Results 31 to 40 of about 65,702 (193)

Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A

Frontiers in Physiology, 2020
The protein kinase enzyme family plays a pivotal role in almost every aspect of cellular function, including cellular metabolism, division, proliferation, transcription, movement, and survival.
Chong Liu, Ping Ke, Jingjing Zhang, Xiaoying Zhang, Xiongwen Chen   +4 more
doaj   +1 more source

EKSISTENSI LEKRA DALAM PUSARAN MANIFESTO KEBUDAYAAN DEMOKRASI TERPIMPIN

Istoria, 2022
Demokrasi Terpimpin merupakan sistem demokrasi yang berlangsung setelah Dekrit Presiden 5 Juli 1959. Diterapkannya sistem ini menyebabkan kekuasaan Soekarno bersifat mutlak, karena segala keputusan berada di tangan presiden.
Cici Widariyanti
doaj   +1 more source

Graphene‐Enhanced Plasmonic Interfaces: A General Strategy for Highly Sensitive Detection of Biomolecular Interactions

Advanced Healthcare Materials, EarlyView.
Monolayer graphene coating significantly enhances the sensing performance of conventional SPR biosensors. Its impact is evaluated using biologically relevant models, including antibody‐virus and peptide‐cell interactions. Graphene‐enhanced SPR enabled specific virus detection via antibodies and effective cell type discrimination using synthetic ...
Ahmar Hasnain, Heiko Heilmann, Nghi Luong Phuong Le, Klaus‐Ingmar Pfrepper, Andreas Wruck, Peter Groß, Bernd Bufe, Alexey Tarasov   +7 more
wiley   +1 more source

Human vs. artificial intelligence: Physicians outperform ChatGPT in real‐world pharmacotherapy counselling

British Journal of Clinical Pharmacology, EarlyView.
Aims To assess the utility of the artificial intelligence (AI) chatbot ChatGPT (openly available version 3.5) in responding to real‐world pharmacotherapeutic queries from healthcare professionals. Methods Three independent and blinded evaluators with different levels of medical expertise and professional experience (beginner, advanced, and expert ...
Benjamin Krichevsky, Stefan Engeli, Stefanie M. Bode‐Böger, Felix Koop, Martin Schulze Westhoff, Sebastian Schröder, Carsten Schumacher, Thorben Pape, Dirk O. Stichtenoth, Johannes Heck   +9 more
wiley   +1 more source

Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization

Medicinal Research Reviews, EarlyView.
ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg, Tracie Widjaja, Adriaan P. IJzerman, Daan van der Es   +3 more
wiley   +1 more source

Molecular Recognition of FDA-Approved Small Molecule Protein Kinase Drugs in Protein Kinases

Molecules, 2022
Protein kinases are key enzymes that catalyze the covalent phosphorylation of substrates via the transfer of the γ-phosphate of ATP, playing a crucial role in cellular proliferation, differentiation, and various cell regulatory processes.
Yan Zhu, Xiche Hu
doaj   +1 more source

Secure agent data integrity shield [PDF]

, 2004
In the rapidly expanding field of E-Commerce, mobile agent is the emerging technology that addresses the requirement of intelligent filtering/processing of information. This paper will address the area of mobile agent data integrity protection.
Borselius, Borselius, Guan, Guan, Guan, Johansen, Ng, Park, Patrick, Schneier, Sheng-Uei Guan, Tripathi, Wang, Yang, Yang Yang, Zhu   +15 more
core   +1 more source

Structure‐Guided Identification and Evaluation of Epalrestat and Ranirestat‐Like Compounds Against Aldose Reductase: Therapeutic Management of Diabetic Neuropathy

ChemistryOpen, EarlyView.
Structure‐based virtual screening of PubChem compounds identifies two novel epalrestat and ranirestat‐like inhibitors with improved affinity and pharmacokinetic profiles targeting aldose reductase. Molecular docking, ADMET filtering, and 500‐ns molecular dynamics simulations confirm the stability and interaction specificity of the candidates ...
Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Anas Shamsi   +3 more
wiley   +1 more source

Anonymous Single-Sign-On for n designated services with traceability [PDF]

, 2018
Anonymous Single-Sign-On authentication schemes have been proposed to allow users to access a service protected by a verifier without revealing their identity which has become more important due to the introduction of strong privacy regulations.
CI Fan, CP Schnor, D Boneh, D Boneh, D Boneh, D Boneh, D Chaum, DM Gordon, E Ghadafi, F Armknecht, I Teranishi, J Camenisch, J Camenisch, J Camenisch, J Camenisch, J Camenisch, J Camenisch, J Han, K Elmufti, L Nguyen, M Bellare, M Jakobsson, MH Au, SD Galbraith, TF Lee, W Diffie, W Liu   +26 more
core   +2 more sources

Multi‐Timescale Scenario‐Driven Hierarchical Capacity Configuration of Integrated Energy Systems via Multi‐Source Data Fusion

IET Smart Energy Systems, EarlyView.
This paper proposes a multi‐timescale scenario‐driven hierarchical configuration framework that employs multi‐source data fusion to enhance data quality, extract joint features and generate representative scenarios for system optimisation. Results indicate that the proposed approach significantly improves economic efficiency, environmental performance ...
Yunzhi Li, Jizhen Liu, Yang Sun, Yang Hu, Ming Li   +4 more
wiley   +1 more source