Results 201 to 210 of about 16,525,519 (328)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Brain region-specific gain modulation of place cells by VIP neurons. [PDF]

Nat Commun
Lenkey N, Garvert AC, Neubrandt M, Kriener B, Vervaeke K.   +4 more
europepmc   +2 more sources

Hippocampal place cells map terrain geometry independently of behavior. [PDF]

Sci Adv
Grieves RM, Duvelle É, Taube JS.
europepmc   +1 more source

Tetrode recording of rat CA1 place cells in an observational spatial working memory task. [PDF]

STAR Protoc, 2022
Mou X, Suresh P, Ji D.
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Characterization of hippocampal dentate gyrus place cells.

, 2013
The hippocampus plays an essential role in learning and memory. The discovery of place cells in the hippocampus by O’Keefe in 1971 demonstrated that the hippocampus plays a crucial role in spatial navigation.
Chua, Samantha Xinyu.
core  

Place cells in CA1 lack topographical organization of firing locations. [PDF]

Proc Natl Acad Sci U S A
Slettmoen T, de Jong NL, Eneqvist H, Skytøen ER, Zong W, Moser MB, Moser EI.   +6 more
europepmc   +1 more source

Place cells dynamically refine grid cell activities to reduce error accumulation during path integration in a continuous attractor model. [PDF]

Sci Rep, 2022
Fernandez-Leon JA, Uysal AK, Ji D.
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Beyond place cells: Specific and cooperative roles of hippocampal interneuron families in spatial coding. [PDF]

Fundam Res
Cao JW, Jiang C.
europepmc   +1 more source