Results 131 to 140 of about 60,739 (253)

Acid‐Catalyzed Synthesis of Si‐Stereogenic Silanes

Chinese Journal of Chemistry, Volume 44, Issue 8, Page 1212-1222, 15 April 2026.
Si‐stereogenic silanes are important structural motifs in chemical synthesis, medicinal chemistry, and materials science. However, their catalytic enantioselective synthesis has largely relied on transition‐metal catalysts. Recently, Brønsted acids have been developed as promising alternatives.
Jung Tae Han, Benjamin List
wiley   +1 more source

PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes

Redox Biology, 2017
Osteoarthritis (OA) is a degenerative joint disease affecting a large population of people. Although the elevated expression of PKR (double stranded RNA-dependent protein kinase) and MMP-13 (collagenase-3) have been indicated to play pivotal roles in the
Ching-Hou Ma, Chin-Hsien Wu, I. Jou, Y. Tu, C. Hung, Pei-Ling Hsieh, Kun-Ling Tsai   +6 more
semanticscholar   +1 more source

Recent advances in agroforestry: supporting the transition from conventional to climate-resilient farming [PDF]

, 2018
N/
Nair, P.K.R.
core  

On a two variable class of Bernstein-Szego measures

, 2008
The one variable Bernstein-Szego theory for orthogonal polynomials on the real line is extended to a class of two variable measures. The polynomials orthonormal in the total degree ordering and the lexicographical ordering are constructed and their ...
A. Delgado, Antonia M. Delgado, C.F. Dunkl, D. Damanik, D. Jackson, G. Szegő, J. Geronimo, J.F. Diejen van, Jeffrey S. Geronimo, P.K. Suetin, Plamen Iliev, Yu.M. Berezanskii, Yuan Xu, Z. Grinshpun   +13 more
core   +1 more source

Delivering Effective Hepatitis C Virus Treatment in an Embedded Primary Care Setting Within a Tertiary Care Hospital in Karachi, Pakistan

Journal of Viral Hepatitis, Volume 33, Issue 4, April 2026.
ABSTRACT Hepatitis C virus (HCV) endemic regions require accessible treatment interventions. Effectiveness and costs of a pilot HCV treatment programme were evaluated at an embedded primary care service within a tertiary care centre at Indus Hospital and Health Network in Karachi, Pakistan.
Sabeen Shah, Nyashadzaishe Mafirakureva, Adam Trickey, Aliya Hasnain, Uzma Khan, Saira Khowaja, Hiba Ashraf, Naila Baig‐Ansari, Matthew Hickman, Peter Vickerman, Josephine G. Walker, Aaron G. Lim   +11 more
wiley   +1 more source

PKR associates with 4.1R to promote anchorage-independent growth of hepatocellular carcinoma and lead to poor prognosis

Scientific Reports
RNA-dependent protein kinase (PKR) may have a positive regulatory role in controlling tumor growth and progression in hepatocellular carcinoma (HCC). However, the downstream substrates and the molecular mechanism of PKR in the growth and progression of ...
Yusuke Okujima, Takao Watanabe, Takeshi Ito, Yasumichi Inoue, Yutaka Kasai, Yusuke Imai, Yoshiko Nakamura, Mitsuhito Koizumi, Osamu Yoshida, Yoshio Tokumoto, Masashi Hirooka, Masanori Abe, Ryosuke Kawakami, Takashi Saitou, Takeshi Imamura, Yoshinori Murakami, Yoichi Hiasa   +16 more
doaj   +1 more source

ORMDL Proteins Turnover via Proteasome and Autophagy Is Cell‐Type Dependent and Tied to Ceramide Homeostasis

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
ORMDL proteins in the endoplasmic reticulum (ER) negatively regulate serine palmitoyltransferase (SPT) activity in response to the rate of de novo sphingolipid synthesis. Disruption of ceramide homeostasis by myriocin or fumonisin B1 (FB1) appears to destabilize the ORMDL‐SPT complex, leading to ORMDL degradation as a feedback mechanism.
Michal Mrkacek, Magda Tumova, Alex Puskasu, Pavol Utekal, Marek Vrbacky, Ladislav Kuchar, Petr Draber, Viktor Bugajev   +7 more
wiley   +1 more source

Double-stranded RNA-dependent protein kinase regulates the motility of breast cancer cells.

PLoS ONE, 2012
Double-stranded RNA (dsRNA)-dependent protein kinase (PKR) is an interferon-induced protein kinase that plays a central role in the anti-viral process.
Mei Xu, Gang Chen, Siying Wang, Mingjun Liao, Jacqueline A Frank, Kimberly A Bower, Zhuo Zhang, Xianglin Shi, Jia Luo   +8 more
doaj   +1 more source

Direct Activation of Ribosome-Associated Double-Stranded RNA-Dependent Protein Kinase (PKR) by Deoxynivalenol, Anisomycin and Ricin: A New Model for Ribotoxic Stress Response Induction

Toxins, 2014
Double-stranded RNA (dsRNA)-activated protein kinase (PKR) is a critical upstream mediator of the ribotoxic stress response (RSR) to the trichothecene deoxynivalenol (DON) and other translational inhibitors.
Hui-Ren Zhou, Kaiyu He, Jeff Landgraf, Xiao Pan, James J. Pestka   +4 more
doaj   +1 more source

Foot-and-mouth disease virus induces lysosomal degradation of host protein kinase PKR by 3C proteinase to facilitate virus replication

Virology, 2017
The interferon-induced double-strand RNA activated protein kinase (PKR) plays important roles in host defense against viral infection. Here we demonstrate the significant antiviral role of PKR against foot-and-mouth disease virus (FMDV) and report that ...
Chuntian Li, Zixiang Zhu, Xiaoli Du, W. Cao, Fan Yang, Xiangle Zhang, Huanhuan Feng, Dan Li, Keshan Zhang, Xiang-tao Liu, Haixue Zheng   +10 more
semanticscholar   +1 more source