Results 181 to 190 of about 24,169 (302)

CircRNA-0013747 Promotes Mesangial Cell Proliferation in Immunoglobulin A Nephropathy through Modulation of the Warburg Effect

Journal of Physiological Investigation
Immunoglobulin A nephropathy (IgAN) is characterized by aberrant mesangial cell (MC) proliferation, which is a critical determinant of glomerular sclerosis and renal dysfunction.
Huimei Zou, Wenli Deng, Lifen Xu, Mingjun Shi, Lingling Liu, Lei Gong, Daolin Cui, Fan Zhang   +7 more
doaj   +1 more source

NMR‐based metabolomics combined with metabolic pathway analysis reveals metabolic heterogeneity of colorectal cancer tissue at different anatomical locations and stages

International Journal of Cancer, Volume 156, Issue 8, Page 1644-1655, 15 April 2025.
What's new? Current screening tests for colorectal cancer (CRC) include colonoscopy and fecal occult blood test, both of which have significant drawbacks. Here, the authors tested NMR‐based metabolomic fingerprinting as a potential CRC screening technique.
Rongzhi Cai, LiXin Ke, Yan Zhao, Jiayun Zhao, Huanian Zhang, Peie Zheng, Lijing Xin, Changchun Ma, Yan Lin   +8 more
wiley   +1 more source

Impact of butyrate on PKM2 and HSP90β expression in human colon tissues of different transformation stages: a comparison of gene and protein data [PDF]

, 2011
Franziska Jahns, Anne Wilhelm, Karl Otto Greulich, Henning Mothes, Mariya Y. Radeva, Anja Wölfert, Michael Glei   +6 more
openalex   +1 more source

Macrophage PKM2 depletion ameliorates hepatic inflammation and acute liver injury in mice

Frontiers in Pharmacology
Introduction:Pyruvate kinase M2 (PKM2), the rate-limiting enzyme of glycolysis, plays a critical role in macrophage activation and a broad spectrum of chronic liver diseases.
Ziwei Kang, Ziwei Kang, Ruoyan Xie, Yiming Cui, Zhiwei Chen, Jincheng Li, Jinyu Lv, Weijia Ye, Peixin Zhao, Keke Zhang, Keke Zhang, Jian Hong, Jian Hong, Hengdong Qu, Hengdong Qu   +14 more
doaj   +1 more source

MLN4924: additional activities beyond neddylation inhibition

Molecular & Cellular Oncology, 2019
MLN4924, a small molecular inhibitor of NEDD8 (neuronal precursor cell-expressed developmentally downregulated protein 8) activating enzyme (NAE), blocks cullin neddylation to inactivate cullin-RING ligase. We found that MLN4924 has additional activities:
Qiyin Zhou, Yi Sun
doaj   +1 more source

Emerging roles of PKM2 in cell metabolism and cancer progression [PDF]

, 2012
Weibo Luo, Gregg L. Semenza
openalex   +1 more source

Erratum: ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect [PDF]

, 2012
Weiwei Yang, Yanhua Zheng, Yan Xia, Haitao Ji, Xiaohong Chen, Fang Guo, Costas A. Lyssiotis, Kenneth Aldape, Lewis C. Cantley, Zhimin Lu   +9 more
openalex   +1 more source

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells [PDF]

, 2013
William J. Israelsen, Talya L. Dayton, Shawn M. Davidson, Brian P. Fiske, Aaron M. Hosios, Gary Bellinger, Jie Li, Yimin Yu, Mika Sasaki, James W. Horner, Laura N. Burga, Jianxin Xie, Michael J. Jurczak, Ronald A. DePinho, Clary B. Clish, Tyler Jacks, Richard G. Kibbey, Gerburg M. Wulf, Dolores Di Vizio, Gordon B. Mills, Lewis C. Cantley, Matthew G. Vander Heiden   +21 more
openalex   +1 more source

Nuclear Pyruvate Kinase M2 Functional Study in Cancer Cells [PDF]

, 2010
Cancer cells take more glucose to provide energy and phosphoryl intermediates for cancer progression. Meanwhile, energy-provider function of mitochondria in cancer cells is disrupted.
Gao, Xueliang
core   +1 more source

Xue-fu-Zhu-Yu decoction protects rats against retinal ischemia by downregulation of HIF-1α and VEGF via inhibition of RBP2 and PKM2 [PDF]

, 2017
Shu-Qiu Tan, Xue Geng, Jorn‐Hon Liu, Wynn Hwai-Tzong Pan, Lixiang Wang, Hui‐Kang Liu, Lei Hu, Hsiao‐Ming Chao   +7 more
openalex   +1 more source