Results 61 to 70 of about 65,702 (193)

ATP mediates both activation and inhibition of K(ATP) channel activity via cAMP-dependent protein kinase in insulin-secreting cell lines. [PDF]

open access: yes, 1989
The single-channel recording technique was employed to investigate the mechanism conferring ATP sensitivity to a metabolite-sensitive K channel in insulin-secreting cells.
Ciani, S, Eddlestone, GT, Ribalet, B
core  

Population Pharmacokinetic and Pharmacokinetic‐Pharmacodynamic Analysis for Clazakizumab in Patients With End‐Stage Kidney Disease Undergoing Dialysis

open access: yesClinical and Translational Science, Volume 18, Issue 11, November 2025.
ABSTRACT The inflammatory cytokine interleukin‐6 (IL‐6) plays a significant role in the progression of cardiovascular disease (CVD). We evaluated the impact of clazakizumab, a monoclonal antibody targeting the IL‐6 ligand, upon high‐sensitivity C‐reactive protein (hs‐CRP) as part of the dose‐finding phase 2b trial.
Venkateswari Y. Muthukrishnan   +8 more
wiley   +1 more source

Identification of Toxoplasma gondii cAMP dependent protein kinase and its role in the tachyzoite growth. [PDF]

open access: yesPLoS ONE, 2011
cAMP-dependent protein kinase (PKA) has been implicated in the asexual stage of the Toxoplasma gondii life cycle through assaying the effect of a PKA-specific inhibitor on its growth rate. Since inhibition of the host cell PKA cannot be ruled out, a more
Hitomi Kurokawa   +10 more
doaj   +1 more source

Pendekatan konstruktif dalam inovasi pengajaran dan pembelajaran Bahasa Melayu di Kolej Vokasional [PDF]

open access: yes, 2008
Pendekatan konstruktif adalah pendekatan pengajaran dan pembelajaran yang berpusatkan pelajar manakala inovasi pengajaran pula dikaitkan dengan kaedah pengajaran yang terbaru demi mengukuhkan pemahaman pelajar.
Omar, Zakaria
core  

A flexible, allosteric loop regulates protein activity and rewires electrostatics

open access: yesProtein Science, Volume 34, Issue 10, October 2025.
Abstract Allostery is a key driver of protein function and behavior in biological systems. Historically, allosteric regulation has been attributed to conformational and dynamic changes, mostly derived from well‐structured regions of proteins. While the regulatory contributions of specific unstructured elements, such as catalytic loops near the active ...
Darex J. Vera‐Rodríguez   +3 more
wiley   +1 more source

Optimizing image capture for computer vision‐powered taxonomic identification and trait recognition of biodiversity specimens

open access: yesMethods in Ecology and Evolution, Volume 16, Issue 10, Page 2260-2275, October 2025.
Abstract Biological collections house millions of specimens with digital images increasingly available through open‐access platforms. However, most imaging protocols were developed for human interpretation without considering automated analysis requirements.
Alyson East   +27 more
wiley   +1 more source

POSTMEMORY DALAM NOVEL TAPOL KARYA NGARTO FEBRUANA

open access: yesJurnal Poetika, 2019
Narasi balas dendam yang masih terus direproduksi oleh pihak-pihak yang bertikai semakin membuat rekonsiliasi tragedi ’65 berujung pada kemacetan. Kerelaan untuk sa-ling mengakui kesalahan adalah langkah besar dalam usaha rekonsiliasi.
Anna Elfira Prabandari Assa
doaj   +1 more source

The persistence and expansion of sharecropping in a Javanese village

open access: yesJournal of Agrarian Change, Volume 25, Issue 4, October 2025.
Abstract In the Javanese village of Kaliloro, share tenancy in rice cultivation, which was widely predicted to disappear with the Green Revolution, has not declined but expanded since the early 1970s. In this article, building on previous debates on share tenancy, we show how sharecropping has survived and expanded in Kaliloro's generally commoditized ...
Hanny Wijaya, Ben White
wiley   +1 more source

Debridement, antibiotics, and implant retention for periprosthetic knee infections: a pooling analysis of 1266 cases

open access: yesJournal of Orthopaedic Surgery and Research, 2019
Background The debridement, antibiotics, and implant retention (DAIR) procedure is an established therapeutic option for periprosthetic knee infections (PKI). However, the efficacy and the indication for this procedure are still controversial.
Guo-Xin Qu   +3 more
doaj   +1 more source

Understanding preference formation in a matching market [PDF]

open access: yes, 2001
We analyze the role of formal and informal information gathering in students' preference formation. We analyzed this role in the college admission process using Spanish individual data.
Mora, Ricardo, Romero-Medina, Antonio
core   +2 more sources

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