Results 71 to 80 of about 212,073 (195)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Hybride Komposita in der kajkawischen Schriftsprache [PDF]
, 2011 U radu se analiziraju hibridne složenice – tvorenice sastavljene od germanizma i kajkavske riječi − u kajkavskome književnom jeziku. Istražuju se njihova čestotnost i struktura.
Štebih, Barbara
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Are there critical fatigue thresholds? Aggregated vs. individual data.
Frontiers in Physiology, 2016 The mechanisms underlying task failure from fatiguing physical efforts have been the focus of many studies without reaching consensus. An attractive but debated model explains effort termination with a critical peripheral fatigue threshold. Upon reaching
Daria Neyroud +2 more
doaj +1 more source
Zavajajoče dojemanje in gospodarska učinkovitost regionalnega sistema [PDF]
, 2012 Novost, ki jo prinaša ta članek, je uporaba učinka napačnega dojemanja na modelu središče-obrobje. Na podlagi teoretičnega modela bomo pokazali, da na prostem trgu ob uvedbi učinka napačnega dojemanja v model pride do napačne porazdelitve podjetij med ...
Miki Malul, Mosi Rosenboim, Tal Shavit
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Catering Industry Prices in Slovenia [PDF]
The empirical analysis investigates the causes of the catering industry inflation pre- and post-adoption of the Euro in Slovenia. The empirical analysis on the factors of inflation in the catering industry is based on the monthly statistical data during ...
Sergej Gricar, Stefan Bojnec
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source