Results 81 to 90 of about 937,159 (216)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Place attachment towards waterfront in Kangar, Perlis, Malaysia [PDF]
, 2016 This paper discusses place attachment to Kangar Waterfront in the state of Perlis, Malaysia. A questionnaire survey was conducted with users of the water front to identify the level of attachment, form of engagement and factors that influence the ...
Abdul Aziz, Faziawati +2 more
core
Olympic Experiences: The Significance of Place [PDF]
, 2017 Many studies analyse how events affect places, but few examine how places affect events. Existing research suggests that the physical qualities of a venue affect event experiences, but these studies often ignore more subtle dimensions of place such as ...
Assaker, G. +5 more
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Frontiers of Architectural Research, 2018 This research investigated the place attachment of a heritage place, namely, the Roman amphitheater, by using a valid model, the Kyle, Graefe, and Manning (2005) model.
Jawdat S. Goussous, Nessma A. Al-Hammadi
doaj +1 more source
Place attachment to contemporary public-funded mosques in Malaysia [PDF]
, 2012 Place is a Physical location formed by people’s relationship with physical environments, activities, and meanings. In this essence, Place Attachment is a concept that could describe the quality of the people’s relationship with a place.
Mohd Shariff, Mustafa Kamal +1 more
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Detached from their homeland: the Latter-day Saints of Chihuahua, Mexico [PDF]
, 2004 Over the past few decades, the homeland concept has received an ever-increasing amount of attention by cultural geographers. While the debate surrounding the necessity and applicability of the concept continues, it is more than apparent that no other ...
Smith, Jeffrey S., White, Benjamin N.
core +2 more sources
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source