Results 121 to 130 of about 17,689,950 (324)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A Hippocampal Model for Behavioral Time Acquisition and Fast Bidirectional Replay of Spatio-Temporal Memory Sequences

Frontiers in Neuroscience, 2018
The hippocampus is known to play a crucial role in the formation of long-term memory. For this, fast replays of previously experienced activities during sleep or after reward experiences are believed to be crucial.
Marcelo Matheus Gauy, Johannes Lengler, Hafsteinn Einarsson, Florian Meier, Felix Weissenberger, Mehmet Fatih Yanik, Angelika Steger   +6 more
doaj   +1 more source

Towards a neural-level cognitive architecture: modeling behavior in working memory tasks with neurons [PDF]

, 2019
Constrained by results from classic behavioral experiments we provide a neural-level cognitive architecture for modeling behavior in working memory tasks.
Cruzado, Nathaniel, Howard, Marc, Tiganj, Zoran   +2 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Trajectory events across hippocampal place-cells require previous experience

Nature Neuroscience, 2015
Replay of hippocampal place cell sequences has been proposed as a fundamental mechanism of learning and memory. However, the standard interpretation of replay has been challenged by reports that similar activity is observed before experience ('preplay').
Delia Silva, Ting Feng, David J. Foster
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Hippocampal Spike-Timing Correlations Lead to Hexagonal Grid Fields

, 2017
Space is represented in the mammalian brain by the activity of hippocampal place cells as well as in their spike-timing correlations. Here we propose a theory how this temporal code is transformed to spatial firing rate patterns via spike-timing ...
Leibold, Christian, Monsalve-Mercado, Mauro M.   +1 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Analysis of Effectivness of Magnetically Labeled Biosorbent Obtained Through the Mechanical and Magnetohydrodynamic Stirring [PDF]

, 2016
The efficiency of Cu2+ ion extraction of magnetically labeled biosorbent based on yeast Sacharomyces cerevisiae obtained by magnetohydrodynamic stirring in combined magnetic and electric fields has been determined.
Chyzh, Y. (Yulia), Golub, V. (Volodymyr), Gorobets, O. (Oksana), Gorobets, S. (Svitlana), Kovalev, O. (Oleksiy), Perizhok, V. (Valeriya)   +5 more
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source