Results 91 to 100 of about 39,920 (262)

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia   +4 more
wiley   +1 more source

A computational screen for type I polyketide synthases in metagenomics shotgun data.

open access: yesPLoS ONE, 2008
BackgroundPolyketides are a diverse group of biotechnologically important secondary metabolites that are produced by multi domain enzymes called polyketide synthases (PKS).Methodology/principal findingsWe have estimated frequencies of type I PKS (PKS I) -
Konrad U Foerstner   +4 more
doaj   +1 more source

ExMODE: A comprehensive resource for extremophile genomic and functional exploration

open access: yesiMetaOmics, EarlyView.
ExMODE (https://db.genomics.cn/exmode/) integrates 3518 samples to build a unified extremophile resource, which hosts 1.35 billion habitat‐specific non‐redundant genes, 5.25 million representative protein structures, 67,026 metagenome‐assembled genomes (MAGs), and 164,132 biosynthetic gene clusters (BGCs). By combining sequence‐, structure‐, and genome‐
Denghui Li   +30 more
wiley   +1 more source

Propofol PK-PD

open access: yes, 2017
This is a comprehensive and authoritative presentation of total intravenous anesthesia (TIVA) and target controlled infusion (TCI). The editors’ international reputation has enabled them to recruit leading experts from around the world to write single-author chapters in their area of expertise.
openaire   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

open access: yesMed Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang   +9 more
wiley   +1 more source

Behavior of kernelrazzo floor finish in aggressive chloride environment

open access: yesCase Studies in Construction Materials, 2019
The rising cost of building materials in Nigeria has made it necessary to source for cheaper and locally available materials to be used in construction.
Olaniyi Arowojolu   +2 more
doaj   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai   +6 more
wiley   +1 more source

Perilaku PKS Lovers Di Media Sosial (Studi Netnografi Tindak Tutur PKS Lovers)

open access: yes, 2017
<p align="justify">The purpose of this study provides an overview of the behavior of PKS Lovers in social media post LHI arrested for alleged corruption in the bribery case of imported meat kuoata with PT Indoguna. The impact of these arrests makes
Dini Safitri
core   +1 more source

PERAN HUMAS FRAKSI PKS DPR RI DALAM MENSOSIALISASIKAN KINERJA ANGGOTA FRAKSI PKS JELANG PEMILU 2024

open access: yes, 2023
ABSTRAK (A)RAHMADI TRI YOGA/915200230 (B)PERAN HUMAS FRAKSI PKS DPR RI DALAM MENSOSIALISASIKAN KINERJA ANGGOTA FRAKSI PKS JELANG PEMILU 2024 (C)xvii + 58 hlm, Tahun 2023, tabel 4, gambar 4, Lampiran 3 (D)PUBLIC RELATIONS Abstrak: Dalam menjalankan
YOGA, RAHMADI TRI
core   +1 more source

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