +1 more source

Understanding cationic polyelectrolyte thermogels with varying charge densities toward biomaterials design

BMEMat, EarlyView.
Cationic polyurethane thermogels with customizable charge density were developed, exhibiting enhanced pH‐responsiveness. This work elucidates how cationic charges influence self‐assembly and thermogelling, providing insights for designing smart biomaterials.
Belynn Sim, Yi Jing Wong, Hamzah Kamaruddin, Qianyu Lin, Pablo Mota‐Santiago, Nigel Kirby, Alexis Lee, Yihao Leow, Alice Anhan Chen, Rubayn Goh, Xian Jun Loh   +10 more
wiley   +1 more source

Protein kinase a regulates cyclooxygenase-2 expression through the RNA-binding proteins HuR and TTP. [PDF]

J Biol Chem
Adame-Garcia SR, Hoang TS, Tien Vo PT, Burghi V, Cervantes-Villagrana RD, Orduña-Castillo LB, Ramms DJ, Trejo J, Gutkind JS.   +8 more
europepmc   +1 more source

Eudragit®‐engineered pH‐responsive probiotic microspheres with enhanced gastrointestinal resistance and prolonged storage stability for inflammatory bowel disease therapy

BMEMat, EarlyView.
This study reports the development of AMS@Eud core‐shell microspheres, combining calcium alginate and pH‐responsive Eudragit® L100, which exhibit exceptional gastrointestinal resistance and long‐term storage stability (only 5.28%–9.09% viability loss over 35 days at 4–25°C), and effectively alleviate inflammatory bowel disease via gut microbiota ...
Ming Teng, Xiaomin Luo, Peng Zhang, Chen Yang, Yuniel Ma, Xinhua Liu   +5 more
wiley   +1 more source

Lgmn targets two distinct GPCRs, PAR2 and µ-OR1, and induces cell death in acute lymphoblastic leukemia through an intracellular Ca²⁺ imbalance triggered by ER Ca²⁺ release. [PDF]

Cell Death Discov
Lee JK, Riabowol K, Lee KY.
europepmc   +1 more source

Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia

BMEMat, EarlyView.
CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai, Rui Zhang, Haiyin Yang, Jiyue Xing, Tianyuan Hu, Mengxi Zhu, Rui Li, Xiaoli Chen, Beibei Zhao, Yang Lan, Stefan Barth, Yuanyu Huang, Li Zhang, Mengjie Zhang, Huining He   +14 more
wiley   +1 more source

Protein Kinase A Signaling in Cortisol Production and Adrenal Cushing's Syndrome. [PDF]

Cells
Kumar A, Sharma A, Omar MH.
europepmc   +1 more source