Results 111 to 120 of about 16,547 (202)

Exploring the Role of Long Noncoding RNAs in Breast Cancer Progression: A Comprehensive Study on Biomarkers and Therapeutic Approaches

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Among the many forms of cancer that plague women all over the globe, breast cancer (BC) is one of the most prevalent kinds. BC is a multifaceted disease that can manifest in many ways depending on the individual. Aims The identification of new biomarkers that may be used to diagnose and prognosis of the BC, as well as those that can
Ramin Moeini, Amin AhsanAlkhat, Saeid Ghorbian   +2 more
wiley   +1 more source

BRG1 inhibits glycolysis by promoting SHP1-mediated dephosphorylation of PKM2 in non-small cell lung cancer [PDF]

Wenli Zhan, Haokun Zhang, Xiaowei She, Genshan Zhang, Jiakun Zhang, Xuelai Luo, Haijie Li, Jingqin Lan   +7 more
openalex   +1 more source

<p>Experimental Study of Hepatocellular Carcinoma Treatment by Shikonin Through Regulating PKM2</p>

, 2020
Tong Liu, Sainan Li, Liwei Wu, Qiang Yu, Jingjing Li, Jiao Feng, Jie Zhang, Jiaojiao Chen, Yuting Zhou, Jie Ji, Kan Chen, Yuqing Mao, Fan Wang, Weiqi Dai, Xiaoming Fan, Jianye Wu, Chuanyong Guo   +16 more
openalex   +2 more sources

Mechanistic Insights and Therapeutic Potential of Small Nucleolar RNA Host Genes in the Carcinogenesis of Hepatocellular Carcinoma

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) is one of the major factors endangering human health due to its poor prognosis, resulting from difficulties in early diagnosis and lack of effective treatment measures. Long non‐coding RNAs (lncRNAs), which are RNA molecules that do not translate into proteins, play essential roles in various tumor ...
Jiajia Luo, Zhangxiu Liao, Shuangxia Zhang   +2 more
wiley   +1 more source

Secreted parasite Pin1 isomerase stabilizes host PKM2 to reprogram host cell metabolism [PDF]

, 2019
Justine Marsolier, Martine Perichon, Jonathan B Weitzman, Souhila Medjkane   +3 more
openalex   +1 more source

Figure S3 from Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities

, 2023
Andrés Méndez‐Lucas, Xiaolei Li, Junjie Hu, Li Che, Xinhua Song, Jiaoyuan Jia, Jingxiao Wang, Chencheng Xie, Paul C. Driscoll, Darjus F. Tschaharganeh, Diego F. Calvisi, Mariia Yuneva, Xin Chen   +12 more
openalex   +1 more source

CXCL10high Microglia in Cerebral Malaria: Toward Translational Validation

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
ABSTRACT Wang et al. identify CXCL10high TNFαhigh Ki67+ microglia as drivers of CD8+ T cell recruitment during experimental cerebral malaria (ECM). We propose a conservative reframing: rather than asserting a fully validated new taxonomy, CXCL10high microglia should be considered a candidate “neuroimmune endotype” whose translational relevance requires
Nathkapach K. Rattanapitoon, Chadaporn N. Gordon, Natthawut Charoenphon, Schawanya K. Rattanapitoon   +3 more
wiley   +1 more source

PKM2 regulates metabolic flux and oxidative stress in the murine heart

Physiological Reports
Cardiac metabolism ensures a continuous ATP supply, primarily using fatty acids in a healthy state and favoring glucose in pathological conditions. Pyruvate kinase muscle (PKM) controls the final step of glycolysis, with PKM1 being the main isoform in ...
Katie C. Y. Lee, Allison L. Williams, Lu Wang, Guoxiang Xie, Wei Jia, Anastasia Fujimoto, Mariana Gerschenson, Ralph V. Shohet   +7 more
doaj   +1 more source

[Corrigendum] MicroRNA‑122 affects cell aggressiveness and apoptosis by targeting PKM2 in human hepatocellular carcinoma

, 2021
Qiuran Xu, Meiqi Zhang, Jian‐Feng Tu, Linxiao Pang, Wenwei Cai, Xin Liu   +5 more
openalex   +2 more sources

Feedback regulation between histone H3 lysine 18 lactylation and TROP2‐mediated glycolysis drives metastatic progression of colorectal cancer

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
TROP2 is upregulated in CRC metastasis and promotes lactate overproduction via YBX1‐HIF‐1α signalling. TROP2 signalling induces H3K18la at metastasis genes promoters in CRC and promotes their expression. AccLactate sustains TROP2 expression in CRC cells via H3K18la Acriflavine suppresses TROP2‐driven CRLM by targeting the H3K18la/TROP2 feedback loop ...
Weifeng Wang, Yuxiang Deng, Weihao Li, Ruowei Wang, Chi Zhou, Yanbo Xu, Jiahua He, Le' en Liao, Jin Lan, Long Yu, Da Kang, Weili Zhang, Qingjian Ou, Zhizhong Pan, Yujing Fang, Peirong Ding, Junzhong Lin, Jianhong Peng   +17 more
wiley   +1 more source