Results 41 to 50 of about 21,725 (207)
Molecular Recognition of FDA-Approved Small Molecule Protein Kinase Drugs in Protein Kinases
Protein kinases are key enzymes that catalyze the covalent phosphorylation of substrates via the transfer of the γ-phosphate of ATP, playing a crucial role in cellular proliferation, differentiation, and various cell regulatory processes.
Yan Zhu, Xiche Hu
doaj +1 more source
Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction
Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan +17 more
wiley +1 more source
This paper provides a review of the current state of the art in standards for Public Key Infrastructures. The main focus of the paper is the recent work by the Internet Engineering Task Force, ITU-T, and ISO/IEC.
openaire +6 more sources
Aims To assess the utility of the artificial intelligence (AI) chatbot ChatGPT (openly available version 3.5) in responding to real‐world pharmacotherapeutic queries from healthcare professionals. Methods Three independent and blinded evaluators with different levels of medical expertise and professional experience (beginner, advanced, and expert ...
Benjamin Krichevsky +9 more
wiley +1 more source
Pada akhir abad ke-19 paham liberalisme ekonomi ala Barat terdengar gaungnya oleh pemerinah Hindia-Belanda. Paham itu mengubah kebijakan ekonomi pemerintah dari yang semula kerja paksa menjadi industrialisasi.
Ahmad Syatori
doaj
Targeting Autophagy in Ovarian Cancer: The Emerging Role of Ginsenosides
ABSTRACT Background Ovarian cancer, the third most prevalent gynecological malignancy, is frequently diagnosed at an advanced stage owing to its asymptomatic early progression. Despite the application of conventional therapies, clinical management remains limited by adverse effects and the development of drug resistance.
Yuxin Guo +4 more
wiley +1 more source
We’ve had problems in the past with internal compromises, and management has decided that the only way to protect the information is to encrypt it during transmission.
openaire +1 more source
TLS/PKI Challenges and Certificate Pinning Techniques for IoT and M2M Secure Communications
Transport layer security (TLS) is becoming the de facto standard to provide end-to-end security in the current Internet. IoT and M2M scenarios are not an exception since TLS is also being adopted there.
Daniel Díaz Sánchez +4 more
semanticscholar +1 more source
Upstream CB1R Regulation of β‐Adrenergic Memory Consolidation
ABSTRACT Object recognition memory (ORM) plays a key role in identifying familiar items and encoding episodic information. ORM consolidation depends on β‐adrenergic receptor (βAR) signaling and is associated with increased BDNF expression in the dorsal hippocampus.
Janine I. Rossato +9 more
wiley +1 more source
A Semi-Decentralized PKI Based on Blockchain With a Stake-Based Reward-Punishment Mechanism
The conventional Public Key Infrastructure (PKI) has long been plagued by security issues stemming from its centralized and non-transparent design. In recent years, blockchain-based PKI architectures have emerged as promising solutions to overcome such ...
Erhan Turan, Sevil Sen, Tamer Ergun
doaj +1 more source

