Results 71 to 80 of about 97,124 (258)

The signal transduction pathway of PKC/NF-κB/c-fos may be involved in the influence of high glucose on the cardiomyocytes of neonatal rats

Cardiovascular Diabetology, 2009
Background High glucose could induce structure and function change in cardiomyocytes, PKC plays a core effect in the onset and progression of diabetic cardiomyopathy, but its underlying downstream signal transduction pathway is still not completely ...
Hui Zhu, Quan Zhou, Bin Zhang, Min Wang, Sheng Fu   +4 more
doaj   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Real‐World Patterns of Botulinum Toxin Treatment in Hyperkinetic Movement Disorders: A 9‐Year Nationwide Analysis in France

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Hyperkinetic movement disorders, including dystonia, tremor, and myoclonus, are disabling conditions often managed with botulinum toxin type A (BoNT‐A). Real‐world evidence on treatment patterns remains limited. Objective This nationwide, population‐based study aimed to evaluate trends in BoNT‐A use in France between 2015 and 2023 ...
Marion Simonetta‐Moreau, Pierre Karam, Anne Forestier, Bertrand Degos   +3 more
wiley   +1 more source

Targeting PKC theta in alloreactivity and graft-versus-host-disease: unanswered questions and therapeutic potential

Frontiers in Immunology, 2012
Protein kinase C isoform theta (PKC theta) is a key modulator of TCR signaling and mediates activation of NF-kappaB, NF-AT and AP-1 transcription factors.
Crystina eBronk, Xue-Zhong eYu, Amer eBeg   +2 more
doaj   +1 more source

Side Channels in the McEliece PKC [PDF]

, 2008
The McEliece public key cryptosystem (PKC) is regarded as secure in the presence of quantum computers because no efficient quantum algorithm is known for the underlying problems, which this cryptosystem is built upon. As we show in this paper, a straightforward implementation of this system may feature several side channels.
Falko Strenzke, Erik Tews, H. Gregor Molter, Raphael Overbeck, Abdulhadi Shoufan   +4 more
openaire   +2 more sources

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

Aldosterone rapidly activates p-PKC delta and GPR30 but suppresses p-PKC epsilon protein levels in rat kidney

Endocrine Regulations, 2019
Objectives. Aldosterone rapidly enhances protein kinase C (PKC) alpha and beta1 proteins in the rat kidney. The G protein-coupled receptor 30 (GPR30)-mediated PKC pathway is involved in the inhibition of the potassium channel in HEK-239 cells.
Eiam-Ong Somchit, Chaipipat Mookda, Manotham Krissanapong, Eiam-Ong Somchai   +3 more
doaj   +1 more source

Analysis of PKC targeting mechanism using PKC fused with fluorescent proteins.

Folia Pharmacologica Japonica, 2003
Protein kinase C (PKC) is a family, which consists of at least ten subtypes. To elucidate subtype-specific functions of PKC, we have developed the methods to observe PKC translocation in real time and in the living state using PKC fused with fluorescent proteins, including GFP and DsRed.
SAKAI, Norio, SHIRAI, Yasuhito, SAITO, Naoaki   +2 more
openaire   +3 more sources

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

The Predictive Value of PKC and ET-1 Levels in Cerebrospinal Fluid for Vasospasm and Prognosis in Patients with Aneurysmal Subarachnoid Hemorrhage

International Journal of General Medicine
Hailong Li, Donghua Li, Mi Li, Zehong Hu Department of Neurosurgery, Panzhihua Central Hospital, Panzhihua City, Sichuan Province, People’s Republic of ChinaCorrespondence: Hailong Li, Department of Neurosurgery, Panzhihua Central Hospital, No.
Li H, Li D, Li M, Hu Z
doaj