Results 81 to 90 of about 95,096 (261)

Real‐World Patterns of Botulinum Toxin Treatment in Hyperkinetic Movement Disorders: A 9‐Year Nationwide Analysis in France

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Hyperkinetic movement disorders, including dystonia, tremor, and myoclonus, are disabling conditions often managed with botulinum toxin type A (BoNT‐A). Real‐world evidence on treatment patterns remains limited. Objective This nationwide, population‐based study aimed to evaluate trends in BoNT‐A use in France between 2015 and 2023 ...
Marion Simonetta‐Moreau, Pierre Karam, Anne Forestier, Bertrand Degos   +3 more
wiley   +1 more source

The Predictive Value of PKC and ET-1 Levels in Cerebrospinal Fluid for Vasospasm and Prognosis in Patients with Aneurysmal Subarachnoid Hemorrhage

International Journal of General Medicine
Hailong Li, Donghua Li, Mi Li, Zehong Hu Department of Neurosurgery, Panzhihua Central Hospital, Panzhihua City, Sichuan Province, People’s Republic of ChinaCorrespondence: Hailong Li, Department of Neurosurgery, Panzhihua Central Hospital, No.
Li H, Li D, Li M, Hu Z
doaj  

PKC and calcium channel trafficking [PDF]

Channels, 2017
The L-type calcium channel (Cav1.2) regulates cardiac contraction and is modulated by different hormones and neurotransmitter via G-proteins and protein kinases.
openaire   +2 more sources

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 production

Scientific Reports, 2017
HIV-1 Tat protein induces the production of CXCL8 chemokine in a TLR4/MD2 and PKC dependent manner. The objective of this study was to understand whether these two pathways were distinct or constituted a single common pathway, and to determine the nature
Manutea Serrero, Rémi Planès, Elmostafa Bahraoui   +2 more
doaj   +1 more source

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source

Broiler chickens’ responses to a diet incorporating fermented or unfermented palm kernel cake on intestinal morphology, antioxidant indices, caecal microbiota composition, and liver metabolomic profiles

Italian Journal of Animal Science
This study evaluated the effect of feeding broiler chickens a diet incorporating fermented or unfermented palm kernel cake (PKC) on their intestinal morphology, antioxidant indices, caecal microbiota composition, short-chain fatty acids, and liver ...
Sindaye Daniel, Shehata Zeid, Liao Jinghong, Suqin Hang   +3 more
doaj   +1 more source

Down-Regulation of Protein Kinase C-ε by Prolonged Incubation with PMA Inhibits the Proliferation of Vascular Smooth Muscle Cells

Cellular Physiology and Biochemistry, 2016
Background/Aims: Phorbol myristate acetate (PMA) exerts a pleiotropic effect on the growth and differentiation of various cells. Protein kinase Cs (PKCs) plays a central role in mediating the effects of PMA on cells.
Huixuan Zhou, Yan Wang, Quanhong Zhou, Bin Wu, Aizhong Wang, Wei Jiang, Li Wang   +6 more
doaj   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

Respon Kecernaan Bahan Kering dan Ukuran Tubuh Kambing Peranakan Etawah Jantan Terhadap Pemberian Bungkil Inti Sawit

Jurnal Agripet, 2016
. A Study on dry matter digestibility and body sizes of Peranakan Etawah  male goat given palm kernel cake (PKC) condukted at the experimental farm of Agriculture Fakulty of Syiah Kuala University.
Asril Asril
doaj   +1 more source